PDE8A

 

Full name: phosphodiesterase 8A Alias Symbol: HsT19550
Type: protein-coding gene Cytoband: 15q25.3
Entrez ID: 5151 HGNC ID: HGNC:8793 Ensembl Gene: ENSG00000073417 OMIM ID: 602972
Drug and gene relationship at DGIdb

 

Expression of PDE8A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PDE8A 5151 212522_at 0.4865 0.1889
GSE20347 PDE8A 5151 212522_at 0.0523 0.8438
GSE23400 PDE8A 5151 212521_s_at 0.0362 0.4236
GSE26886 PDE8A 5151 212521_s_at 0.0267 0.8627
GSE29001 PDE8A 5151 212522_at 0.3323 0.3887
GSE38129 PDE8A 5151 212522_at -0.0456 0.8186
GSE45670 PDE8A 5151 212522_at 0.0359 0.8872
GSE53622 PDE8A 5151 51161 0.3430 0.0081
GSE53624 PDE8A 5151 51161 0.2995 0.0000
GSE63941 PDE8A 5151 212522_at -0.4836 0.2818
GSE77861 PDE8A 5151 212521_s_at 0.1674 0.4495
GSE97050 PDE8A 5151 A_33_P3244951 0.1165 0.6699
SRP007169 PDE8A 5151 RNAseq 0.0416 0.9244
SRP008496 PDE8A 5151 RNAseq 0.3966 0.1249
SRP064894 PDE8A 5151 RNAseq 0.4923 0.0212
SRP133303 PDE8A 5151 RNAseq 0.3444 0.0102
SRP159526 PDE8A 5151 RNAseq 0.2534 0.1856
SRP193095 PDE8A 5151 RNAseq 0.3140 0.0272
SRP219564 PDE8A 5151 RNAseq 0.7540 0.1462
TCGA PDE8A 5151 RNAseq -0.2645 0.0000

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by PDE8A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PDE8A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PDE8A 5151 8 0 22
GSE20123 PDE8A 5151 8 0 22
GSE43470 PDE8A 5151 4 4 35
GSE46452 PDE8A 5151 3 7 49
GSE47630 PDE8A 5151 8 10 22
GSE54993 PDE8A 5151 5 6 59
GSE54994 PDE8A 5151 6 6 41
GSE60625 PDE8A 5151 4 0 7
GSE74703 PDE8A 5151 4 2 30
GSE74704 PDE8A 5151 4 0 16
TCGA PDE8A 5151 17 13 66

Total number of gains: 71; Total number of losses: 48; Total Number of normals: 369.  

 

Somatic mutations of PDE8A:

 

Generating mutation plots.

 

Highly correlated genes for PDE8A:

 

Showing top 20/394 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PDE8AEGLN20.817382303
PDE8AERCC80.800195303
PDE8ANCBP10.782587303
PDE8ACOPS80.760963404
PDE8ASLC39A10.757984303
PDE8ALSM50.75732404
PDE8ATMEM600.756352303
PDE8AADORA2B0.755529303
PDE8AARPC50.752087303
PDE8ACNBP0.747348303
PDE8AORC40.746407303
PDE8ARABEPK0.744457303
PDE8AMIB10.740875303
PDE8AXPO40.738456303
PDE8AARSI0.738287303
PDE8ARPP140.736046303
PDE8AOSBPL60.734431303
PDE8AADAM170.734146303
PDE8ACBX10.720607303
PDE8AMRPS350.71838303

For details and further investigation, click here