| Full name: aldehyde oxidase 1 | Alias Symbol: AO|AOH1 | ||
| Type: protein-coding gene | Cytoband: 2q33.1 | ||
| Entrez ID: 316 | HGNC ID: HGNC:553 | Ensembl Gene: ENSG00000138356 | OMIM ID: 602841 |
| Drug and gene relationship at DGIdb | |||
AOX1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway |
Expression of AOX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AOX1 | 316 | 205083_at | -1.8333 | 0.0842 | |
| GSE20347 | AOX1 | 316 | 205082_s_at | -0.1712 | 0.0391 | |
| GSE23400 | AOX1 | 316 | 205082_s_at | -0.2131 | 0.0000 | |
| GSE26886 | AOX1 | 316 | 205082_s_at | -0.0107 | 0.9356 | |
| GSE29001 | AOX1 | 316 | 205083_at | -0.3429 | 0.0902 | |
| GSE38129 | AOX1 | 316 | 205082_s_at | -0.4649 | 0.0001 | |
| GSE45670 | AOX1 | 316 | 205082_s_at | -1.0760 | 0.0001 | |
| GSE53622 | AOX1 | 316 | 76231 | -1.4660 | 0.0000 | |
| GSE53624 | AOX1 | 316 | 76231 | -1.3425 | 0.0000 | |
| GSE63941 | AOX1 | 316 | 205082_s_at | -0.9221 | 0.0211 | |
| GSE77861 | AOX1 | 316 | 205082_s_at | -0.2380 | 0.1159 | |
| GSE97050 | AOX1 | 316 | A_33_P3354414 | 0.2261 | 0.3928 | |
| SRP064894 | AOX1 | 316 | RNAseq | -0.8928 | 0.0859 | |
| SRP133303 | AOX1 | 316 | RNAseq | -1.8118 | 0.0005 | |
| SRP159526 | AOX1 | 316 | RNAseq | -0.4377 | 0.4147 | |
| SRP193095 | AOX1 | 316 | RNAseq | 0.3741 | 0.2367 | |
| SRP219564 | AOX1 | 316 | RNAseq | -0.3199 | 0.7277 | |
| TCGA | AOX1 | 316 | RNAseq | -1.4561 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by AOX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AOX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AOX1 | 316 | 6 | 4 | 20 | |
| GSE20123 | AOX1 | 316 | 6 | 4 | 20 | |
| GSE43470 | AOX1 | 316 | 2 | 1 | 40 | |
| GSE46452 | AOX1 | 316 | 1 | 4 | 54 | |
| GSE47630 | AOX1 | 316 | 4 | 5 | 31 | |
| GSE54993 | AOX1 | 316 | 0 | 3 | 67 | |
| GSE54994 | AOX1 | 316 | 10 | 8 | 35 | |
| GSE60625 | AOX1 | 316 | 0 | 3 | 8 | |
| GSE74703 | AOX1 | 316 | 2 | 1 | 33 | |
| GSE74704 | AOX1 | 316 | 3 | 2 | 15 | |
| TCGA | AOX1 | 316 | 23 | 10 | 63 |
Total number of gains: 57; Total number of losses: 45; Total Number of normals: 386.
Somatic mutations of AOX1:
Generating mutation plots.
Highly correlated genes for AOX1:
Showing top 20/716 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AOX1 | LINC01279 | 0.776308 | 3 | 0 | 3 |
| AOX1 | GPIHBP1 | 0.771362 | 3 | 0 | 3 |
| AOX1 | TBX5-AS1 | 0.7368 | 3 | 0 | 3 |
| AOX1 | OLFML3 | 0.72839 | 4 | 0 | 4 |
| AOX1 | ITGBL1 | 0.717606 | 3 | 0 | 3 |
| AOX1 | MILR1 | 0.706167 | 3 | 0 | 3 |
| AOX1 | NEGR1 | 0.704113 | 5 | 0 | 5 |
| AOX1 | PLCXD3 | 0.69757 | 5 | 0 | 4 |
| AOX1 | C1QTNF2 | 0.696363 | 5 | 0 | 5 |
| AOX1 | NEXN | 0.687993 | 5 | 0 | 5 |
| AOX1 | TRPV2 | 0.687445 | 3 | 0 | 3 |
| AOX1 | LINC01082 | 0.680465 | 5 | 0 | 5 |
| AOX1 | MGARP | 0.678853 | 3 | 0 | 3 |
| AOX1 | RAB3C | 0.675307 | 3 | 0 | 3 |
| AOX1 | XKR4 | 0.675098 | 4 | 0 | 4 |
| AOX1 | MAMDC2 | 0.670084 | 6 | 0 | 5 |
| AOX1 | PDE2A | 0.669729 | 8 | 0 | 6 |
| AOX1 | LYVE1 | 0.666804 | 9 | 0 | 8 |
| AOX1 | TMOD2 | 0.665953 | 4 | 0 | 4 |
| AOX1 | EBF1 | 0.665939 | 6 | 0 | 6 |
For details and further investigation, click here
