| Full name: leucine rich repeat protein 1 | Alias Symbol: MGC20689|LRR-1 | ||
| Type: protein-coding gene | Cytoband: 14q21.3 | ||
| Entrez ID: 122769 | HGNC ID: HGNC:19742 | Ensembl Gene: ENSG00000165501 | OMIM ID: 609193 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of LRR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRR1 | 122769 | 235113_at | 1.1106 | 0.2560 | |
| GSE26886 | LRR1 | 122769 | 235113_at | 0.5946 | 0.0151 | |
| GSE45670 | LRR1 | 122769 | 235113_at | 0.9145 | 0.0000 | |
| GSE53622 | LRR1 | 122769 | 160646 | 0.7922 | 0.0000 | |
| GSE53624 | LRR1 | 122769 | 41636 | 1.2207 | 0.0000 | |
| GSE63941 | LRR1 | 122769 | 235113_at | 0.8724 | 0.0969 | |
| GSE77861 | LRR1 | 122769 | 235113_at | 0.8621 | 0.1536 | |
| GSE97050 | LRR1 | 122769 | A_33_P3286208 | 0.4714 | 0.2589 | |
| SRP007169 | LRR1 | 122769 | RNAseq | 1.0110 | 0.0186 | |
| SRP008496 | LRR1 | 122769 | RNAseq | 0.3794 | 0.1795 | |
| SRP064894 | LRR1 | 122769 | RNAseq | 0.8293 | 0.0001 | |
| SRP133303 | LRR1 | 122769 | RNAseq | 1.0778 | 0.0000 | |
| SRP159526 | LRR1 | 122769 | RNAseq | 0.8950 | 0.0286 | |
| SRP193095 | LRR1 | 122769 | RNAseq | 0.4993 | 0.0023 | |
| SRP219564 | LRR1 | 122769 | RNAseq | 1.3079 | 0.0176 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by LRR1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of LRR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRR1 | 122769 | 7 | 2 | 21 | |
| GSE20123 | LRR1 | 122769 | 7 | 3 | 20 | |
| GSE43470 | LRR1 | 122769 | 10 | 1 | 32 | |
| GSE46452 | LRR1 | 122769 | 16 | 3 | 40 | |
| GSE47630 | LRR1 | 122769 | 11 | 10 | 19 | |
| GSE54993 | LRR1 | 122769 | 3 | 9 | 58 | |
| GSE54994 | LRR1 | 122769 | 19 | 4 | 30 | |
| GSE60625 | LRR1 | 122769 | 0 | 2 | 9 | |
| GSE74703 | LRR1 | 122769 | 8 | 1 | 27 | |
| GSE74704 | LRR1 | 122769 | 2 | 2 | 16 | |
| TCGA | LRR1 | 122769 | 33 | 13 | 50 |
Total number of gains: 116; Total number of losses: 50; Total Number of normals: 322.
Somatic mutations of LRR1:
Generating mutation plots.
Highly correlated genes for LRR1:
Showing top 20/716 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRR1 | POLE2 | 0.865409 | 7 | 0 | 7 |
| LRR1 | ETV3 | 0.8403 | 3 | 0 | 3 |
| LRR1 | BOP1 | 0.789278 | 3 | 0 | 3 |
| LRR1 | DUSP9 | 0.777932 | 3 | 0 | 3 |
| LRR1 | CDKN3 | 0.771941 | 7 | 0 | 7 |
| LRR1 | DLGAP5 | 0.764452 | 8 | 0 | 7 |
| LRR1 | LRWD1 | 0.761905 | 3 | 0 | 3 |
| LRR1 | FEN1 | 0.760542 | 6 | 0 | 6 |
| LRR1 | CEP55 | 0.757292 | 6 | 0 | 6 |
| LRR1 | CDCA5 | 0.756623 | 8 | 0 | 8 |
| LRR1 | CBX3 | 0.75316 | 7 | 0 | 7 |
| LRR1 | CDC20 | 0.748729 | 8 | 0 | 7 |
| LRR1 | APTX | 0.742241 | 5 | 0 | 4 |
| LRR1 | C19orf48 | 0.736987 | 3 | 0 | 3 |
| LRR1 | RAD51 | 0.736603 | 8 | 0 | 8 |
| LRR1 | CDC6 | 0.73626 | 6 | 0 | 5 |
| LRR1 | TMEM251 | 0.733578 | 4 | 0 | 4 |
| LRR1 | TAF1B | 0.733371 | 3 | 0 | 3 |
| LRR1 | TTPAL | 0.733257 | 6 | 0 | 6 |
| LRR1 | HAUS8 | 0.731002 | 8 | 0 | 7 |
For details and further investigation, click here
