| Full name: alkaline phosphatase, intestinal | Alias Symbol: IAP | ||
| Type: protein-coding gene | Cytoband: 2q37.1 | ||
| Entrez ID: 248 | HGNC ID: HGNC:437 | Ensembl Gene: ENSG00000163295 | OMIM ID: 171740 |
| Drug and gene relationship at DGIdb | |||
Expression of ALPI:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALPI | 248 | 207140_at | -0.0704 | 0.8011 | |
| GSE20347 | ALPI | 248 | 211618_s_at | -0.1611 | 0.0052 | |
| GSE23400 | ALPI | 248 | 207140_at | -0.2203 | 0.0000 | |
| GSE26886 | ALPI | 248 | 207140_at | 0.3192 | 0.0300 | |
| GSE29001 | ALPI | 248 | 207140_at | -0.0513 | 0.7500 | |
| GSE38129 | ALPI | 248 | 211618_s_at | -0.1472 | 0.0117 | |
| GSE45670 | ALPI | 248 | 207140_at | 0.0838 | 0.3499 | |
| GSE53622 | ALPI | 248 | 83930 | 0.4229 | 0.0073 | |
| GSE53624 | ALPI | 248 | 83930 | 0.3954 | 0.0143 | |
| GSE63941 | ALPI | 248 | 207140_at | 0.1714 | 0.2763 | |
| GSE77861 | ALPI | 248 | 207140_at | -0.0946 | 0.4677 | |
| GSE97050 | ALPI | 248 | A_23_P337658 | -0.0945 | 0.7957 | |
| TCGA | ALPI | 248 | RNAseq | 0.6614 | 0.7689 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ALPI expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALPI:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALPI | 248 | 1 | 12 | 17 | |
| GSE20123 | ALPI | 248 | 1 | 12 | 17 | |
| GSE43470 | ALPI | 248 | 1 | 8 | 34 | |
| GSE46452 | ALPI | 248 | 0 | 5 | 54 | |
| GSE47630 | ALPI | 248 | 4 | 5 | 31 | |
| GSE54993 | ALPI | 248 | 3 | 2 | 65 | |
| GSE54994 | ALPI | 248 | 6 | 10 | 37 | |
| GSE60625 | ALPI | 248 | 0 | 3 | 8 | |
| GSE74703 | ALPI | 248 | 1 | 6 | 29 | |
| GSE74704 | ALPI | 248 | 1 | 5 | 14 | |
| TCGA | ALPI | 248 | 12 | 28 | 56 |
Total number of gains: 30; Total number of losses: 96; Total Number of normals: 362.
Somatic mutations of ALPI:
Generating mutation plots.
Highly correlated genes for ALPI:
Showing top 20/485 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALPI | CELA3A | 0.750644 | 4 | 0 | 4 |
| ALPI | SPEG | 0.75055 | 3 | 0 | 3 |
| ALPI | TEX35 | 0.749948 | 3 | 0 | 3 |
| ALPI | KRTAP12-2 | 0.742024 | 3 | 0 | 3 |
| ALPI | LINC00930 | 0.740211 | 3 | 0 | 3 |
| ALPI | OR2AT4 | 0.738017 | 3 | 0 | 3 |
| ALPI | CPS1-IT1 | 0.736774 | 3 | 0 | 3 |
| ALPI | ALG11 | 0.712262 | 3 | 0 | 3 |
| ALPI | TCF23 | 0.707479 | 3 | 0 | 3 |
| ALPI | LINC01101 | 0.70673 | 4 | 0 | 3 |
| ALPI | CCDC154 | 0.700603 | 6 | 0 | 5 |
| ALPI | GRIA4 | 0.69868 | 4 | 0 | 4 |
| ALPI | TECRL | 0.686834 | 3 | 0 | 3 |
| ALPI | SLC26A5 | 0.683925 | 3 | 0 | 3 |
| ALPI | LINC00221 | 0.679962 | 3 | 0 | 3 |
| ALPI | LINC00620 | 0.676426 | 3 | 0 | 3 |
| ALPI | ARHGEF33 | 0.659086 | 3 | 0 | 3 |
| ALPI | TMEM150A | 0.656181 | 4 | 0 | 3 |
| ALPI | LINC01398 | 0.654655 | 3 | 0 | 3 |
| ALPI | NLRP9 | 0.654415 | 3 | 0 | 3 |
For details and further investigation, click here
