| Full name: testis specific serine kinase substrate | Alias Symbol: TSSKS|PPP1R161 | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 60385 | HGNC ID: HGNC:30719 | Ensembl Gene: ENSG00000126467 | OMIM ID: 608253 |
| Drug and gene relationship at DGIdb | |||
Expression of TSKS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TSKS | 60385 | 220544_at | 0.0118 | 0.9807 | |
| GSE20347 | TSKS | 60385 | 220544_at | 0.0348 | 0.6405 | |
| GSE23400 | TSKS | 60385 | 220544_at | -0.0188 | 0.5927 | |
| GSE26886 | TSKS | 60385 | 220544_at | 0.1443 | 0.3804 | |
| GSE29001 | TSKS | 60385 | 220545_s_at | -0.2569 | 0.1149 | |
| GSE38129 | TSKS | 60385 | 220544_at | -0.0317 | 0.6880 | |
| GSE45670 | TSKS | 60385 | 220544_at | 0.1055 | 0.3588 | |
| GSE53622 | TSKS | 60385 | 140303 | 0.0809 | 0.5494 | |
| GSE53624 | TSKS | 60385 | 140303 | 0.4646 | 0.0000 | |
| GSE63941 | TSKS | 60385 | 220544_at | 0.0778 | 0.7238 | |
| GSE77861 | TSKS | 60385 | 220544_at | -0.1220 | 0.3386 | |
| GSE97050 | TSKS | 60385 | A_23_P16275 | 0.2225 | 0.2635 | |
| TCGA | TSKS | 60385 | RNAseq | 2.1777 | 0.0124 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TSKS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TSKS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TSKS | 60385 | 4 | 4 | 22 | |
| GSE20123 | TSKS | 60385 | 4 | 3 | 23 | |
| GSE43470 | TSKS | 60385 | 5 | 11 | 27 | |
| GSE46452 | TSKS | 60385 | 45 | 1 | 13 | |
| GSE47630 | TSKS | 60385 | 10 | 6 | 24 | |
| GSE54993 | TSKS | 60385 | 17 | 4 | 49 | |
| GSE54994 | TSKS | 60385 | 4 | 14 | 35 | |
| GSE60625 | TSKS | 60385 | 9 | 0 | 2 | |
| GSE74703 | TSKS | 60385 | 5 | 7 | 24 | |
| GSE74704 | TSKS | 60385 | 4 | 1 | 15 | |
| TCGA | TSKS | 60385 | 14 | 18 | 64 |
Total number of gains: 121; Total number of losses: 69; Total Number of normals: 298.
Somatic mutations of TSKS:
Generating mutation plots.
Highly correlated genes for TSKS:
Showing top 20/226 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TSKS | SPRED3 | 0.792124 | 3 | 0 | 3 |
| TSKS | SCGN | 0.777419 | 4 | 0 | 3 |
| TSKS | KRT35 | 0.758643 | 3 | 0 | 3 |
| TSKS | C4BPA | 0.755324 | 3 | 0 | 3 |
| TSKS | CHD5 | 0.748776 | 4 | 0 | 4 |
| TSKS | TP53TG5 | 0.7461 | 3 | 0 | 3 |
| TSKS | MUC2 | 0.740063 | 4 | 0 | 4 |
| TSKS | ACBD4 | 0.73917 | 3 | 0 | 3 |
| TSKS | CEND1 | 0.739145 | 3 | 0 | 3 |
| TSKS | IGSF9B | 0.731089 | 3 | 0 | 3 |
| TSKS | PROCA1 | 0.730325 | 4 | 0 | 4 |
| TSKS | OR3A3 | 0.728481 | 3 | 0 | 3 |
| TSKS | TXNDC2 | 0.723833 | 3 | 0 | 3 |
| TSKS | TMEM151B | 0.720531 | 3 | 0 | 3 |
| TSKS | HHIP | 0.719173 | 3 | 0 | 3 |
| TSKS | CRTC1 | 0.71647 | 3 | 0 | 3 |
| TSKS | NKAIN4 | 0.716293 | 3 | 0 | 3 |
| TSKS | SPACA1 | 0.716279 | 3 | 0 | 3 |
| TSKS | FUZ | 0.7118 | 3 | 0 | 3 |
| TSKS | GDNF | 0.711273 | 3 | 0 | 3 |
For details and further investigation, click here
