| Full name: alkaline ceramidase 3 | Alias Symbol: FLJ11238|APHC | ||
| Type: protein-coding gene | Cytoband: 11q13.5 | ||
| Entrez ID: 55331 | HGNC ID: HGNC:16066 | Ensembl Gene: ENSG00000078124 | OMIM ID: 617036 |
| Drug and gene relationship at DGIdb | |||
Expression of ACER3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACER3 | 55331 | 227776_at | -0.1177 | 0.9262 | |
| GSE26886 | ACER3 | 55331 | 227776_at | -0.6369 | 0.0391 | |
| GSE45670 | ACER3 | 55331 | 227776_at | -0.1497 | 0.5539 | |
| GSE53622 | ACER3 | 55331 | 130758 | 0.1734 | 0.1399 | |
| GSE53624 | ACER3 | 55331 | 130758 | -0.3774 | 0.0002 | |
| GSE63941 | ACER3 | 55331 | 227776_at | 0.3931 | 0.6852 | |
| GSE77861 | ACER3 | 55331 | 222688_at | -0.1434 | 0.7874 | |
| GSE97050 | ACER3 | 55331 | A_23_P203665 | 0.4870 | 0.2937 | |
| SRP007169 | ACER3 | 55331 | RNAseq | -0.3734 | 0.3100 | |
| SRP008496 | ACER3 | 55331 | RNAseq | -0.2264 | 0.4782 | |
| SRP064894 | ACER3 | 55331 | RNAseq | -0.3276 | 0.0554 | |
| SRP133303 | ACER3 | 55331 | RNAseq | -0.1552 | 0.2952 | |
| SRP159526 | ACER3 | 55331 | RNAseq | -0.7700 | 0.0000 | |
| SRP193095 | ACER3 | 55331 | RNAseq | -0.4401 | 0.0064 | |
| SRP219564 | ACER3 | 55331 | RNAseq | -0.0850 | 0.8891 | |
| TCGA | ACER3 | 55331 | RNAseq | 0.0750 | 0.2787 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ACER3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACER3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACER3 | 55331 | 6 | 9 | 15 | |
| GSE20123 | ACER3 | 55331 | 6 | 8 | 16 | |
| GSE43470 | ACER3 | 55331 | 3 | 3 | 37 | |
| GSE46452 | ACER3 | 55331 | 7 | 22 | 30 | |
| GSE47630 | ACER3 | 55331 | 5 | 16 | 19 | |
| GSE54993 | ACER3 | 55331 | 8 | 2 | 60 | |
| GSE54994 | ACER3 | 55331 | 7 | 17 | 29 | |
| GSE60625 | ACER3 | 55331 | 4 | 3 | 4 | |
| GSE74703 | ACER3 | 55331 | 2 | 2 | 32 | |
| GSE74704 | ACER3 | 55331 | 4 | 4 | 12 | |
| TCGA | ACER3 | 55331 | 20 | 31 | 45 |
Total number of gains: 72; Total number of losses: 117; Total Number of normals: 299.
Somatic mutations of ACER3:
Generating mutation plots.
Highly correlated genes for ACER3:
Showing top 20/169 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACER3 | PLA2G4A | 0.817433 | 3 | 0 | 3 |
| ACER3 | ALAS1 | 0.759659 | 3 | 0 | 3 |
| ACER3 | PMM2 | 0.752267 | 3 | 0 | 3 |
| ACER3 | NOD1 | 0.749744 | 3 | 0 | 3 |
| ACER3 | FOPNL | 0.744479 | 3 | 0 | 3 |
| ACER3 | DNASE1L1 | 0.742662 | 3 | 0 | 3 |
| ACER3 | SPECC1 | 0.741122 | 3 | 0 | 3 |
| ACER3 | WDR61 | 0.730375 | 3 | 0 | 3 |
| ACER3 | AQR | 0.726668 | 4 | 0 | 4 |
| ACER3 | BTBD1 | 0.721218 | 3 | 0 | 3 |
| ACER3 | GPD2 | 0.716365 | 3 | 0 | 3 |
| ACER3 | EIF2AK4 | 0.71218 | 3 | 0 | 3 |
| ACER3 | PCSK5 | 0.709766 | 4 | 0 | 4 |
| ACER3 | PGAP2 | 0.709695 | 3 | 0 | 3 |
| ACER3 | DLAT | 0.709467 | 3 | 0 | 3 |
| ACER3 | SMC6 | 0.703834 | 3 | 0 | 3 |
| ACER3 | TPMT | 0.702525 | 3 | 0 | 3 |
| ACER3 | MRPS31 | 0.70116 | 3 | 0 | 3 |
| ACER3 | SKA2 | 0.701153 | 3 | 0 | 3 |
| ACER3 | SPTLC3 | 0.700814 | 3 | 0 | 3 |
For details and further investigation, click here
