| Full name: 5'-aminolevulinate synthase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3p21.2 | ||
| Entrez ID: 211 | HGNC ID: HGNC:396 | Ensembl Gene: ENSG00000023330 | OMIM ID: 125290 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ALAS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALAS1 | 211 | 205633_s_at | -0.2954 | 0.7281 | |
| GSE20347 | ALAS1 | 211 | 205633_s_at | -0.5440 | 0.0027 | |
| GSE23400 | ALAS1 | 211 | 205633_s_at | -0.3623 | 0.0000 | |
| GSE26886 | ALAS1 | 211 | 205633_s_at | -1.3910 | 0.0000 | |
| GSE29001 | ALAS1 | 211 | 205633_s_at | -0.7546 | 0.0612 | |
| GSE38129 | ALAS1 | 211 | 205633_s_at | -0.4569 | 0.0020 | |
| GSE45670 | ALAS1 | 211 | 205633_s_at | 0.0311 | 0.8937 | |
| GSE53622 | ALAS1 | 211 | 83462 | -0.3061 | 0.0002 | |
| GSE53624 | ALAS1 | 211 | 83462 | -0.4318 | 0.0000 | |
| GSE63941 | ALAS1 | 211 | 205633_s_at | 0.2070 | 0.5664 | |
| GSE77861 | ALAS1 | 211 | 205633_s_at | -0.1896 | 0.6002 | |
| GSE97050 | ALAS1 | 211 | A_24_P191588 | 0.1110 | 0.6478 | |
| SRP007169 | ALAS1 | 211 | RNAseq | 0.0559 | 0.9193 | |
| SRP008496 | ALAS1 | 211 | RNAseq | 0.1415 | 0.7247 | |
| SRP064894 | ALAS1 | 211 | RNAseq | -0.3422 | 0.0132 | |
| SRP133303 | ALAS1 | 211 | RNAseq | -0.2000 | 0.1832 | |
| SRP159526 | ALAS1 | 211 | RNAseq | -0.1073 | 0.7303 | |
| SRP193095 | ALAS1 | 211 | RNAseq | -0.6315 | 0.0000 | |
| SRP219564 | ALAS1 | 211 | RNAseq | -0.7651 | 0.0006 | |
| TCGA | ALAS1 | 211 | RNAseq | -0.2201 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by ALAS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALAS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALAS1 | 211 | 0 | 18 | 12 | |
| GSE20123 | ALAS1 | 211 | 0 | 19 | 11 | |
| GSE43470 | ALAS1 | 211 | 0 | 18 | 25 | |
| GSE46452 | ALAS1 | 211 | 2 | 17 | 40 | |
| GSE47630 | ALAS1 | 211 | 1 | 24 | 15 | |
| GSE54993 | ALAS1 | 211 | 6 | 2 | 62 | |
| GSE54994 | ALAS1 | 211 | 0 | 34 | 19 | |
| GSE60625 | ALAS1 | 211 | 5 | 0 | 6 | |
| GSE74703 | ALAS1 | 211 | 0 | 14 | 22 | |
| GSE74704 | ALAS1 | 211 | 0 | 12 | 8 | |
| TCGA | ALAS1 | 211 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 236; Total Number of normals: 238.
Somatic mutations of ALAS1:
Generating mutation plots.
Highly correlated genes for ALAS1:
Showing top 20/1077 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALAS1 | SNX17 | 0.807399 | 4 | 0 | 4 |
| ALAS1 | HDHD2 | 0.805276 | 3 | 0 | 3 |
| ALAS1 | ESYT2 | 0.798841 | 3 | 0 | 3 |
| ALAS1 | ZFC3H1 | 0.77839 | 3 | 0 | 3 |
| ALAS1 | TMEM17 | 0.778069 | 3 | 0 | 3 |
| ALAS1 | ACER3 | 0.759659 | 3 | 0 | 3 |
| ALAS1 | GLYR1 | 0.75827 | 3 | 0 | 3 |
| ALAS1 | TMEM50A | 0.754374 | 3 | 0 | 3 |
| ALAS1 | CTTNBP2NL | 0.748451 | 5 | 0 | 5 |
| ALAS1 | CNOT10 | 0.744579 | 3 | 0 | 3 |
| ALAS1 | ZNF304 | 0.742977 | 3 | 0 | 3 |
| ALAS1 | CCNYL1 | 0.741636 | 4 | 0 | 3 |
| ALAS1 | PKN2 | 0.73535 | 5 | 0 | 5 |
| ALAS1 | KCTD21 | 0.731242 | 3 | 0 | 3 |
| ALAS1 | ACTR2 | 0.72839 | 4 | 0 | 3 |
| ALAS1 | ALKBH7 | 0.727241 | 3 | 0 | 3 |
| ALAS1 | GPR108 | 0.724716 | 3 | 0 | 3 |
| ALAS1 | FOPNL | 0.722506 | 4 | 0 | 3 |
| ALAS1 | CDC123 | 0.720449 | 4 | 0 | 4 |
| ALAS1 | GMPPB | 0.719321 | 3 | 0 | 3 |
For details and further investigation, click here
