| Full name: adaptor related protein complex 4 subunit sigma 1 | Alias Symbol: CLA20|AP47B|SPG52 | ||
| Type: protein-coding gene | Cytoband: 14q12 | ||
| Entrez ID: 11154 | HGNC ID: HGNC:575 | Ensembl Gene: ENSG00000100478 | OMIM ID: 607243 |
| Drug and gene relationship at DGIdb | |||
Expression of AP4S1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AP4S1 | 11154 | 235647_at | 0.6917 | 0.4554 | |
| GSE20347 | AP4S1 | 11154 | 210952_at | -0.0930 | 0.1910 | |
| GSE23400 | AP4S1 | 11154 | 210952_at | -0.1201 | 0.0002 | |
| GSE26886 | AP4S1 | 11154 | 235647_at | 1.3709 | 0.0000 | |
| GSE29001 | AP4S1 | 11154 | 210952_at | -0.1767 | 0.1399 | |
| GSE38129 | AP4S1 | 11154 | 210952_at | -0.1959 | 0.0244 | |
| GSE45670 | AP4S1 | 11154 | 235647_at | 0.1918 | 0.3944 | |
| GSE53622 | AP4S1 | 11154 | 142080 | 0.4649 | 0.0055 | |
| GSE53624 | AP4S1 | 11154 | 142080 | 0.6831 | 0.0008 | |
| GSE63941 | AP4S1 | 11154 | 235647_at | 0.8429 | 0.2806 | |
| GSE77861 | AP4S1 | 11154 | 210952_at | -0.0993 | 0.3282 | |
| GSE97050 | AP4S1 | 11154 | A_24_P401645 | 0.1477 | 0.7032 | |
| SRP007169 | AP4S1 | 11154 | RNAseq | 0.9377 | 0.0435 | |
| SRP008496 | AP4S1 | 11154 | RNAseq | 1.0218 | 0.0051 | |
| SRP064894 | AP4S1 | 11154 | RNAseq | 0.4969 | 0.0002 | |
| SRP133303 | AP4S1 | 11154 | RNAseq | 0.2640 | 0.0980 | |
| SRP159526 | AP4S1 | 11154 | RNAseq | 0.3295 | 0.1401 | |
| SRP193095 | AP4S1 | 11154 | RNAseq | 0.2619 | 0.0212 | |
| SRP219564 | AP4S1 | 11154 | RNAseq | 0.2340 | 0.3762 | |
| TCGA | AP4S1 | 11154 | RNAseq | 0.1931 | 0.0840 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by AP4S1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AP4S1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AP4S1 | 11154 | 9 | 4 | 17 | |
| GSE20123 | AP4S1 | 11154 | 9 | 4 | 17 | |
| GSE43470 | AP4S1 | 11154 | 10 | 2 | 31 | |
| GSE46452 | AP4S1 | 11154 | 16 | 2 | 41 | |
| GSE47630 | AP4S1 | 11154 | 11 | 10 | 19 | |
| GSE54993 | AP4S1 | 11154 | 3 | 11 | 56 | |
| GSE54994 | AP4S1 | 11154 | 19 | 5 | 29 | |
| GSE60625 | AP4S1 | 11154 | 0 | 2 | 9 | |
| GSE74703 | AP4S1 | 11154 | 9 | 2 | 25 | |
| GSE74704 | AP4S1 | 11154 | 4 | 3 | 13 | |
| TCGA | AP4S1 | 11154 | 33 | 14 | 49 |
Total number of gains: 123; Total number of losses: 59; Total Number of normals: 306.
Somatic mutations of AP4S1:
Generating mutation plots.
Highly correlated genes for AP4S1:
Showing top 20/643 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AP4S1 | P2RX7 | 0.762176 | 3 | 0 | 3 |
| AP4S1 | GNAS-AS1 | 0.740401 | 3 | 0 | 3 |
| AP4S1 | IL18BP | 0.739502 | 7 | 0 | 7 |
| AP4S1 | CDH24 | 0.732904 | 3 | 0 | 3 |
| AP4S1 | IBA57 | 0.73282 | 6 | 0 | 6 |
| AP4S1 | TNFSF8 | 0.72517 | 5 | 0 | 5 |
| AP4S1 | ZNF530 | 0.722851 | 3 | 0 | 3 |
| AP4S1 | SERPINA6 | 0.715827 | 4 | 0 | 4 |
| AP4S1 | DRICH1 | 0.705227 | 4 | 0 | 4 |
| AP4S1 | SNORD8 | 0.704598 | 3 | 0 | 3 |
| AP4S1 | NEK6 | 0.703566 | 3 | 0 | 3 |
| AP4S1 | ATN1 | 0.700299 | 3 | 0 | 3 |
| AP4S1 | DEFA4 | 0.698287 | 5 | 0 | 5 |
| AP4S1 | TOX4 | 0.698153 | 3 | 0 | 3 |
| AP4S1 | C8A | 0.68874 | 5 | 0 | 5 |
| AP4S1 | DNAAF1 | 0.688466 | 4 | 0 | 4 |
| AP4S1 | L3HYPDH | 0.688413 | 4 | 0 | 4 |
| AP4S1 | ZNF460 | 0.686761 | 6 | 0 | 6 |
| AP4S1 | KIR2DS3 | 0.686293 | 4 | 0 | 4 |
| AP4S1 | BRINP2 | 0.685037 | 5 | 0 | 5 |
For details and further investigation, click here
