| Full name: potassium channel tetramerization domain containing 21 | Alias Symbol: KCASH2 | ||
| Type: protein-coding gene | Cytoband: 11q14.1 | ||
| Entrez ID: 283219 | HGNC ID: HGNC:27452 | Ensembl Gene: ENSG00000188997 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of KCTD21:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KCTD21 | 283219 | 229873_at | -0.2833 | 0.7606 | |
| GSE26886 | KCTD21 | 283219 | 229873_at | -0.5884 | 0.0447 | |
| GSE45670 | KCTD21 | 283219 | 229873_at | -0.0750 | 0.7776 | |
| GSE53622 | KCTD21 | 283219 | 106136 | 0.2442 | 0.0002 | |
| GSE53624 | KCTD21 | 283219 | 106136 | 0.0593 | 0.3662 | |
| GSE63941 | KCTD21 | 283219 | 229873_at | -1.5353 | 0.0252 | |
| GSE77861 | KCTD21 | 283219 | 229873_at | -0.3510 | 0.2657 | |
| GSE97050 | KCTD21 | 283219 | A_33_P3299525 | -0.0827 | 0.7060 | |
| SRP007169 | KCTD21 | 283219 | RNAseq | -0.4326 | 0.3516 | |
| SRP064894 | KCTD21 | 283219 | RNAseq | -0.8185 | 0.0000 | |
| SRP133303 | KCTD21 | 283219 | RNAseq | -0.7164 | 0.0000 | |
| SRP159526 | KCTD21 | 283219 | RNAseq | -1.1410 | 0.0115 | |
| SRP193095 | KCTD21 | 283219 | RNAseq | -0.8522 | 0.0000 | |
| SRP219564 | KCTD21 | 283219 | RNAseq | -0.2031 | 0.6389 | |
| TCGA | KCTD21 | 283219 | RNAseq | -0.0279 | 0.7534 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by KCTD21 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KCTD21:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KCTD21 | 283219 | 3 | 10 | 17 | |
| GSE20123 | KCTD21 | 283219 | 3 | 9 | 18 | |
| GSE43470 | KCTD21 | 283219 | 3 | 5 | 35 | |
| GSE46452 | KCTD21 | 283219 | 7 | 22 | 30 | |
| GSE47630 | KCTD21 | 283219 | 4 | 17 | 19 | |
| GSE54993 | KCTD21 | 283219 | 8 | 2 | 60 | |
| GSE54994 | KCTD21 | 283219 | 5 | 17 | 31 | |
| GSE60625 | KCTD21 | 283219 | 4 | 3 | 4 | |
| GSE74703 | KCTD21 | 283219 | 2 | 4 | 30 | |
| GSE74704 | KCTD21 | 283219 | 3 | 5 | 12 | |
| TCGA | KCTD21 | 283219 | 18 | 32 | 46 |
Total number of gains: 60; Total number of losses: 126; Total Number of normals: 302.
Somatic mutations of KCTD21:
Generating mutation plots.
Highly correlated genes for KCTD21:
Showing top 20/229 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KCTD21 | ENOSF1 | 0.788902 | 3 | 0 | 3 |
| KCTD21 | NAV2 | 0.768363 | 3 | 0 | 3 |
| KCTD21 | SERPINB8 | 0.758768 | 3 | 0 | 3 |
| KCTD21 | GTF3C1 | 0.748573 | 3 | 0 | 3 |
| KCTD21 | PODNL1 | 0.74726 | 3 | 0 | 3 |
| KCTD21 | HIBCH | 0.745137 | 4 | 0 | 3 |
| KCTD21 | CD2AP | 0.735093 | 4 | 0 | 4 |
| KCTD21 | ALAS1 | 0.731242 | 3 | 0 | 3 |
| KCTD21 | DIMT1 | 0.727667 | 3 | 0 | 3 |
| KCTD21 | FAM161B | 0.724694 | 3 | 0 | 3 |
| KCTD21 | CSRP2 | 0.721931 | 3 | 0 | 3 |
| KCTD21 | PKIA | 0.719817 | 3 | 0 | 3 |
| KCTD21 | ARID1B | 0.715815 | 3 | 0 | 3 |
| KCTD21 | ANKRD12 | 0.715689 | 3 | 0 | 3 |
| KCTD21 | LUC7L2 | 0.712281 | 3 | 0 | 3 |
| KCTD21 | CAPN3 | 0.711852 | 4 | 0 | 3 |
| KCTD21 | TJP1 | 0.711241 | 3 | 0 | 3 |
| KCTD21 | DYNC1I2 | 0.710985 | 4 | 0 | 4 |
| KCTD21 | EIF2B4 | 0.709747 | 5 | 0 | 5 |
| KCTD21 | ST5 | 0.708834 | 3 | 0 | 3 |
For details and further investigation, click here
