| Full name: APC regulator of WNT signaling pathway 2 | Alias Symbol: APCL | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 10297 | HGNC ID: HGNC:24036 | Ensembl Gene: ENSG00000115266 | OMIM ID: 612034 |
| Drug and gene relationship at DGIdb | |||
APC2 involved pathways:
Expression of APC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APC2 | 10297 | 205320_at | 0.1097 | 0.6557 | |
| GSE20347 | APC2 | 10297 | 205320_at | 0.0611 | 0.3599 | |
| GSE23400 | APC2 | 10297 | 205320_at | -0.1303 | 0.0006 | |
| GSE26886 | APC2 | 10297 | 205320_at | 0.2700 | 0.1262 | |
| GSE29001 | APC2 | 10297 | 205320_at | 0.0269 | 0.8913 | |
| GSE38129 | APC2 | 10297 | 205320_at | -0.1414 | 0.0367 | |
| GSE45670 | APC2 | 10297 | 205320_at | -0.0934 | 0.2547 | |
| GSE53622 | APC2 | 10297 | 64142 | -0.0429 | 0.6899 | |
| GSE53624 | APC2 | 10297 | 64142 | -0.2775 | 0.0043 | |
| GSE63941 | APC2 | 10297 | 205320_at | 0.2928 | 0.0518 | |
| GSE77861 | APC2 | 10297 | 205320_at | -0.1207 | 0.3038 | |
| GSE97050 | APC2 | 10297 | A_23_P101905 | -0.0013 | 0.9970 | |
| SRP064894 | APC2 | 10297 | RNAseq | 0.8038 | 0.0051 | |
| SRP133303 | APC2 | 10297 | RNAseq | 0.2863 | 0.1663 | |
| SRP159526 | APC2 | 10297 | RNAseq | 0.2292 | 0.5283 | |
| SRP193095 | APC2 | 10297 | RNAseq | 0.3457 | 0.0303 | |
| SRP219564 | APC2 | 10297 | RNAseq | 0.0894 | 0.8039 | |
| TCGA | APC2 | 10297 | RNAseq | -0.5199 | 0.0082 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by APC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APC2 | 10297 | 4 | 6 | 20 | |
| GSE20123 | APC2 | 10297 | 4 | 5 | 21 | |
| GSE43470 | APC2 | 10297 | 1 | 11 | 31 | |
| GSE46452 | APC2 | 10297 | 47 | 1 | 11 | |
| GSE47630 | APC2 | 10297 | 5 | 7 | 28 | |
| GSE54993 | APC2 | 10297 | 16 | 3 | 51 | |
| GSE54994 | APC2 | 10297 | 8 | 15 | 30 | |
| GSE60625 | APC2 | 10297 | 9 | 0 | 2 | |
| GSE74703 | APC2 | 10297 | 1 | 8 | 27 | |
| GSE74704 | APC2 | 10297 | 3 | 3 | 14 | |
| TCGA | APC2 | 10297 | 6 | 25 | 65 |
Total number of gains: 104; Total number of losses: 84; Total Number of normals: 300.
Somatic mutations of APC2:
Generating mutation plots.
Highly correlated genes for APC2:
Showing top 20/716 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APC2 | ASB11 | 0.779995 | 3 | 0 | 3 |
| APC2 | STK32A | 0.732972 | 3 | 0 | 3 |
| APC2 | NPTXR | 0.712121 | 6 | 0 | 6 |
| APC2 | KCNF1 | 0.702093 | 5 | 0 | 5 |
| APC2 | LINC00608 | 0.700139 | 3 | 0 | 3 |
| APC2 | ZDHHC1 | 0.690447 | 3 | 0 | 3 |
| APC2 | SARDH | 0.689946 | 5 | 0 | 5 |
| APC2 | ISLR2 | 0.68978 | 3 | 0 | 3 |
| APC2 | REG3G | 0.684099 | 3 | 0 | 3 |
| APC2 | DENND6B | 0.681657 | 5 | 0 | 5 |
| APC2 | DPP10-AS1 | 0.673512 | 3 | 0 | 3 |
| APC2 | HPCA | 0.671094 | 4 | 0 | 4 |
| APC2 | PTMS | 0.668839 | 5 | 0 | 4 |
| APC2 | CORO6 | 0.664289 | 3 | 0 | 3 |
| APC2 | LINC00311 | 0.662717 | 4 | 0 | 3 |
| APC2 | IGH | 0.662402 | 7 | 0 | 6 |
| APC2 | ARVCF | 0.661542 | 5 | 0 | 5 |
| APC2 | CLDN9 | 0.660732 | 5 | 0 | 4 |
| APC2 | EBF4 | 0.65898 | 4 | 0 | 3 |
| APC2 | NMUR1 | 0.65813 | 7 | 0 | 5 |
For details and further investigation, click here
