| Full name: enhancer of zeste 1 polycomb repressive complex 2 subunit | Alias Symbol: KIAA0388|KMT6B | ||
| Type: protein-coding gene | Cytoband: 17q21.2 | ||
| Entrez ID: 2145 | HGNC ID: HGNC:3526 | Ensembl Gene: ENSG00000108799 | OMIM ID: 601674 |
| Drug and gene relationship at DGIdb | |||
Expression of EZH1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EZH1 | 2145 | 32259_at | -0.8982 | 0.1004 | |
| GSE20347 | EZH1 | 2145 | 32259_at | -0.2919 | 0.0077 | |
| GSE23400 | EZH1 | 2145 | 203249_at | -0.3603 | 0.0000 | |
| GSE26886 | EZH1 | 2145 | 32259_at | -0.5205 | 0.0454 | |
| GSE29001 | EZH1 | 2145 | 32259_at | -0.3934 | 0.1638 | |
| GSE38129 | EZH1 | 2145 | 32259_at | -0.6479 | 0.0001 | |
| GSE45670 | EZH1 | 2145 | 32259_at | -0.6433 | 0.0000 | |
| GSE53622 | EZH1 | 2145 | 129861 | -0.6585 | 0.0000 | |
| GSE53624 | EZH1 | 2145 | 129861 | -0.6829 | 0.0000 | |
| GSE63941 | EZH1 | 2145 | 32259_at | -0.6497 | 0.0085 | |
| GSE77861 | EZH1 | 2145 | 203249_at | 0.0281 | 0.9098 | |
| GSE97050 | EZH1 | 2145 | A_23_P428219 | -0.9504 | 0.0684 | |
| SRP007169 | EZH1 | 2145 | RNAseq | -1.1270 | 0.0020 | |
| SRP008496 | EZH1 | 2145 | RNAseq | -1.2899 | 0.0000 | |
| SRP064894 | EZH1 | 2145 | RNAseq | -0.4417 | 0.0001 | |
| SRP133303 | EZH1 | 2145 | RNAseq | -0.7906 | 0.0000 | |
| SRP159526 | EZH1 | 2145 | RNAseq | -0.6109 | 0.0341 | |
| SRP193095 | EZH1 | 2145 | RNAseq | -0.4936 | 0.0000 | |
| SRP219564 | EZH1 | 2145 | RNAseq | -0.7349 | 0.0159 | |
| TCGA | EZH1 | 2145 | RNAseq | -0.2600 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by EZH1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EZH1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EZH1 | 2145 | 6 | 2 | 22 | |
| GSE20123 | EZH1 | 2145 | 6 | 2 | 22 | |
| GSE43470 | EZH1 | 2145 | 1 | 2 | 40 | |
| GSE46452 | EZH1 | 2145 | 34 | 0 | 25 | |
| GSE47630 | EZH1 | 2145 | 8 | 1 | 31 | |
| GSE54993 | EZH1 | 2145 | 3 | 4 | 63 | |
| GSE54994 | EZH1 | 2145 | 8 | 5 | 40 | |
| GSE60625 | EZH1 | 2145 | 4 | 0 | 7 | |
| GSE74703 | EZH1 | 2145 | 1 | 1 | 34 | |
| GSE74704 | EZH1 | 2145 | 4 | 1 | 15 | |
| TCGA | EZH1 | 2145 | 23 | 6 | 67 |
Total number of gains: 98; Total number of losses: 24; Total Number of normals: 366.
Somatic mutations of EZH1:
Generating mutation plots.
Highly correlated genes for EZH1:
Showing top 20/1160 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EZH1 | FNIP2 | 0.816185 | 3 | 0 | 3 |
| EZH1 | KIAA1143 | 0.79576 | 3 | 0 | 3 |
| EZH1 | GPIHBP1 | 0.777389 | 3 | 0 | 3 |
| EZH1 | FRMD3 | 0.775489 | 4 | 0 | 4 |
| EZH1 | ANAPC16 | 0.767664 | 4 | 0 | 4 |
| EZH1 | FNDC5 | 0.764625 | 3 | 0 | 3 |
| EZH1 | PDCD4 | 0.755852 | 3 | 0 | 3 |
| EZH1 | NLGN4Y | 0.755456 | 3 | 0 | 3 |
| EZH1 | C3orf70 | 0.747722 | 4 | 0 | 4 |
| EZH1 | RUNX1T1 | 0.742677 | 5 | 0 | 5 |
| EZH1 | ZMAT3 | 0.741678 | 3 | 0 | 3 |
| EZH1 | RNASE4 | 0.737505 | 5 | 0 | 5 |
| EZH1 | C1QTNF7 | 0.733784 | 5 | 0 | 4 |
| EZH1 | GNG7 | 0.728867 | 7 | 0 | 6 |
| EZH1 | ZNF436 | 0.727682 | 3 | 0 | 3 |
| EZH1 | PEG3 | 0.726622 | 6 | 0 | 6 |
| EZH1 | AFF3 | 0.726313 | 4 | 0 | 3 |
| EZH1 | CLIP3 | 0.725334 | 8 | 0 | 8 |
| EZH1 | GFRA1 | 0.724286 | 6 | 0 | 5 |
| EZH1 | XKR4 | 0.724263 | 5 | 0 | 4 |
For details and further investigation, click here
