| Full name: eukaryotic elongation factor, selenocysteine-tRNA specific | Alias Symbol: SELB|EFSEC|eEFSec | ||
| Type: protein-coding gene | Cytoband: 3q21.3 | ||
| Entrez ID: 60678 | HGNC ID: HGNC:24614 | Ensembl Gene: ENSG00000132394 | OMIM ID: 607695 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of EEFSEC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EEFSEC | 60678 | 227540_at | 0.1429 | 0.6711 | |
| GSE26886 | EEFSEC | 60678 | 227540_at | 0.3368 | 0.0304 | |
| GSE45670 | EEFSEC | 60678 | 227540_at | 0.2320 | 0.0096 | |
| GSE53622 | EEFSEC | 60678 | 27678 | 0.5367 | 0.0000 | |
| GSE53624 | EEFSEC | 60678 | 27678 | 0.7150 | 0.0000 | |
| GSE63941 | EEFSEC | 60678 | 227540_at | 1.7981 | 0.0002 | |
| GSE77861 | EEFSEC | 60678 | 227540_at | 0.1440 | 0.5082 | |
| GSE97050 | EEFSEC | 60678 | A_23_P144202 | 0.4446 | 0.2018 | |
| SRP007169 | EEFSEC | 60678 | RNAseq | 0.1491 | 0.7121 | |
| SRP008496 | EEFSEC | 60678 | RNAseq | 0.3573 | 0.2679 | |
| SRP064894 | EEFSEC | 60678 | RNAseq | 1.0675 | 0.0003 | |
| SRP133303 | EEFSEC | 60678 | RNAseq | 0.6272 | 0.0042 | |
| SRP159526 | EEFSEC | 60678 | RNAseq | 0.5130 | 0.0281 | |
| SRP193095 | EEFSEC | 60678 | RNAseq | 0.5792 | 0.0000 | |
| SRP219564 | EEFSEC | 60678 | RNAseq | 0.6651 | 0.0439 | |
| TCGA | EEFSEC | 60678 | RNAseq | 0.1835 | 0.0010 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by EEFSEC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EEFSEC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EEFSEC | 60678 | 17 | 0 | 13 | |
| GSE20123 | EEFSEC | 60678 | 17 | 0 | 13 | |
| GSE43470 | EEFSEC | 60678 | 19 | 0 | 24 | |
| GSE46452 | EEFSEC | 60678 | 14 | 5 | 40 | |
| GSE47630 | EEFSEC | 60678 | 18 | 3 | 19 | |
| GSE54993 | EEFSEC | 60678 | 2 | 7 | 61 | |
| GSE54994 | EEFSEC | 60678 | 31 | 3 | 19 | |
| GSE60625 | EEFSEC | 60678 | 0 | 6 | 5 | |
| GSE74703 | EEFSEC | 60678 | 17 | 0 | 19 | |
| GSE74704 | EEFSEC | 60678 | 13 | 0 | 7 | |
| TCGA | EEFSEC | 60678 | 57 | 5 | 34 |
Total number of gains: 205; Total number of losses: 29; Total Number of normals: 254.
Somatic mutations of EEFSEC:
Generating mutation plots.
Highly correlated genes for EEFSEC:
Showing top 20/874 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EEFSEC | WTAP | 0.807176 | 3 | 0 | 3 |
| EEFSEC | NOTCH3 | 0.78369 | 3 | 0 | 3 |
| EEFSEC | TBCC | 0.772371 | 3 | 0 | 3 |
| EEFSEC | SYNGR2 | 0.751278 | 4 | 0 | 4 |
| EEFSEC | DCXR | 0.744109 | 3 | 0 | 3 |
| EEFSEC | GNA13 | 0.743811 | 3 | 0 | 3 |
| EEFSEC | C5orf22 | 0.737404 | 3 | 0 | 3 |
| EEFSEC | ARAF | 0.728931 | 5 | 0 | 4 |
| EEFSEC | POLDIP2 | 0.728597 | 3 | 0 | 3 |
| EEFSEC | GATA1 | 0.727976 | 3 | 0 | 3 |
| EEFSEC | PACS1 | 0.72597 | 3 | 0 | 3 |
| EEFSEC | KEAP1 | 0.725611 | 3 | 0 | 3 |
| EEFSEC | B9D2 | 0.724381 | 3 | 0 | 3 |
| EEFSEC | MCTP1 | 0.722166 | 3 | 0 | 3 |
| EEFSEC | DDX10 | 0.72177 | 3 | 0 | 3 |
| EEFSEC | UBB | 0.720965 | 3 | 0 | 3 |
| EEFSEC | STRN4 | 0.72065 | 3 | 0 | 3 |
| EEFSEC | CNOT1 | 0.720523 | 3 | 0 | 3 |
| EEFSEC | HAUS6 | 0.719456 | 3 | 0 | 3 |
| EEFSEC | MRPL38 | 0.718913 | 5 | 0 | 4 |
For details and further investigation, click here
