| Full name: alanyl-tRNA synthetase 2, mitochondrial | Alias Symbol: KIAA1270|bA444E17.1 | ||
| Type: protein-coding gene | Cytoband: 6p21.1 | ||
| Entrez ID: 57505 | HGNC ID: HGNC:21022 | Ensembl Gene: ENSG00000124608 | OMIM ID: 612035 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of AARS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AARS2 | 57505 | 231845_at | 0.1982 | 0.8099 | |
| GSE26886 | AARS2 | 57505 | 231845_at | 0.0702 | 0.7660 | |
| GSE45670 | AARS2 | 57505 | 231845_at | 0.0493 | 0.7589 | |
| GSE53622 | AARS2 | 57505 | 49989 | -0.2939 | 0.0003 | |
| GSE53624 | AARS2 | 57505 | 49989 | -0.1331 | 0.0212 | |
| GSE63941 | AARS2 | 57505 | 231845_at | 0.2759 | 0.2429 | |
| GSE77861 | AARS2 | 57505 | 230024_at | -0.0773 | 0.4843 | |
| GSE97050 | AARS2 | 57505 | A_23_P383688 | 0.0532 | 0.8717 | |
| SRP007169 | AARS2 | 57505 | RNAseq | -0.5941 | 0.1172 | |
| SRP008496 | AARS2 | 57505 | RNAseq | -0.4741 | 0.0625 | |
| SRP064894 | AARS2 | 57505 | RNAseq | 0.0253 | 0.8729 | |
| SRP133303 | AARS2 | 57505 | RNAseq | -0.2831 | 0.0367 | |
| SRP159526 | AARS2 | 57505 | RNAseq | 0.1944 | 0.6329 | |
| SRP193095 | AARS2 | 57505 | RNAseq | -0.1093 | 0.3500 | |
| SRP219564 | AARS2 | 57505 | RNAseq | 0.2645 | 0.4130 | |
| TCGA | AARS2 | 57505 | RNAseq | 0.0091 | 0.8851 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by AARS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AARS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AARS2 | 57505 | 7 | 1 | 22 | |
| GSE20123 | AARS2 | 57505 | 7 | 1 | 22 | |
| GSE43470 | AARS2 | 57505 | 6 | 0 | 37 | |
| GSE46452 | AARS2 | 57505 | 3 | 9 | 47 | |
| GSE47630 | AARS2 | 57505 | 8 | 4 | 28 | |
| GSE54993 | AARS2 | 57505 | 3 | 2 | 65 | |
| GSE54994 | AARS2 | 57505 | 8 | 3 | 42 | |
| GSE60625 | AARS2 | 57505 | 0 | 3 | 8 | |
| GSE74703 | AARS2 | 57505 | 6 | 0 | 30 | |
| GSE74704 | AARS2 | 57505 | 3 | 1 | 16 | |
| TCGA | AARS2 | 57505 | 21 | 14 | 61 |
Total number of gains: 72; Total number of losses: 38; Total Number of normals: 378.
Somatic mutations of AARS2:
Generating mutation plots.
Highly correlated genes for AARS2:
Showing top 20/138 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AARS2 | AKT2 | 0.772132 | 3 | 0 | 3 |
| AARS2 | AVP | 0.771818 | 3 | 0 | 3 |
| AARS2 | SUGP1 | 0.765944 | 3 | 0 | 3 |
| AARS2 | RFX1 | 0.763463 | 3 | 0 | 3 |
| AARS2 | POU2F1 | 0.763029 | 3 | 0 | 3 |
| AARS2 | SYMPK | 0.750606 | 3 | 0 | 3 |
| AARS2 | RBM8A | 0.735965 | 3 | 0 | 3 |
| AARS2 | MIER2 | 0.731332 | 3 | 0 | 3 |
| AARS2 | NR2F6 | 0.730385 | 3 | 0 | 3 |
| AARS2 | ZMIZ2 | 0.723176 | 3 | 0 | 3 |
| AARS2 | LAMP1 | 0.710657 | 3 | 0 | 3 |
| AARS2 | NEK8 | 0.702027 | 3 | 0 | 3 |
| AARS2 | HSD17B10 | 0.694947 | 3 | 0 | 3 |
| AARS2 | HECTD3 | 0.68992 | 3 | 0 | 3 |
| AARS2 | CCDC12 | 0.68793 | 3 | 0 | 3 |
| AARS2 | APH1A | 0.686592 | 3 | 0 | 3 |
| AARS2 | DENND4B | 0.678088 | 3 | 0 | 3 |
| AARS2 | NDUFA2 | 0.676881 | 3 | 0 | 3 |
| AARS2 | OXNAD1 | 0.676053 | 3 | 0 | 3 |
| AARS2 | OGG1 | 0.674536 | 3 | 0 | 3 |
For details and further investigation, click here
