| Full name: ADP ribosylation factor GTPase activating protein 2 | Alias Symbol: IRZ|Zfp289|FLJ14576 | ||
| Type: protein-coding gene | Cytoband: 11p11.2 | ||
| Entrez ID: 84364 | HGNC ID: HGNC:13504 | Ensembl Gene: ENSG00000149182 | OMIM ID: 606908 |
| Drug and gene relationship at DGIdb | |||
Expression of ARFGAP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARFGAP2 | 84364 | 211975_at | 0.2439 | 0.6617 | |
| GSE20347 | ARFGAP2 | 84364 | 211975_at | -0.3904 | 0.0014 | |
| GSE23400 | ARFGAP2 | 84364 | 211975_at | -0.1698 | 0.0130 | |
| GSE26886 | ARFGAP2 | 84364 | 211975_at | -1.1064 | 0.0001 | |
| GSE29001 | ARFGAP2 | 84364 | 211975_at | -0.3184 | 0.2330 | |
| GSE38129 | ARFGAP2 | 84364 | 211975_at | -0.3464 | 0.0000 | |
| GSE45670 | ARFGAP2 | 84364 | 211975_at | 0.0498 | 0.7617 | |
| GSE63941 | ARFGAP2 | 84364 | 211975_at | 0.8190 | 0.0575 | |
| GSE77861 | ARFGAP2 | 84364 | 211975_at | -0.0385 | 0.8953 | |
| GSE97050 | ARFGAP2 | 84364 | A_33_P3272483 | -0.1305 | 0.5828 | |
| SRP007169 | ARFGAP2 | 84364 | RNAseq | -1.1805 | 0.0062 | |
| SRP008496 | ARFGAP2 | 84364 | RNAseq | -1.0590 | 0.0000 | |
| SRP064894 | ARFGAP2 | 84364 | RNAseq | -0.0553 | 0.7172 | |
| SRP133303 | ARFGAP2 | 84364 | RNAseq | -0.4470 | 0.0001 | |
| SRP159526 | ARFGAP2 | 84364 | RNAseq | -0.4522 | 0.0554 | |
| SRP193095 | ARFGAP2 | 84364 | RNAseq | -0.4306 | 0.0000 | |
| SRP219564 | ARFGAP2 | 84364 | RNAseq | -0.1473 | 0.6027 | |
| TCGA | ARFGAP2 | 84364 | RNAseq | -0.0861 | 0.0540 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by ARFGAP2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ARFGAP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARFGAP2 | 84364 | 3 | 7 | 20 | |
| GSE20123 | ARFGAP2 | 84364 | 3 | 6 | 21 | |
| GSE43470 | ARFGAP2 | 84364 | 1 | 4 | 38 | |
| GSE46452 | ARFGAP2 | 84364 | 8 | 5 | 46 | |
| GSE47630 | ARFGAP2 | 84364 | 3 | 9 | 28 | |
| GSE54993 | ARFGAP2 | 84364 | 3 | 0 | 67 | |
| GSE54994 | ARFGAP2 | 84364 | 1 | 11 | 41 | |
| GSE60625 | ARFGAP2 | 84364 | 0 | 0 | 11 | |
| GSE74703 | ARFGAP2 | 84364 | 1 | 2 | 33 | |
| GSE74704 | ARFGAP2 | 84364 | 2 | 4 | 14 | |
| TCGA | ARFGAP2 | 84364 | 10 | 19 | 67 |
Total number of gains: 35; Total number of losses: 67; Total Number of normals: 386.
Somatic mutations of ARFGAP2:
Generating mutation plots.
Highly correlated genes for ARFGAP2:
Showing top 20/409 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARFGAP2 | DMAP1 | 0.840286 | 3 | 0 | 3 |
| ARFGAP2 | ABHD16A | 0.837267 | 3 | 0 | 3 |
| ARFGAP2 | STK38 | 0.835473 | 3 | 0 | 3 |
| ARFGAP2 | YTHDF2 | 0.81096 | 3 | 0 | 3 |
| ARFGAP2 | KDM3B | 0.805188 | 3 | 0 | 3 |
| ARFGAP2 | SLC35B3 | 0.801329 | 3 | 0 | 3 |
| ARFGAP2 | MCOLN1 | 0.798628 | 3 | 0 | 3 |
| ARFGAP2 | SF1 | 0.783043 | 3 | 0 | 3 |
| ARFGAP2 | PLEKHF2 | 0.781304 | 3 | 0 | 3 |
| ARFGAP2 | CRNKL1 | 0.780235 | 3 | 0 | 3 |
| ARFGAP2 | ZNF564 | 0.775005 | 3 | 0 | 3 |
| ARFGAP2 | USP20 | 0.773786 | 3 | 0 | 3 |
| ARFGAP2 | ITPRIPL2 | 0.76901 | 3 | 0 | 3 |
| ARFGAP2 | NAA20 | 0.767374 | 3 | 0 | 3 |
| ARFGAP2 | FEM1A | 0.761436 | 3 | 0 | 3 |
| ARFGAP2 | ZNF416 | 0.753113 | 3 | 0 | 3 |
| ARFGAP2 | TRAPPC8 | 0.751628 | 3 | 0 | 3 |
| ARFGAP2 | FBXL14 | 0.749852 | 3 | 0 | 3 |
| ARFGAP2 | LSM14A | 0.747423 | 3 | 0 | 3 |
| ARFGAP2 | CPEB4 | 0.7464 | 3 | 0 | 3 |
For details and further investigation, click here
