| Full name: leucine rich repeats and WD repeat domain containing 1 | Alias Symbol: DKFZp434K1815|ORCA|CENP-33 | ||
| Type: protein-coding gene | Cytoband: 7q22.1 | ||
| Entrez ID: 222229 | HGNC ID: HGNC:21769 | Ensembl Gene: ENSG00000161036 | OMIM ID: 615167 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of LRWD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | LRWD1 | 222229 | 704 | 0.7352 | 0.0000 | |
| GSE53624 | LRWD1 | 222229 | 704 | 0.8061 | 0.0000 | |
| GSE97050 | LRWD1 | 222229 | A_23_P360874 | 0.4496 | 0.1809 | |
| SRP007169 | LRWD1 | 222229 | RNAseq | 1.3062 | 0.0040 | |
| SRP008496 | LRWD1 | 222229 | RNAseq | 1.0037 | 0.0051 | |
| SRP064894 | LRWD1 | 222229 | RNAseq | 1.1259 | 0.0000 | |
| SRP133303 | LRWD1 | 222229 | RNAseq | 1.0301 | 0.0000 | |
| SRP159526 | LRWD1 | 222229 | RNAseq | 0.9125 | 0.0005 | |
| SRP193095 | LRWD1 | 222229 | RNAseq | 0.9486 | 0.0000 | |
| SRP219564 | LRWD1 | 222229 | RNAseq | 0.5252 | 0.0317 | |
| TCGA | LRWD1 | 222229 | RNAseq | 0.3039 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by LRWD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRWD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRWD1 | 222229 | 13 | 0 | 17 | |
| GSE20123 | LRWD1 | 222229 | 12 | 0 | 18 | |
| GSE43470 | LRWD1 | 222229 | 6 | 3 | 34 | |
| GSE46452 | LRWD1 | 222229 | 10 | 1 | 48 | |
| GSE47630 | LRWD1 | 222229 | 7 | 3 | 30 | |
| GSE54993 | LRWD1 | 222229 | 1 | 10 | 59 | |
| GSE54994 | LRWD1 | 222229 | 15 | 4 | 34 | |
| GSE60625 | LRWD1 | 222229 | 0 | 0 | 11 | |
| GSE74703 | LRWD1 | 222229 | 6 | 2 | 28 | |
| GSE74704 | LRWD1 | 222229 | 9 | 0 | 11 | |
| TCGA | LRWD1 | 222229 | 53 | 6 | 37 |
Total number of gains: 132; Total number of losses: 29; Total Number of normals: 327.
Somatic mutations of LRWD1:
Generating mutation plots.
Highly correlated genes for LRWD1:
Showing top 20/151 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRWD1 | KIF4A | 0.801061 | 3 | 0 | 3 |
| LRWD1 | GPRIN1 | 0.793204 | 3 | 0 | 3 |
| LRWD1 | RAD51 | 0.781245 | 3 | 0 | 3 |
| LRWD1 | E2F1 | 0.778915 | 3 | 0 | 3 |
| LRWD1 | ATAD3C | 0.773678 | 3 | 0 | 3 |
| LRWD1 | CDCA5 | 0.767757 | 3 | 0 | 3 |
| LRWD1 | LRR1 | 0.761905 | 3 | 0 | 3 |
| LRWD1 | CDC20 | 0.753216 | 3 | 0 | 3 |
| LRWD1 | TTPAL | 0.752312 | 3 | 0 | 3 |
| LRWD1 | GINS2 | 0.751595 | 3 | 0 | 3 |
| LRWD1 | CBX3 | 0.747735 | 3 | 0 | 3 |
| LRWD1 | HAUS8 | 0.74648 | 3 | 0 | 3 |
| LRWD1 | BEND3 | 0.742456 | 3 | 0 | 3 |
| LRWD1 | EXO1 | 0.742111 | 3 | 0 | 3 |
| LRWD1 | DBF4B | 0.73852 | 3 | 0 | 3 |
| LRWD1 | ASF1B | 0.736231 | 3 | 0 | 3 |
| LRWD1 | AP1S1 | 0.733799 | 3 | 0 | 3 |
| LRWD1 | ALKBH2 | 0.728724 | 3 | 0 | 3 |
| LRWD1 | MCM2 | 0.72742 | 3 | 0 | 3 |
| LRWD1 | EIF3B | 0.72555 | 3 | 0 | 3 |
For details and further investigation, click here
