| Full name: A-kinase anchoring protein 11 | Alias Symbol: KIAA0629|AKAP220|PRKA11|FLJ11304|DKFZp781I12161|PPP1R44 | ||
| Type: protein-coding gene | Cytoband: 13q14.11 | ||
| Entrez ID: 11215 | HGNC ID: HGNC:369 | Ensembl Gene: ENSG00000023516 | OMIM ID: 604696 |
| Drug and gene relationship at DGIdb | |||
Expression of AKAP11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AKAP11 | 11215 | 203156_at | -0.3200 | 0.4689 | |
| GSE20347 | AKAP11 | 11215 | 203156_at | -0.7560 | 0.0000 | |
| GSE23400 | AKAP11 | 11215 | 203156_at | -0.3054 | 0.0050 | |
| GSE26886 | AKAP11 | 11215 | 203156_at | -0.6156 | 0.0689 | |
| GSE29001 | AKAP11 | 11215 | 203156_at | -0.4422 | 0.1526 | |
| GSE38129 | AKAP11 | 11215 | 203156_at | -0.7388 | 0.0000 | |
| GSE45670 | AKAP11 | 11215 | 203156_at | -0.5789 | 0.0000 | |
| GSE53622 | AKAP11 | 11215 | 2136 | -0.3612 | 0.0000 | |
| GSE53624 | AKAP11 | 11215 | 2136 | -0.2937 | 0.0000 | |
| GSE63941 | AKAP11 | 11215 | 203156_at | -1.5069 | 0.0023 | |
| GSE77861 | AKAP11 | 11215 | 203156_at | -0.2980 | 0.4039 | |
| GSE97050 | AKAP11 | 11215 | A_33_P3409447 | -0.1809 | 0.5359 | |
| SRP007169 | AKAP11 | 11215 | RNAseq | -0.3552 | 0.3737 | |
| SRP008496 | AKAP11 | 11215 | RNAseq | 0.0332 | 0.8880 | |
| SRP064894 | AKAP11 | 11215 | RNAseq | -0.2846 | 0.2888 | |
| SRP133303 | AKAP11 | 11215 | RNAseq | -0.2607 | 0.0475 | |
| SRP159526 | AKAP11 | 11215 | RNAseq | -0.9396 | 0.0033 | |
| SRP193095 | AKAP11 | 11215 | RNAseq | -0.1302 | 0.1745 | |
| SRP219564 | AKAP11 | 11215 | RNAseq | -0.4612 | 0.0521 | |
| TCGA | AKAP11 | 11215 | RNAseq | -0.1284 | 0.0055 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by AKAP11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AKAP11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AKAP11 | 11215 | 0 | 13 | 17 | |
| GSE20123 | AKAP11 | 11215 | 0 | 12 | 18 | |
| GSE43470 | AKAP11 | 11215 | 3 | 13 | 27 | |
| GSE46452 | AKAP11 | 11215 | 0 | 33 | 26 | |
| GSE47630 | AKAP11 | 11215 | 2 | 27 | 11 | |
| GSE54993 | AKAP11 | 11215 | 12 | 2 | 56 | |
| GSE54994 | AKAP11 | 11215 | 1 | 16 | 36 | |
| GSE60625 | AKAP11 | 11215 | 0 | 3 | 8 | |
| GSE74703 | AKAP11 | 11215 | 3 | 10 | 23 | |
| GSE74704 | AKAP11 | 11215 | 0 | 9 | 11 | |
| TCGA | AKAP11 | 11215 | 8 | 40 | 48 |
Total number of gains: 29; Total number of losses: 178; Total Number of normals: 281.
Somatic mutations of AKAP11:
Generating mutation plots.
Highly correlated genes for AKAP11:
Showing top 20/1222 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AKAP11 | MTFR1L | 0.744347 | 5 | 0 | 5 |
| AKAP11 | TMOD1 | 0.740211 | 4 | 0 | 4 |
| AKAP11 | FRMD3 | 0.738046 | 4 | 0 | 4 |
| AKAP11 | C1QTNF7 | 0.73457 | 4 | 0 | 4 |
| AKAP11 | MGARP | 0.733993 | 3 | 0 | 3 |
| AKAP11 | ZNF44 | 0.732506 | 4 | 0 | 4 |
| AKAP11 | FNDC5 | 0.72838 | 3 | 0 | 3 |
| AKAP11 | SERINC1 | 0.724228 | 11 | 0 | 11 |
| AKAP11 | CAMTA1 | 0.719277 | 3 | 0 | 3 |
| AKAP11 | SNX4 | 0.715338 | 3 | 0 | 3 |
| AKAP11 | NUB1 | 0.708309 | 3 | 0 | 3 |
| AKAP11 | ERVW-1 | 0.705563 | 3 | 0 | 3 |
| AKAP11 | EZH1 | 0.70381 | 8 | 0 | 7 |
| AKAP11 | MAMDC2 | 0.700277 | 5 | 0 | 5 |
| AKAP11 | MTMR12 | 0.700096 | 3 | 0 | 3 |
| AKAP11 | NME5 | 0.697227 | 6 | 0 | 6 |
| AKAP11 | IFT81 | 0.695553 | 3 | 0 | 3 |
| AKAP11 | FBXL3 | 0.693579 | 7 | 0 | 6 |
| AKAP11 | TAF7 | 0.691771 | 5 | 0 | 4 |
| AKAP11 | A2M-AS1 | 0.690205 | 4 | 0 | 4 |
For details and further investigation, click here
