| Full name: TBC1 domain family member 7 | Alias Symbol: dJ257A7.3|FLJ32666 | ||
| Type: protein-coding gene | Cytoband: 6p24.1 | ||
| Entrez ID: 51256 | HGNC ID: HGNC:21066 | Ensembl Gene: ENSG00000145979 | OMIM ID: 612655 |
| Drug and gene relationship at DGIdb | |||
TBC1D7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04150 | mTOR signaling pathway | |
| hsa04150 | mTOR signaling pathway |
Expression of TBC1D7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TBC1D7 | 51256 | 223461_at | 0.8541 | 0.1352 | |
| GSE26886 | TBC1D7 | 51256 | 223461_at | -0.0452 | 0.8863 | |
| GSE45670 | TBC1D7 | 51256 | 223461_at | 0.3566 | 0.0244 | |
| GSE53622 | TBC1D7 | 51256 | 96482 | 0.4316 | 0.0000 | |
| GSE53624 | TBC1D7 | 51256 | 96482 | 0.3668 | 0.0000 | |
| GSE63941 | TBC1D7 | 51256 | 223461_at | -0.1186 | 0.8320 | |
| GSE77861 | TBC1D7 | 51256 | 223461_at | 0.3165 | 0.2845 | |
| GSE97050 | TBC1D7 | 51256 | A_23_P111273 | 0.4450 | 0.1936 | |
| SRP007169 | TBC1D7 | 51256 | RNAseq | 0.1707 | 0.7189 | |
| SRP064894 | TBC1D7 | 51256 | RNAseq | 0.8052 | 0.0037 | |
| SRP133303 | TBC1D7 | 51256 | RNAseq | 0.6620 | 0.0000 | |
| SRP159526 | TBC1D7 | 51256 | RNAseq | 0.6229 | 0.0697 | |
| SRP193095 | TBC1D7 | 51256 | RNAseq | 0.0425 | 0.7141 | |
| SRP219564 | TBC1D7 | 51256 | RNAseq | 0.5119 | 0.0627 | |
| TCGA | TBC1D7 | 51256 | RNAseq | 0.3693 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TBC1D7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TBC1D7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TBC1D7 | 51256 | 3 | 7 | 20 | |
| GSE20123 | TBC1D7 | 51256 | 3 | 7 | 20 | |
| GSE43470 | TBC1D7 | 51256 | 8 | 0 | 35 | |
| GSE46452 | TBC1D7 | 51256 | 1 | 10 | 48 | |
| GSE47630 | TBC1D7 | 51256 | 7 | 8 | 25 | |
| GSE54993 | TBC1D7 | 51256 | 1 | 1 | 68 | |
| GSE54994 | TBC1D7 | 51256 | 10 | 3 | 40 | |
| GSE60625 | TBC1D7 | 51256 | 0 | 1 | 10 | |
| GSE74703 | TBC1D7 | 51256 | 7 | 0 | 29 | |
| GSE74704 | TBC1D7 | 51256 | 2 | 3 | 15 | |
| TCGA | TBC1D7 | 51256 | 16 | 26 | 54 |
Total number of gains: 58; Total number of losses: 66; Total Number of normals: 364.
Somatic mutations of TBC1D7:
Generating mutation plots.
Highly correlated genes for TBC1D7:
Showing top 20/137 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TBC1D7 | CHP2 | 0.759362 | 3 | 0 | 3 |
| TBC1D7 | CCDC34 | 0.729521 | 5 | 0 | 5 |
| TBC1D7 | MAD2L1 | 0.719099 | 4 | 0 | 4 |
| TBC1D7 | UBE2I | 0.695558 | 4 | 0 | 3 |
| TBC1D7 | IRAK1 | 0.695112 | 4 | 0 | 3 |
| TBC1D7 | ZNF77 | 0.694465 | 3 | 0 | 3 |
| TBC1D7 | ZNF526 | 0.692396 | 3 | 0 | 3 |
| TBC1D7 | MCM5 | 0.686112 | 3 | 0 | 3 |
| TBC1D7 | APBA2 | 0.675413 | 3 | 0 | 3 |
| TBC1D7 | SMARCB1 | 0.673444 | 4 | 0 | 3 |
| TBC1D7 | EDC3 | 0.670743 | 4 | 0 | 3 |
| TBC1D7 | GINS2 | 0.664092 | 4 | 0 | 3 |
| TBC1D7 | POLQ | 0.663152 | 5 | 0 | 4 |
| TBC1D7 | NTHL1 | 0.662836 | 4 | 0 | 3 |
| TBC1D7 | CDK5 | 0.661996 | 3 | 0 | 3 |
| TBC1D7 | EEF1E1 | 0.661305 | 4 | 0 | 3 |
| TBC1D7 | ACOT7 | 0.652994 | 3 | 0 | 3 |
| TBC1D7 | MND1 | 0.646774 | 4 | 0 | 3 |
| TBC1D7 | ALYREF | 0.645166 | 3 | 0 | 3 |
| TBC1D7 | PRPF8 | 0.645045 | 3 | 0 | 3 |
For details and further investigation, click here
