| Full name: NIMA related kinase 6 | Alias Symbol: SID6-1512 | ||
| Type: protein-coding gene | Cytoband: 9q33.3 | ||
| Entrez ID: 10783 | HGNC ID: HGNC:7749 | Ensembl Gene: ENSG00000119408 | OMIM ID: 604884 |
| Drug and gene relationship at DGIdb | |||
Expression of NEK6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NEK6 | 10783 | 223158_s_at | 0.9490 | 0.1174 | |
| GSE26886 | NEK6 | 10783 | 223158_s_at | 2.1978 | 0.0000 | |
| GSE45670 | NEK6 | 10783 | 223158_s_at | 0.7712 | 0.0009 | |
| GSE53622 | NEK6 | 10783 | 9740 | 0.4830 | 0.0000 | |
| GSE53624 | NEK6 | 10783 | 9740 | 0.6997 | 0.0000 | |
| GSE63941 | NEK6 | 10783 | 223158_s_at | -0.6767 | 0.4706 | |
| GSE77861 | NEK6 | 10783 | 223561_at | -0.0792 | 0.4971 | |
| GSE97050 | NEK6 | 10783 | A_23_P216920 | 0.5314 | 0.1093 | |
| SRP007169 | NEK6 | 10783 | RNAseq | 3.8613 | 0.0000 | |
| SRP008496 | NEK6 | 10783 | RNAseq | 3.5802 | 0.0000 | |
| SRP064894 | NEK6 | 10783 | RNAseq | 1.5056 | 0.0000 | |
| SRP133303 | NEK6 | 10783 | RNAseq | 0.6056 | 0.0028 | |
| SRP159526 | NEK6 | 10783 | RNAseq | 0.6729 | 0.0494 | |
| SRP193095 | NEK6 | 10783 | RNAseq | 0.4953 | 0.1067 | |
| SRP219564 | NEK6 | 10783 | RNAseq | 1.2619 | 0.0267 | |
| TCGA | NEK6 | 10783 | RNAseq | -0.1366 | 0.1100 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by NEK6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NEK6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NEK6 | 10783 | 4 | 8 | 18 | |
| GSE20123 | NEK6 | 10783 | 4 | 8 | 18 | |
| GSE43470 | NEK6 | 10783 | 5 | 5 | 33 | |
| GSE46452 | NEK6 | 10783 | 6 | 13 | 40 | |
| GSE47630 | NEK6 | 10783 | 3 | 16 | 21 | |
| GSE54993 | NEK6 | 10783 | 3 | 3 | 64 | |
| GSE54994 | NEK6 | 10783 | 9 | 10 | 34 | |
| GSE60625 | NEK6 | 10783 | 0 | 0 | 11 | |
| GSE74703 | NEK6 | 10783 | 5 | 3 | 28 | |
| GSE74704 | NEK6 | 10783 | 2 | 6 | 12 | |
| TCGA | NEK6 | 10783 | 27 | 25 | 44 |
Total number of gains: 68; Total number of losses: 97; Total Number of normals: 323.
Somatic mutations of NEK6:
Generating mutation plots.
Highly correlated genes for NEK6:
Showing top 20/1015 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NEK6 | BIRC3 | 0.79888 | 3 | 0 | 3 |
| NEK6 | KRTCAP2 | 0.798252 | 3 | 0 | 3 |
| NEK6 | IL18RAP | 0.776241 | 3 | 0 | 3 |
| NEK6 | POFUT1 | 0.759434 | 3 | 0 | 3 |
| NEK6 | CCT6A | 0.751632 | 3 | 0 | 3 |
| NEK6 | KHSRP | 0.751242 | 3 | 0 | 3 |
| NEK6 | CXCL16 | 0.746424 | 3 | 0 | 3 |
| NEK6 | CARD10 | 0.746326 | 3 | 0 | 3 |
| NEK6 | SLC7A6OS | 0.745467 | 3 | 0 | 3 |
| NEK6 | SRRD | 0.744679 | 3 | 0 | 3 |
| NEK6 | MORC2 | 0.744168 | 3 | 0 | 3 |
| NEK6 | ALPK2 | 0.743047 | 3 | 0 | 3 |
| NEK6 | MRPL52 | 0.742786 | 3 | 0 | 3 |
| NEK6 | HEXA | 0.742507 | 4 | 0 | 4 |
| NEK6 | CDCA4 | 0.741593 | 4 | 0 | 4 |
| NEK6 | PLCG1 | 0.740992 | 3 | 0 | 3 |
| NEK6 | PREX1 | 0.740225 | 3 | 0 | 3 |
| NEK6 | DEPDC1 | 0.736769 | 3 | 0 | 3 |
| NEK6 | DHRS13 | 0.736283 | 3 | 0 | 3 |
| NEK6 | DERL1 | 0.735473 | 4 | 0 | 4 |
For details and further investigation, click here
