| Full name: transient receptor potential cation channel subfamily V member 2 | Alias Symbol: VRL|VRL-1|VRL1 | ||
| Type: protein-coding gene | Cytoband: 17p11.2 | ||
| Entrez ID: 51393 | HGNC ID: HGNC:18082 | Ensembl Gene: ENSG00000187688 | OMIM ID: 606676 |
| Drug and gene relationship at DGIdb | |||
TRPV2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04750 | Inflammatory mediator regulation of TRP channels |
Expression of TRPV2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRPV2 | 51393 | 219282_s_at | 0.3184 | 0.6553 | |
| GSE20347 | TRPV2 | 51393 | 219282_s_at | 0.2489 | 0.0687 | |
| GSE23400 | TRPV2 | 51393 | 219282_s_at | 0.0446 | 0.2759 | |
| GSE26886 | TRPV2 | 51393 | 219282_s_at | 0.1155 | 0.6582 | |
| GSE29001 | TRPV2 | 51393 | 219282_s_at | 0.0761 | 0.6933 | |
| GSE38129 | TRPV2 | 51393 | 219282_s_at | 0.1232 | 0.5297 | |
| GSE45670 | TRPV2 | 51393 | 219282_s_at | -0.1302 | 0.4412 | |
| GSE53622 | TRPV2 | 51393 | 56727 | 0.4956 | 0.0000 | |
| GSE53624 | TRPV2 | 51393 | 56727 | 0.6842 | 0.0000 | |
| GSE63941 | TRPV2 | 51393 | 219282_s_at | -2.9890 | 0.0009 | |
| GSE77861 | TRPV2 | 51393 | 219282_s_at | -0.0452 | 0.7271 | |
| GSE97050 | TRPV2 | 51393 | A_23_P207911 | 0.2490 | 0.4427 | |
| SRP007169 | TRPV2 | 51393 | RNAseq | 2.3900 | 0.0025 | |
| SRP008496 | TRPV2 | 51393 | RNAseq | 2.3551 | 0.0001 | |
| SRP064894 | TRPV2 | 51393 | RNAseq | 0.9515 | 0.0021 | |
| SRP133303 | TRPV2 | 51393 | RNAseq | 0.1861 | 0.2740 | |
| SRP159526 | TRPV2 | 51393 | RNAseq | -0.1852 | 0.7108 | |
| SRP193095 | TRPV2 | 51393 | RNAseq | 0.7788 | 0.0003 | |
| SRP219564 | TRPV2 | 51393 | RNAseq | 0.6209 | 0.2322 | |
| TCGA | TRPV2 | 51393 | RNAseq | -0.0210 | 0.8765 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by TRPV2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRPV2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRPV2 | 51393 | 3 | 3 | 24 | |
| GSE20123 | TRPV2 | 51393 | 3 | 4 | 23 | |
| GSE43470 | TRPV2 | 51393 | 2 | 5 | 36 | |
| GSE46452 | TRPV2 | 51393 | 34 | 1 | 24 | |
| GSE47630 | TRPV2 | 51393 | 7 | 1 | 32 | |
| GSE54993 | TRPV2 | 51393 | 3 | 3 | 64 | |
| GSE54994 | TRPV2 | 51393 | 6 | 5 | 42 | |
| GSE60625 | TRPV2 | 51393 | 4 | 0 | 7 | |
| GSE74703 | TRPV2 | 51393 | 2 | 2 | 32 | |
| GSE74704 | TRPV2 | 51393 | 2 | 1 | 17 | |
| TCGA | TRPV2 | 51393 | 18 | 23 | 55 |
Total number of gains: 84; Total number of losses: 48; Total Number of normals: 356.
Somatic mutations of TRPV2:
Generating mutation plots.
Highly correlated genes for TRPV2:
Showing top 20/928 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRPV2 | C19orf38 | 0.791852 | 3 | 0 | 3 |
| TRPV2 | FCGR3A | 0.790963 | 3 | 0 | 3 |
| TRPV2 | LRRC8C | 0.751475 | 3 | 0 | 3 |
| TRPV2 | CERKL | 0.74503 | 3 | 0 | 3 |
| TRPV2 | SUFU | 0.743643 | 3 | 0 | 3 |
| TRPV2 | GIMAP7 | 0.73893 | 3 | 0 | 3 |
| TRPV2 | IL2RA | 0.735974 | 4 | 0 | 4 |
| TRPV2 | GAS6 | 0.732305 | 4 | 0 | 4 |
| TRPV2 | TMEM200A | 0.731079 | 7 | 0 | 7 |
| TRPV2 | SNX25 | 0.730689 | 3 | 0 | 3 |
| TRPV2 | PDCD1LG2 | 0.723804 | 5 | 0 | 4 |
| TRPV2 | TYROBP | 0.72349 | 11 | 0 | 9 |
| TRPV2 | NEK6 | 0.717998 | 4 | 0 | 3 |
| TRPV2 | ANKRD44 | 0.715733 | 5 | 0 | 4 |
| TRPV2 | FGF7 | 0.714165 | 5 | 0 | 4 |
| TRPV2 | TMEM119 | 0.713715 | 8 | 0 | 8 |
| TRPV2 | MS4A14 | 0.712705 | 3 | 0 | 3 |
| TRPV2 | C1QA | 0.712491 | 11 | 0 | 10 |
| TRPV2 | ABL2 | 0.710711 | 4 | 0 | 4 |
| TRPV2 | MCAM | 0.707635 | 5 | 0 | 5 |
For details and further investigation, click here
