| Full name: aminomethyltransferase | Alias Symbol: GCST|NKH | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 275 | HGNC ID: HGNC:473 | Ensembl Gene: ENSG00000145020 | OMIM ID: 238310 |
| Drug and gene relationship at DGIdb | |||
Expression of AMT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AMT | 275 | 204294_at | -0.4565 | 0.3853 | |
| GSE20347 | AMT | 275 | 204294_at | -0.0926 | 0.5293 | |
| GSE23400 | AMT | 275 | 204294_at | -0.2905 | 0.0000 | |
| GSE26886 | AMT | 275 | 204294_at | -0.1210 | 0.6509 | |
| GSE29001 | AMT | 275 | 204294_at | -0.2617 | 0.2502 | |
| GSE38129 | AMT | 275 | 204294_at | -0.4839 | 0.0012 | |
| GSE45670 | AMT | 275 | 204294_at | -0.7969 | 0.0000 | |
| GSE53622 | AMT | 275 | 38779 | -0.1207 | 0.0902 | |
| GSE53624 | AMT | 275 | 38779 | -0.4796 | 0.0000 | |
| GSE63941 | AMT | 275 | 204294_at | 0.0785 | 0.9047 | |
| GSE77861 | AMT | 275 | 204294_at | -0.0125 | 0.9482 | |
| GSE97050 | AMT | 275 | A_24_P174503 | -0.5299 | 0.1377 | |
| SRP064894 | AMT | 275 | RNAseq | -0.3718 | 0.0606 | |
| SRP133303 | AMT | 275 | RNAseq | -0.7010 | 0.0015 | |
| SRP159526 | AMT | 275 | RNAseq | -0.6844 | 0.1077 | |
| SRP193095 | AMT | 275 | RNAseq | -0.2815 | 0.2215 | |
| SRP219564 | AMT | 275 | RNAseq | -0.3626 | 0.5413 | |
| TCGA | AMT | 275 | RNAseq | -0.9315 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by AMT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AMT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AMT | 275 | 0 | 18 | 12 | |
| GSE20123 | AMT | 275 | 0 | 19 | 11 | |
| GSE43470 | AMT | 275 | 0 | 18 | 25 | |
| GSE46452 | AMT | 275 | 2 | 16 | 41 | |
| GSE47630 | AMT | 275 | 1 | 24 | 15 | |
| GSE54993 | AMT | 275 | 6 | 2 | 62 | |
| GSE54994 | AMT | 275 | 0 | 36 | 17 | |
| GSE60625 | AMT | 275 | 5 | 0 | 6 | |
| GSE74703 | AMT | 275 | 0 | 14 | 22 | |
| GSE74704 | AMT | 275 | 0 | 12 | 8 | |
| TCGA | AMT | 275 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 237; Total Number of normals: 237.
Somatic mutations of AMT:
Generating mutation plots.
Highly correlated genes for AMT:
Showing top 20/499 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AMT | MIR100HG | 0.748236 | 3 | 0 | 3 |
| AMT | MTFR1L | 0.709671 | 3 | 0 | 3 |
| AMT | ZBTB47 | 0.704593 | 3 | 0 | 3 |
| AMT | ZC3H6 | 0.701323 | 3 | 0 | 3 |
| AMT | C7 | 0.697054 | 5 | 0 | 5 |
| AMT | FYCO1 | 0.69613 | 4 | 0 | 4 |
| AMT | ZBTB20 | 0.682384 | 5 | 0 | 5 |
| AMT | CLIP3 | 0.677879 | 6 | 0 | 6 |
| AMT | ABCA6 | 0.674767 | 4 | 0 | 3 |
| AMT | FBLN1 | 0.674379 | 4 | 0 | 4 |
| AMT | MITF | 0.670997 | 6 | 0 | 6 |
| AMT | FRRS1L | 0.668057 | 4 | 0 | 3 |
| AMT | MEOX2 | 0.665945 | 4 | 0 | 4 |
| AMT | CRBN | 0.663896 | 4 | 0 | 4 |
| AMT | PGM5 | 0.662644 | 7 | 0 | 7 |
| AMT | EZH1 | 0.660237 | 7 | 0 | 6 |
| AMT | OGN | 0.659881 | 5 | 0 | 4 |
| AMT | RSPO3 | 0.659495 | 3 | 0 | 3 |
| AMT | REM1 | 0.657841 | 6 | 0 | 5 |
| AMT | CACNA1H | 0.657479 | 6 | 0 | 5 |
For details and further investigation, click here
