| Full name: amyloid beta precursor protein binding family A member 2 | Alias Symbol: D15S1518E|LIN-10|MGC:14091|HsT16821 | ||
| Type: protein-coding gene | Cytoband: 15q13.1 | ||
| Entrez ID: 321 | HGNC ID: HGNC:579 | Ensembl Gene: ENSG00000034053 | OMIM ID: 602712 |
| Drug and gene relationship at DGIdb | |||
Expression of APBA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APBA2 | 321 | 209870_s_at | 0.7132 | 0.0598 | |
| GSE20347 | APBA2 | 321 | 209870_s_at | 0.5106 | 0.0000 | |
| GSE23400 | APBA2 | 321 | 209870_s_at | 0.3250 | 0.0000 | |
| GSE26886 | APBA2 | 321 | 209870_s_at | 0.7971 | 0.0000 | |
| GSE29001 | APBA2 | 321 | 209870_s_at | 0.4716 | 0.0580 | |
| GSE38129 | APBA2 | 321 | 209870_s_at | 0.4803 | 0.0000 | |
| GSE45670 | APBA2 | 321 | 209870_s_at | 0.3449 | 0.0286 | |
| GSE53622 | APBA2 | 321 | 39195 | 0.2238 | 0.1411 | |
| GSE53624 | APBA2 | 321 | 39195 | 0.2483 | 0.0191 | |
| GSE63941 | APBA2 | 321 | 209870_s_at | -0.3680 | 0.4332 | |
| GSE77861 | APBA2 | 321 | 209871_s_at | 0.1258 | 0.2829 | |
| GSE97050 | APBA2 | 321 | A_23_P146849 | -0.1383 | 0.5508 | |
| SRP007169 | APBA2 | 321 | RNAseq | 3.9221 | 0.0001 | |
| SRP064894 | APBA2 | 321 | RNAseq | 0.7954 | 0.0077 | |
| SRP133303 | APBA2 | 321 | RNAseq | 0.9953 | 0.0057 | |
| SRP159526 | APBA2 | 321 | RNAseq | 1.3462 | 0.0024 | |
| SRP193095 | APBA2 | 321 | RNAseq | 2.5062 | 0.0000 | |
| SRP219564 | APBA2 | 321 | RNAseq | 0.2426 | 0.6743 | |
| TCGA | APBA2 | 321 | RNAseq | 0.5560 | 0.0005 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by APBA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APBA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APBA2 | 321 | 2 | 8 | 20 | |
| GSE20123 | APBA2 | 321 | 2 | 8 | 20 | |
| GSE43470 | APBA2 | 321 | 4 | 5 | 34 | |
| GSE46452 | APBA2 | 321 | 3 | 7 | 49 | |
| GSE47630 | APBA2 | 321 | 8 | 11 | 21 | |
| GSE54993 | APBA2 | 321 | 4 | 6 | 60 | |
| GSE54994 | APBA2 | 321 | 6 | 7 | 40 | |
| GSE60625 | APBA2 | 321 | 4 | 0 | 7 | |
| GSE74703 | APBA2 | 321 | 4 | 3 | 29 | |
| GSE74704 | APBA2 | 321 | 1 | 6 | 13 | |
| TCGA | APBA2 | 321 | 16 | 16 | 64 |
Total number of gains: 54; Total number of losses: 77; Total Number of normals: 357.
Somatic mutations of APBA2:
Generating mutation plots.
Highly correlated genes for APBA2:
Showing top 20/370 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APBA2 | ANKLE1 | 0.763014 | 3 | 0 | 3 |
| APBA2 | LRFN1 | 0.75765 | 3 | 0 | 3 |
| APBA2 | PRR18 | 0.751303 | 3 | 0 | 3 |
| APBA2 | UPB1 | 0.740995 | 3 | 0 | 3 |
| APBA2 | PRMT3 | 0.735427 | 3 | 0 | 3 |
| APBA2 | BMF | 0.732391 | 4 | 0 | 3 |
| APBA2 | TNFAIP8L1 | 0.718625 | 4 | 0 | 4 |
| APBA2 | KRTAP4-1 | 0.708896 | 4 | 0 | 3 |
| APBA2 | CORT | 0.700122 | 3 | 0 | 3 |
| APBA2 | BMPR1B | 0.698749 | 3 | 0 | 3 |
| APBA2 | SYCP2L | 0.691587 | 3 | 0 | 3 |
| APBA2 | PRRG3 | 0.68825 | 3 | 0 | 3 |
| APBA2 | PAX6 | 0.686915 | 6 | 0 | 5 |
| APBA2 | SLC34A1 | 0.685983 | 3 | 0 | 3 |
| APBA2 | SLC39A5 | 0.685763 | 3 | 0 | 3 |
| APBA2 | GPRIN1 | 0.685105 | 3 | 0 | 3 |
| APBA2 | BARX1 | 0.681271 | 3 | 0 | 3 |
| APBA2 | HAGLROS | 0.681193 | 4 | 0 | 4 |
| APBA2 | SLC29A4 | 0.679265 | 3 | 0 | 3 |
| APBA2 | TBC1D7 | 0.675413 | 3 | 0 | 3 |
For details and further investigation, click here
