| Full name: interleukin 21 | Alias Symbol: Za11|IL-21 | ||
| Type: protein-coding gene | Cytoband: 4q27 | ||
| Entrez ID: 59067 | HGNC ID: HGNC:6005 | Ensembl Gene: ENSG00000138684 | OMIM ID: 605384 |
| Drug and gene relationship at DGIdb | |||
IL21 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway | |
| hsa05321 | Inflammatory bowel disease (IBD) |
Expression of IL21:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL21 | 59067 | 221271_at | 0.0150 | 0.9513 | |
| GSE20347 | IL21 | 59067 | 221271_at | -0.0035 | 0.9710 | |
| GSE23400 | IL21 | 59067 | 221271_at | -0.0651 | 0.0506 | |
| GSE26886 | IL21 | 59067 | 221271_at | -0.1064 | 0.2743 | |
| GSE29001 | IL21 | 59067 | 221271_at | -0.2055 | 0.1896 | |
| GSE38129 | IL21 | 59067 | 221271_at | -0.1244 | 0.1475 | |
| GSE45670 | IL21 | 59067 | 221271_at | 0.0242 | 0.8073 | |
| GSE53622 | IL21 | 59067 | 62278 | 0.3183 | 0.0000 | |
| GSE53624 | IL21 | 59067 | 62278 | 0.2948 | 0.0033 | |
| GSE63941 | IL21 | 59067 | 221271_at | 0.0180 | 0.9126 | |
| GSE77861 | IL21 | 59067 | 221271_at | -0.1457 | 0.2586 | |
| GSE97050 | IL21 | 59067 | A_23_P167250 | 0.2795 | 0.2340 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IL21 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL21:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL21 | 59067 | 0 | 13 | 17 | |
| GSE20123 | IL21 | 59067 | 0 | 13 | 17 | |
| GSE43470 | IL21 | 59067 | 0 | 13 | 30 | |
| GSE46452 | IL21 | 59067 | 1 | 36 | 22 | |
| GSE47630 | IL21 | 59067 | 0 | 22 | 18 | |
| GSE54993 | IL21 | 59067 | 9 | 0 | 61 | |
| GSE54994 | IL21 | 59067 | 1 | 10 | 42 | |
| GSE60625 | IL21 | 59067 | 0 | 1 | 10 | |
| GSE74703 | IL21 | 59067 | 0 | 11 | 25 | |
| GSE74704 | IL21 | 59067 | 0 | 7 | 13 | |
| TCGA | IL21 | 59067 | 8 | 35 | 53 |
Total number of gains: 19; Total number of losses: 161; Total Number of normals: 308.
Somatic mutations of IL21:
Generating mutation plots.
Highly correlated genes for IL21:
Showing top 20/593 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL21 | LCN9 | 0.78161 | 3 | 0 | 3 |
| IL21 | LHFPL5 | 0.759546 | 3 | 0 | 3 |
| IL21 | OR2A5 | 0.750358 | 3 | 0 | 3 |
| IL21 | CADPS | 0.743159 | 4 | 0 | 4 |
| IL21 | NCR2 | 0.733444 | 4 | 0 | 4 |
| IL21 | FOXB1 | 0.731414 | 3 | 0 | 3 |
| IL21 | CIB3 | 0.729415 | 3 | 0 | 3 |
| IL21 | MS4A18 | 0.724104 | 3 | 0 | 3 |
| IL21 | KIR3DL3 | 0.716496 | 6 | 0 | 5 |
| IL21 | PRR34 | 0.716394 | 3 | 0 | 3 |
| IL21 | CELF4 | 0.711755 | 3 | 0 | 3 |
| IL21 | MAPK8IP2 | 0.711553 | 4 | 0 | 3 |
| IL21 | PAX3 | 0.709866 | 4 | 0 | 3 |
| IL21 | LIME1 | 0.705756 | 3 | 0 | 3 |
| IL21 | GML | 0.703485 | 5 | 0 | 5 |
| IL21 | AANAT | 0.70139 | 4 | 0 | 4 |
| IL21 | OR2T1 | 0.699285 | 3 | 0 | 3 |
| IL21 | FAM181A | 0.69735 | 3 | 0 | 3 |
| IL21 | RASL10A | 0.696474 | 4 | 0 | 3 |
| IL21 | C1QL2 | 0.694811 | 3 | 0 | 3 |
For details and further investigation, click here
