| Full name: lymphatic vessel endothelial hyaluronan receptor 1 | Alias Symbol: LYVE-1 | ||
| Type: protein-coding gene | Cytoband: 11p15.4 | ||
| Entrez ID: 10894 | HGNC ID: HGNC:14687 | Ensembl Gene: ENSG00000133800 | OMIM ID: 605702 |
| Drug and gene relationship at DGIdb | |||
Expression of LYVE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LYVE1 | 10894 | 219059_s_at | -1.8199 | 0.1861 | |
| GSE20347 | LYVE1 | 10894 | 219059_s_at | -0.0869 | 0.4682 | |
| GSE23400 | LYVE1 | 10894 | 219059_s_at | -0.2836 | 0.0005 | |
| GSE26886 | LYVE1 | 10894 | 219059_s_at | -0.0642 | 0.7698 | |
| GSE29001 | LYVE1 | 10894 | 219059_s_at | -0.1224 | 0.4243 | |
| GSE38129 | LYVE1 | 10894 | 219059_s_at | -0.9328 | 0.0011 | |
| GSE45670 | LYVE1 | 10894 | 219059_s_at | -2.0328 | 0.0000 | |
| GSE53622 | LYVE1 | 10894 | 100753 | -2.6239 | 0.0000 | |
| GSE53624 | LYVE1 | 10894 | 100753 | -2.0072 | 0.0000 | |
| GSE63941 | LYVE1 | 10894 | 219059_s_at | 0.0306 | 0.8757 | |
| GSE77861 | LYVE1 | 10894 | 219059_s_at | -0.1363 | 0.2618 | |
| GSE97050 | LYVE1 | 10894 | A_23_P150457 | -0.5555 | 0.2157 | |
| SRP007169 | LYVE1 | 10894 | RNAseq | 0.7888 | 0.1923 | |
| SRP064894 | LYVE1 | 10894 | RNAseq | -0.4979 | 0.3695 | |
| SRP133303 | LYVE1 | 10894 | RNAseq | -2.7917 | 0.0000 | |
| SRP159526 | LYVE1 | 10894 | RNAseq | -0.6831 | 0.2941 | |
| SRP193095 | LYVE1 | 10894 | RNAseq | -0.2892 | 0.4990 | |
| SRP219564 | LYVE1 | 10894 | RNAseq | -0.0450 | 0.9668 | |
| TCGA | LYVE1 | 10894 | RNAseq | -1.4045 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by LYVE1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LYVE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LYVE1 | 10894 | 0 | 9 | 21 | |
| GSE20123 | LYVE1 | 10894 | 0 | 10 | 20 | |
| GSE43470 | LYVE1 | 10894 | 1 | 6 | 36 | |
| GSE46452 | LYVE1 | 10894 | 7 | 5 | 47 | |
| GSE47630 | LYVE1 | 10894 | 3 | 11 | 26 | |
| GSE54993 | LYVE1 | 10894 | 3 | 1 | 66 | |
| GSE54994 | LYVE1 | 10894 | 3 | 12 | 38 | |
| GSE60625 | LYVE1 | 10894 | 0 | 0 | 11 | |
| GSE74703 | LYVE1 | 10894 | 1 | 4 | 31 | |
| GSE74704 | LYVE1 | 10894 | 0 | 7 | 13 | |
| TCGA | LYVE1 | 10894 | 11 | 34 | 51 |
Total number of gains: 29; Total number of losses: 99; Total Number of normals: 360.
Somatic mutations of LYVE1:
Generating mutation plots.
Highly correlated genes for LYVE1:
Showing top 20/1240 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LYVE1 | CLEC3B | 0.838704 | 3 | 0 | 3 |
| LYVE1 | CCL14 | 0.824127 | 3 | 0 | 3 |
| LYVE1 | AFF3 | 0.807975 | 3 | 0 | 3 |
| LYVE1 | ABCA6 | 0.794757 | 8 | 0 | 8 |
| LYVE1 | GIMAP5 | 0.789388 | 3 | 0 | 3 |
| LYVE1 | ANGPTL1 | 0.787822 | 5 | 0 | 5 |
| LYVE1 | LRFN5 | 0.779057 | 4 | 0 | 4 |
| LYVE1 | ZCWPW2 | 0.769883 | 3 | 0 | 3 |
| LYVE1 | OGN | 0.768598 | 10 | 0 | 9 |
| LYVE1 | C1QTNF7 | 0.767061 | 6 | 0 | 6 |
| LYVE1 | TMEM100 | 0.766488 | 8 | 0 | 7 |
| LYVE1 | ABCA8 | 0.766346 | 8 | 0 | 8 |
| LYVE1 | MFAP4 | 0.764038 | 9 | 0 | 9 |
| LYVE1 | PDE1A | 0.762225 | 8 | 0 | 7 |
| LYVE1 | C1QTNF2 | 0.761194 | 4 | 0 | 4 |
| LYVE1 | CCL23 | 0.761155 | 4 | 0 | 4 |
| LYVE1 | TNFSF12 | 0.760936 | 3 | 0 | 3 |
| LYVE1 | MMRN1 | 0.760855 | 9 | 0 | 8 |
| LYVE1 | PLAC9 | 0.755109 | 5 | 0 | 4 |
| LYVE1 | ITPR1 | 0.75241 | 7 | 0 | 7 |
For details and further investigation, click here
