| Full name: complement C8 alpha chain | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p32.2 | ||
| Entrez ID: 731 | HGNC ID: HGNC:1352 | Ensembl Gene: ENSG00000157131 | OMIM ID: 120950 |
| Drug and gene relationship at DGIdb | |||
Expression of C8A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | C8A | 731 | 206305_s_at | 0.1118 | 0.6321 | |
| GSE20347 | C8A | 731 | 206305_s_at | -0.0134 | 0.8891 | |
| GSE23400 | C8A | 731 | 206305_s_at | -0.0729 | 0.0241 | |
| GSE26886 | C8A | 731 | 206305_s_at | 0.0201 | 0.8580 | |
| GSE29001 | C8A | 731 | 206305_s_at | -0.2208 | 0.1040 | |
| GSE38129 | C8A | 731 | 206305_s_at | -0.0374 | 0.6455 | |
| GSE45670 | C8A | 731 | 206305_s_at | 0.0139 | 0.8962 | |
| GSE53622 | C8A | 731 | 10905 | 0.1840 | 0.0377 | |
| GSE53624 | C8A | 731 | 10905 | 0.2309 | 0.0004 | |
| GSE63941 | C8A | 731 | 206305_s_at | 0.2778 | 0.0371 | |
| GSE77861 | C8A | 731 | 206305_s_at | -0.0689 | 0.4641 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by C8A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of C8A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | C8A | 731 | 3 | 5 | 22 | |
| GSE20123 | C8A | 731 | 3 | 4 | 23 | |
| GSE43470 | C8A | 731 | 6 | 1 | 36 | |
| GSE46452 | C8A | 731 | 2 | 1 | 56 | |
| GSE47630 | C8A | 731 | 8 | 4 | 28 | |
| GSE54993 | C8A | 731 | 0 | 0 | 70 | |
| GSE54994 | C8A | 731 | 9 | 2 | 42 | |
| GSE60625 | C8A | 731 | 0 | 0 | 11 | |
| GSE74703 | C8A | 731 | 5 | 1 | 30 | |
| GSE74704 | C8A | 731 | 2 | 0 | 18 | |
| TCGA | C8A | 731 | 10 | 18 | 68 |
Total number of gains: 48; Total number of losses: 36; Total Number of normals: 404.
Somatic mutations of C8A:
Generating mutation plots.
Highly correlated genes for C8A:
Showing top 20/1081 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| C8A | ART1 | 0.76292 | 4 | 0 | 4 |
| C8A | NCR1 | 0.751783 | 4 | 0 | 4 |
| C8A | CACNB1 | 0.74185 | 6 | 0 | 6 |
| C8A | SLC28A2 | 0.738416 | 4 | 0 | 4 |
| C8A | HS6ST1 | 0.731235 | 3 | 0 | 3 |
| C8A | PHLDB1 | 0.729297 | 5 | 0 | 4 |
| C8A | CXCR6 | 0.726993 | 3 | 0 | 3 |
| C8A | BCAN | 0.725982 | 7 | 0 | 7 |
| C8A | UBE2D4 | 0.725055 | 3 | 0 | 3 |
| C8A | MUC8 | 0.724811 | 4 | 0 | 4 |
| C8A | HRC | 0.722334 | 3 | 0 | 3 |
| C8A | C6 | 0.715173 | 3 | 0 | 3 |
| C8A | IFNA17 | 0.714976 | 4 | 0 | 4 |
| C8A | OR6A2 | 0.714565 | 5 | 0 | 5 |
| C8A | ACR | 0.713974 | 4 | 0 | 4 |
| C8A | GP1BA | 0.713798 | 4 | 0 | 4 |
| C8A | IFNA10 | 0.708259 | 5 | 0 | 5 |
| C8A | JAK3 | 0.707576 | 5 | 0 | 5 |
| C8A | KHDRBS2 | 0.706845 | 5 | 0 | 5 |
| C8A | TUBB4A | 0.704045 | 4 | 0 | 4 |
For details and further investigation, click here
