| Full name: trans-L-3-hydroxyproline dehydratase | Alias Symbol: FLJ25436 | ||
| Type: protein-coding gene | Cytoband: 14q23.1 | ||
| Entrez ID: 112849 | HGNC ID: HGNC:20488 | Ensembl Gene: ENSG00000126790 | OMIM ID: 614811 |
| Drug and gene relationship at DGIdb | |||
Expression of L3HYPDH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | L3HYPDH | 112849 | 227699_at | 0.5876 | 0.3386 | |
| GSE26886 | L3HYPDH | 112849 | 227699_at | 1.0208 | 0.0021 | |
| GSE45670 | L3HYPDH | 112849 | 227699_at | 0.3565 | 0.2402 | |
| GSE53622 | L3HYPDH | 112849 | 39687 | 0.9117 | 0.0000 | |
| GSE53624 | L3HYPDH | 112849 | 39687 | 1.1635 | 0.0000 | |
| GSE63941 | L3HYPDH | 112849 | 227699_at | -0.5282 | 0.5559 | |
| GSE77861 | L3HYPDH | 112849 | 227699_at | 0.4496 | 0.1406 | |
| SRP007169 | L3HYPDH | 112849 | RNAseq | 1.5012 | 0.0110 | |
| SRP008496 | L3HYPDH | 112849 | RNAseq | 1.9573 | 0.0000 | |
| SRP064894 | L3HYPDH | 112849 | RNAseq | 0.6277 | 0.0009 | |
| SRP133303 | L3HYPDH | 112849 | RNAseq | 0.3336 | 0.1055 | |
| SRP159526 | L3HYPDH | 112849 | RNAseq | 0.1092 | 0.6780 | |
| SRP193095 | L3HYPDH | 112849 | RNAseq | 0.8567 | 0.0000 | |
| SRP219564 | L3HYPDH | 112849 | RNAseq | 0.3901 | 0.3304 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by L3HYPDH expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of L3HYPDH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | L3HYPDH | 112849 | 8 | 3 | 19 | |
| GSE20123 | L3HYPDH | 112849 | 7 | 3 | 20 | |
| GSE43470 | L3HYPDH | 112849 | 8 | 2 | 33 | |
| GSE46452 | L3HYPDH | 112849 | 16 | 3 | 40 | |
| GSE47630 | L3HYPDH | 112849 | 11 | 9 | 20 | |
| GSE54993 | L3HYPDH | 112849 | 3 | 8 | 59 | |
| GSE54994 | L3HYPDH | 112849 | 19 | 4 | 30 | |
| GSE60625 | L3HYPDH | 112849 | 0 | 2 | 9 | |
| GSE74703 | L3HYPDH | 112849 | 7 | 2 | 27 | |
| GSE74704 | L3HYPDH | 112849 | 3 | 2 | 15 | |
| TCGA | L3HYPDH | 112849 | 32 | 14 | 50 |
Total number of gains: 114; Total number of losses: 52; Total Number of normals: 322.
Somatic mutations of L3HYPDH:
Generating mutation plots.
Highly correlated genes for L3HYPDH:
Showing top 20/722 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| L3HYPDH | PSMC1 | 0.756159 | 4 | 0 | 4 |
| L3HYPDH | EML5 | 0.74242 | 3 | 0 | 3 |
| L3HYPDH | ZNF114 | 0.731288 | 4 | 0 | 4 |
| L3HYPDH | SLCO1B3 | 0.710089 | 3 | 0 | 3 |
| L3HYPDH | NUP35 | 0.710046 | 3 | 0 | 3 |
| L3HYPDH | PDPN | 0.709347 | 3 | 0 | 3 |
| L3HYPDH | MSANTD3 | 0.708533 | 5 | 0 | 5 |
| L3HYPDH | SLC4A1AP | 0.69672 | 5 | 0 | 5 |
| L3HYPDH | GMPR2 | 0.690533 | 3 | 0 | 3 |
| L3HYPDH | AP4S1 | 0.688413 | 4 | 0 | 4 |
| L3HYPDH | SUPT16H | 0.677818 | 6 | 0 | 6 |
| L3HYPDH | NUTF2 | 0.677167 | 5 | 0 | 4 |
| L3HYPDH | FJX1 | 0.672952 | 6 | 0 | 6 |
| L3HYPDH | SLC15A4 | 0.669353 | 3 | 0 | 3 |
| L3HYPDH | ADAMTS2 | 0.669119 | 4 | 0 | 4 |
| L3HYPDH | AGPS | 0.668947 | 6 | 0 | 6 |
| L3HYPDH | ERH | 0.6681 | 5 | 0 | 5 |
| L3HYPDH | CNTNAP2 | 0.663427 | 4 | 0 | 3 |
| L3HYPDH | ARSI | 0.662606 | 4 | 0 | 4 |
| L3HYPDH | CCDC51 | 0.661961 | 4 | 0 | 4 |
For details and further investigation, click here
