BMPR1B

 

Full name: bone morphogenetic protein receptor type 1B Alias Symbol: ALK6|CDw293
Type: protein-coding gene Cytoband: 4q22.3
Entrez ID: 658 HGNC ID: HGNC:1077 Ensembl Gene: ENSG00000138696 OMIM ID: 603248
Drug and gene relationship at DGIdb

 

BMPR1B involved pathways:

KEGG pathway Description View
hsa04350TGF-beta signaling pathway
hsa04360Axon guidance
hsa04390Hippo signaling pathway
hsa04550Signaling pathways regulating pluripotency of stem cells

 

Expression of BMPR1B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 BMPR1B 658 229975_at 0.3255 0.9200
GSE20347 BMPR1B 658 210523_at 0.2254 0.0005
GSE23400 BMPR1B 658 210523_at -0.0426 0.3756
GSE26886 BMPR1B 658 229975_at 1.9313 0.0016
GSE29001 BMPR1B 658 210523_at -0.0398 0.7438
GSE38129 BMPR1B 658 210523_at 0.0872 0.2027
GSE45670 BMPR1B 658 229975_at 0.3388 0.6373
GSE53622 BMPR1B 658 18716 0.5181 0.0005
GSE53624 BMPR1B 658 18716 0.6039 0.0000
GSE63941 BMPR1B 658 229975_at -0.3497 0.8331
GSE77861 BMPR1B 658 229975_at 0.2621 0.2889
GSE97050 BMPR1B 658 A_24_P63380 -0.2224 0.7653
SRP007169 BMPR1B 658 RNAseq 6.3155 0.0000
SRP064894 BMPR1B 658 RNAseq 2.1965 0.0000
SRP133303 BMPR1B 658 RNAseq 1.2975 0.0100
SRP159526 BMPR1B 658 RNAseq 2.1408 0.0084
SRP219564 BMPR1B 658 RNAseq 1.9306 0.1051
TCGA BMPR1B 658 RNAseq -0.5873 0.0474

Upregulated datasets: 5; Downregulated datasets: 0.  

 

Survival by BMPR1B expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of BMPR1B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 BMPR1B 658 0 12 18
GSE20123 BMPR1B 658 0 12 18
GSE43470 BMPR1B 658 0 15 28
GSE46452 BMPR1B 658 1 36 22
GSE47630 BMPR1B 658 0 20 20
GSE54993 BMPR1B 658 8 0 62
GSE54994 BMPR1B 658 1 11 41
GSE60625 BMPR1B 658 0 3 8
GSE74703 BMPR1B 658 0 13 23
GSE74704 BMPR1B 658 0 6 14
TCGA BMPR1B 658 8 40 48

Total number of gains: 18; Total number of losses: 168; Total Number of normals: 302.  

 

Somatic mutations of BMPR1B:

 

Generating mutation plots.

 

Highly correlated genes for BMPR1B:

 

Showing top 20/269 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
BMPR1BLAMA20.793911303
BMPR1BAPBA20.698749303
BMPR1BLENG10.687662303
BMPR1BBRF20.682369303
BMPR1BART40.677145403
BMPR1BALAS20.666778303
BMPR1BARL30.664805303
BMPR1BGPM6A0.663106403
BMPR1BGTF2IRD2B0.659642303
BMPR1BTIGD70.659449303
BMPR1BCHGB0.649887403
BMPR1BDDIT4L0.649063303
BMPR1BCEP720.647301303
BMPR1BLINC012780.647016303
BMPR1BSHISA40.645143303
BMPR1BXRCC20.644822404
BMPR1BRANBP30.643388403
BMPR1BALDH8A10.641742303
BMPR1BZNF1600.63926303
BMPR1BGCM20.638811303

For details and further investigation, click here