| Full name: aph-1 homolog B, gamma-secretase subunit | Alias Symbol: PSFL|APH-1B|DKFZp564D0372 | ||
| Type: protein-coding gene | Cytoband: 15q22.2 | ||
| Entrez ID: 83464 | HGNC ID: HGNC:24080 | Ensembl Gene: ENSG00000138613 | OMIM ID: 607630 |
| Drug and gene relationship at DGIdb | |||
APH1B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04330 | Notch signaling pathway |
Expression of APH1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APH1B | 83464 | 221036_s_at | 0.2314 | 0.6206 | |
| GSE20347 | APH1B | 83464 | 221036_s_at | 0.4782 | 0.0000 | |
| GSE23400 | APH1B | 83464 | 221036_s_at | 0.1704 | 0.0000 | |
| GSE26886 | APH1B | 83464 | 221036_s_at | 0.9427 | 0.0000 | |
| GSE29001 | APH1B | 83464 | 221036_s_at | 0.3497 | 0.0657 | |
| GSE38129 | APH1B | 83464 | 221036_s_at | 0.2988 | 0.0095 | |
| GSE45670 | APH1B | 83464 | 226358_at | -0.7545 | 0.0014 | |
| GSE53622 | APH1B | 83464 | 91982 | 0.6576 | 0.0000 | |
| GSE53624 | APH1B | 83464 | 91982 | 1.1770 | 0.0000 | |
| GSE63941 | APH1B | 83464 | 221036_s_at | -1.1177 | 0.0872 | |
| GSE77861 | APH1B | 83464 | 221036_s_at | 0.1262 | 0.3354 | |
| GSE97050 | APH1B | 83464 | A_23_P205997 | 0.1549 | 0.4774 | |
| SRP007169 | APH1B | 83464 | RNAseq | 0.9758 | 0.1959 | |
| SRP064894 | APH1B | 83464 | RNAseq | 0.1136 | 0.6731 | |
| SRP133303 | APH1B | 83464 | RNAseq | -0.2715 | 0.1412 | |
| SRP159526 | APH1B | 83464 | RNAseq | -0.4012 | 0.2210 | |
| SRP193095 | APH1B | 83464 | RNAseq | 0.5562 | 0.0008 | |
| SRP219564 | APH1B | 83464 | RNAseq | 0.5543 | 0.0894 | |
| TCGA | APH1B | 83464 | RNAseq | -0.2043 | 0.0123 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by APH1B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APH1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APH1B | 83464 | 8 | 2 | 20 | |
| GSE20123 | APH1B | 83464 | 8 | 2 | 20 | |
| GSE43470 | APH1B | 83464 | 4 | 6 | 33 | |
| GSE46452 | APH1B | 83464 | 3 | 7 | 49 | |
| GSE47630 | APH1B | 83464 | 8 | 10 | 22 | |
| GSE54993 | APH1B | 83464 | 5 | 6 | 59 | |
| GSE54994 | APH1B | 83464 | 6 | 8 | 39 | |
| GSE60625 | APH1B | 83464 | 4 | 0 | 7 | |
| GSE74703 | APH1B | 83464 | 4 | 3 | 29 | |
| GSE74704 | APH1B | 83464 | 4 | 2 | 14 | |
| TCGA | APH1B | 83464 | 10 | 17 | 69 |
Total number of gains: 64; Total number of losses: 63; Total Number of normals: 361.
Somatic mutations of APH1B:
Generating mutation plots.
Highly correlated genes for APH1B:
Showing top 20/1154 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APH1B | WDR54 | 0.795317 | 6 | 0 | 6 |
| APH1B | NEIL2 | 0.765699 | 3 | 0 | 3 |
| APH1B | RPL26L1 | 0.741945 | 3 | 0 | 3 |
| APH1B | FCGR3A | 0.740085 | 3 | 0 | 3 |
| APH1B | SSBP4 | 0.739222 | 3 | 0 | 3 |
| APH1B | CEP120 | 0.738829 | 4 | 0 | 4 |
| APH1B | LRRCC1 | 0.736665 | 4 | 0 | 4 |
| APH1B | RAB34 | 0.725804 | 3 | 0 | 3 |
| APH1B | LRRC8C | 0.724111 | 3 | 0 | 3 |
| APH1B | PSMA5 | 0.72371 | 3 | 0 | 3 |
| APH1B | PKIG | 0.721816 | 3 | 0 | 3 |
| APH1B | CERCAM | 0.720231 | 3 | 0 | 3 |
| APH1B | AGAP1 | 0.719754 | 3 | 0 | 3 |
| APH1B | AGBL5 | 0.719413 | 3 | 0 | 3 |
| APH1B | IGFBP5 | 0.719213 | 3 | 0 | 3 |
| APH1B | SND1 | 0.718076 | 3 | 0 | 3 |
| APH1B | SLC35B2 | 0.715255 | 3 | 0 | 3 |
| APH1B | NEDD8 | 0.713903 | 3 | 0 | 3 |
| APH1B | RCSD1 | 0.713133 | 3 | 0 | 3 |
| APH1B | LIN9 | 0.7106 | 3 | 0 | 3 |
For details and further investigation, click here
