| Full name: transmembrane protein 53 | Alias Symbol: FLJ22353|NET4 | ||
| Type: protein-coding gene | Cytoband: 1p34.1 | ||
| Entrez ID: 79639 | HGNC ID: HGNC:26186 | Ensembl Gene: ENSG00000126106 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of TMEM53:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMEM53 | 79639 | 219462_at | 0.0401 | 0.9135 | |
| GSE20347 | TMEM53 | 79639 | 219462_at | -0.0263 | 0.8194 | |
| GSE23400 | TMEM53 | 79639 | 219462_at | -0.0984 | 0.0090 | |
| GSE26886 | TMEM53 | 79639 | 219462_at | -0.1655 | 0.3648 | |
| GSE29001 | TMEM53 | 79639 | 219462_at | -0.0656 | 0.6939 | |
| GSE38129 | TMEM53 | 79639 | 219462_at | -0.0385 | 0.7475 | |
| GSE45670 | TMEM53 | 79639 | 219462_at | 0.1963 | 0.0406 | |
| GSE53622 | TMEM53 | 79639 | 14184 | -0.3986 | 0.0000 | |
| GSE53624 | TMEM53 | 79639 | 14184 | -0.4611 | 0.0000 | |
| GSE63941 | TMEM53 | 79639 | 219462_at | -0.1558 | 0.7313 | |
| GSE77861 | TMEM53 | 79639 | 219462_at | -0.0395 | 0.7725 | |
| GSE97050 | TMEM53 | 79639 | A_33_P3332396 | -0.6925 | 0.0898 | |
| SRP007169 | TMEM53 | 79639 | RNAseq | 0.0336 | 0.9498 | |
| SRP064894 | TMEM53 | 79639 | RNAseq | 0.8048 | 0.0089 | |
| SRP133303 | TMEM53 | 79639 | RNAseq | -0.2180 | 0.2107 | |
| SRP159526 | TMEM53 | 79639 | RNAseq | 0.3643 | 0.3041 | |
| SRP193095 | TMEM53 | 79639 | RNAseq | -0.1948 | 0.1446 | |
| SRP219564 | TMEM53 | 79639 | RNAseq | 0.5941 | 0.0305 | |
| TCGA | TMEM53 | 79639 | RNAseq | -0.1236 | 0.0882 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TMEM53 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMEM53:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMEM53 | 79639 | 4 | 3 | 23 | |
| GSE20123 | TMEM53 | 79639 | 4 | 2 | 24 | |
| GSE43470 | TMEM53 | 79639 | 7 | 2 | 34 | |
| GSE46452 | TMEM53 | 79639 | 2 | 1 | 56 | |
| GSE47630 | TMEM53 | 79639 | 9 | 3 | 28 | |
| GSE54993 | TMEM53 | 79639 | 0 | 1 | 69 | |
| GSE54994 | TMEM53 | 79639 | 13 | 2 | 38 | |
| GSE60625 | TMEM53 | 79639 | 0 | 0 | 11 | |
| GSE74703 | TMEM53 | 79639 | 6 | 1 | 29 | |
| GSE74704 | TMEM53 | 79639 | 2 | 0 | 18 | |
| TCGA | TMEM53 | 79639 | 13 | 17 | 66 |
Total number of gains: 60; Total number of losses: 32; Total Number of normals: 396.
Somatic mutations of TMEM53:
Generating mutation plots.
Highly correlated genes for TMEM53:
Showing top 20/289 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMEM53 | ACSS2 | 0.825038 | 3 | 0 | 3 |
| TMEM53 | ADAD2 | 0.806292 | 5 | 0 | 5 |
| TMEM53 | CCNB3 | 0.796355 | 4 | 0 | 4 |
| TMEM53 | CCDC88C | 0.794314 | 3 | 0 | 3 |
| TMEM53 | SFTPA2 | 0.768013 | 3 | 0 | 3 |
| TMEM53 | HCCS | 0.747715 | 3 | 0 | 3 |
| TMEM53 | IP6K1 | 0.72341 | 4 | 0 | 4 |
| TMEM53 | ARAF | 0.722095 | 3 | 0 | 3 |
| TMEM53 | KRTAP21-2 | 0.720488 | 3 | 0 | 3 |
| TMEM53 | ZACN | 0.715723 | 3 | 0 | 3 |
| TMEM53 | MED22 | 0.70815 | 3 | 0 | 3 |
| TMEM53 | PCNT | 0.708056 | 3 | 0 | 3 |
| TMEM53 | RIMKLA | 0.707592 | 3 | 0 | 3 |
| TMEM53 | ESR2 | 0.691164 | 3 | 0 | 3 |
| TMEM53 | NUCB1 | 0.688805 | 3 | 0 | 3 |
| TMEM53 | ZNF676 | 0.682871 | 3 | 0 | 3 |
| TMEM53 | ALDOC | 0.681878 | 3 | 0 | 3 |
| TMEM53 | UTY | 0.681149 | 3 | 0 | 3 |
| TMEM53 | KRTAP19-2 | 0.680791 | 3 | 0 | 3 |
| TMEM53 | HIC2 | 0.680287 | 5 | 0 | 4 |
For details and further investigation, click here
