AKT2

 

Full name: AKT serine/threonine kinase 2 Alias Symbol: PKBβ
Type: protein-coding gene Cytoband: 19q13.2
Entrez ID: 208 HGNC ID: HGNC:392 Ensembl Gene: ENSG00000105221 OMIM ID: 164731
Drug and gene relationship at DGIdb

 

AKT2 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04066HIF-1 signaling pathway
hsa04068FoxO signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04210Apoptosis
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04261Adrenergic signaling in cardiomyocytes
hsa04370VEGF signaling pathway
hsa04380Osteoclast differentiation
hsa04510Focal adhesion
hsa04530Tight junction
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04611Platelet activation
hsa04620Toll-like receptor signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04668TNF signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04725Cholinergic synapse
hsa04728Dopaminergic synapse
hsa04910Insulin signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04915Estrogen signaling pathway
hsa04917Prolactin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04922Glucagon signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04931Insulin resistance
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa04973Carbohydrate digestion and absorption
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05152Tuberculosis
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05162Measles
hsa05164Influenza A
hsa05166HTLV-I infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05210Colorectal cancer
hsa05211Renal cell carcinoma
hsa05212Pancreatic cancer
hsa05213Endometrial cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05222Small cell lung cancer
hsa05223Non-small cell lung cancer
hsa05231Choline metabolism in cancer

 

Expression of AKT2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 AKT2 208 225471_s_at 0.2523 0.6060
GSE20347 AKT2 208 211453_s_at 0.0861 0.3056
GSE23400 AKT2 208 211453_s_at -0.0409 0.3560
GSE26886 AKT2 208 225471_s_at -0.0605 0.7170
GSE29001 AKT2 208 211453_s_at -0.0156 0.8904
GSE38129 AKT2 208 211453_s_at -0.0420 0.6450
GSE45670 AKT2 208 225471_s_at 0.0562 0.6101
GSE53622 AKT2 208 14287 -0.1692 0.0004
GSE53624 AKT2 208 14287 0.0466 0.4170
GSE63941 AKT2 208 225471_s_at -0.0834 0.8485
GSE77861 AKT2 208 225471_s_at 0.1565 0.5759
GSE97050 AKT2 208 A_33_P3400171 -0.0856 0.7643
SRP007169 AKT2 208 RNAseq -1.0966 0.0007
SRP008496 AKT2 208 RNAseq -1.0972 0.0000
SRP064894 AKT2 208 RNAseq -0.0607 0.6804
SRP133303 AKT2 208 RNAseq -0.1261 0.4406
SRP159526 AKT2 208 RNAseq -0.1576 0.2689
SRP193095 AKT2 208 RNAseq -0.2135 0.0326
SRP219564 AKT2 208 RNAseq -0.3133 0.1155
TCGA AKT2 208 RNAseq 0.0061 0.8897

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by AKT2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of AKT2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 AKT2 208 6 5 19
GSE20123 AKT2 208 6 4 20
GSE43470 AKT2 208 3 9 31
GSE46452 AKT2 208 48 1 10
GSE47630 AKT2 208 9 5 26
GSE54993 AKT2 208 17 3 50
GSE54994 AKT2 208 8 9 36
GSE60625 AKT2 208 9 0 2
GSE74703 AKT2 208 3 6 27
GSE74704 AKT2 208 6 2 12
TCGA AKT2 208 14 16 66

Total number of gains: 129; Total number of losses: 60; Total Number of normals: 299.  

 

Somatic mutations of AKT2:

 

Generating mutation plots.

 

Highly correlated genes for AKT2:

 

Showing top 20/287 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
AKT2PIAS30.837921303
AKT2POLR2A0.803895303
AKT2MIA30.785717303
AKT2PHF230.776613303
AKT2TIMM8A0.776316303
AKT2AARS20.772132303
AKT2SSBP40.76748303
AKT2MED290.753969303
AKT2ZNF2600.746661303
AKT2SURF60.744926303
AKT2DPP90.738551303
AKT2HNRNPUL10.735903404
AKT2UBAP2L0.735654303
AKT2CHD30.730174303
AKT2STAT20.723635404
AKT2ZNF1240.719572303
AKT2ELAC20.718611303
AKT2USP340.715432303
AKT2TRAPPC10.711317303
AKT2SMARCD20.709675303

For details and further investigation, click here