| Full name: CCR4-NOT transcription complex subunit 10 | Alias Symbol: FLJ12890|FLJ13165 | ||
| Type: protein-coding gene | Cytoband: 3p22.3 | ||
| Entrez ID: 25904 | HGNC ID: HGNC:23817 | Ensembl Gene: ENSG00000182973 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CNOT10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CNOT10 | 25904 | 223219_s_at | 0.1905 | 0.5908 | |
| GSE26886 | CNOT10 | 25904 | 223219_s_at | -0.6518 | 0.0026 | |
| GSE45670 | CNOT10 | 25904 | 223219_s_at | 0.0212 | 0.8798 | |
| GSE53622 | CNOT10 | 25904 | 41097 | -0.2200 | 0.0003 | |
| GSE53624 | CNOT10 | 25904 | 41097 | -0.0393 | 0.4356 | |
| GSE63941 | CNOT10 | 25904 | 223219_s_at | 1.1913 | 0.0028 | |
| GSE77861 | CNOT10 | 25904 | 223219_s_at | 0.0265 | 0.8618 | |
| GSE97050 | CNOT10 | 25904 | A_23_P112652 | -0.0060 | 0.9812 | |
| SRP007169 | CNOT10 | 25904 | RNAseq | -0.3316 | 0.3986 | |
| SRP008496 | CNOT10 | 25904 | RNAseq | -0.1242 | 0.6664 | |
| SRP064894 | CNOT10 | 25904 | RNAseq | 0.0971 | 0.3952 | |
| SRP133303 | CNOT10 | 25904 | RNAseq | -0.1617 | 0.2951 | |
| SRP159526 | CNOT10 | 25904 | RNAseq | -0.1975 | 0.4167 | |
| SRP193095 | CNOT10 | 25904 | RNAseq | -0.3309 | 0.0001 | |
| SRP219564 | CNOT10 | 25904 | RNAseq | -0.2432 | 0.3176 | |
| TCGA | CNOT10 | 25904 | RNAseq | 0.0228 | 0.6733 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CNOT10 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CNOT10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CNOT10 | 25904 | 0 | 18 | 12 | |
| GSE20123 | CNOT10 | 25904 | 0 | 18 | 12 | |
| GSE43470 | CNOT10 | 25904 | 1 | 19 | 23 | |
| GSE46452 | CNOT10 | 25904 | 2 | 17 | 40 | |
| GSE47630 | CNOT10 | 25904 | 1 | 25 | 14 | |
| GSE54993 | CNOT10 | 25904 | 6 | 3 | 61 | |
| GSE54994 | CNOT10 | 25904 | 1 | 32 | 20 | |
| GSE60625 | CNOT10 | 25904 | 5 | 0 | 6 | |
| GSE74703 | CNOT10 | 25904 | 1 | 16 | 19 | |
| GSE74704 | CNOT10 | 25904 | 0 | 12 | 8 | |
| TCGA | CNOT10 | 25904 | 2 | 69 | 25 |
Total number of gains: 19; Total number of losses: 229; Total Number of normals: 240.
Somatic mutations of CNOT10:
Generating mutation plots.
Highly correlated genes for CNOT10:
Showing top 20/470 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CNOT10 | RPP38 | 0.859027 | 3 | 0 | 3 |
| CNOT10 | CRK | 0.836822 | 3 | 0 | 3 |
| CNOT10 | CMTM4 | 0.813093 | 3 | 0 | 3 |
| CNOT10 | SMC3 | 0.808934 | 3 | 0 | 3 |
| CNOT10 | MRPL42 | 0.802709 | 3 | 0 | 3 |
| CNOT10 | HMGN1 | 0.798348 | 3 | 0 | 3 |
| CNOT10 | SYNE2 | 0.795944 | 3 | 0 | 3 |
| CNOT10 | GLO1 | 0.79569 | 3 | 0 | 3 |
| CNOT10 | GCDH | 0.794161 | 3 | 0 | 3 |
| CNOT10 | HIC2 | 0.78802 | 3 | 0 | 3 |
| CNOT10 | COMMD2 | 0.785018 | 3 | 0 | 3 |
| CNOT10 | CMTM6 | 0.777135 | 3 | 0 | 3 |
| CNOT10 | HCCS | 0.772733 | 3 | 0 | 3 |
| CNOT10 | PUS7L | 0.771373 | 3 | 0 | 3 |
| CNOT10 | ZBTB1 | 0.768745 | 3 | 0 | 3 |
| CNOT10 | ZNF436 | 0.768248 | 3 | 0 | 3 |
| CNOT10 | LARP4 | 0.764199 | 3 | 0 | 3 |
| CNOT10 | GLRX5 | 0.760475 | 3 | 0 | 3 |
| CNOT10 | FRAT1 | 0.759481 | 3 | 0 | 3 |
| CNOT10 | UNC5CL | 0.75716 | 3 | 0 | 3 |
For details and further investigation, click here
