| Full name: pleckstrin homology and FYVE domain containing 2 | Alias Symbol: ZFYVE18|PHAFIN2|FLJ13187 | ||
| Type: protein-coding gene | Cytoband: 8q22.1 | ||
| Entrez ID: 79666 | HGNC ID: HGNC:20757 | Ensembl Gene: ENSG00000175895 | OMIM ID: 615208 |
| Drug and gene relationship at DGIdb | |||
Expression of PLEKHF2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLEKHF2 | 79666 | 218640_s_at | 0.0626 | 0.9072 | |
| GSE20347 | PLEKHF2 | 79666 | 218640_s_at | -0.4029 | 0.0743 | |
| GSE23400 | PLEKHF2 | 79666 | 218640_s_at | 0.2074 | 0.0059 | |
| GSE26886 | PLEKHF2 | 79666 | 218640_s_at | -0.8721 | 0.0169 | |
| GSE29001 | PLEKHF2 | 79666 | 218640_s_at | 0.0538 | 0.8997 | |
| GSE38129 | PLEKHF2 | 79666 | 218640_s_at | -0.2742 | 0.1345 | |
| GSE45670 | PLEKHF2 | 79666 | 218640_s_at | 0.0992 | 0.5487 | |
| GSE53622 | PLEKHF2 | 79666 | 61531 | -0.0484 | 0.5992 | |
| GSE53624 | PLEKHF2 | 79666 | 61531 | -0.2115 | 0.0009 | |
| GSE63941 | PLEKHF2 | 79666 | 218640_s_at | 0.9582 | 0.0636 | |
| GSE77861 | PLEKHF2 | 79666 | 218640_s_at | -0.3018 | 0.2263 | |
| GSE97050 | PLEKHF2 | 79666 | A_23_P20275 | -0.1479 | 0.4797 | |
| SRP007169 | PLEKHF2 | 79666 | RNAseq | -1.0782 | 0.0071 | |
| SRP008496 | PLEKHF2 | 79666 | RNAseq | -0.7186 | 0.0005 | |
| SRP064894 | PLEKHF2 | 79666 | RNAseq | -0.0150 | 0.9398 | |
| SRP133303 | PLEKHF2 | 79666 | RNAseq | -0.0301 | 0.8747 | |
| SRP159526 | PLEKHF2 | 79666 | RNAseq | -0.3930 | 0.2832 | |
| SRP193095 | PLEKHF2 | 79666 | RNAseq | -0.4504 | 0.0002 | |
| SRP219564 | PLEKHF2 | 79666 | RNAseq | -0.0970 | 0.7284 | |
| TCGA | PLEKHF2 | 79666 | RNAseq | -0.0660 | 0.2217 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PLEKHF2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLEKHF2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLEKHF2 | 79666 | 16 | 0 | 14 | |
| GSE20123 | PLEKHF2 | 79666 | 17 | 0 | 13 | |
| GSE43470 | PLEKHF2 | 79666 | 21 | 1 | 21 | |
| GSE46452 | PLEKHF2 | 79666 | 23 | 0 | 36 | |
| GSE47630 | PLEKHF2 | 79666 | 24 | 0 | 16 | |
| GSE54993 | PLEKHF2 | 79666 | 0 | 20 | 50 | |
| GSE54994 | PLEKHF2 | 79666 | 34 | 1 | 18 | |
| GSE60625 | PLEKHF2 | 79666 | 0 | 4 | 7 | |
| GSE74703 | PLEKHF2 | 79666 | 18 | 1 | 17 | |
| GSE74704 | PLEKHF2 | 79666 | 12 | 0 | 8 | |
| TCGA | PLEKHF2 | 79666 | 56 | 1 | 39 |
Total number of gains: 221; Total number of losses: 28; Total Number of normals: 239.
Somatic mutations of PLEKHF2:
Generating mutation plots.
Highly correlated genes for PLEKHF2:
Showing top 20/553 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLEKHF2 | RNF146 | 0.801736 | 3 | 0 | 3 |
| PLEKHF2 | ZNF564 | 0.798418 | 4 | 0 | 4 |
| PLEKHF2 | ANGEL2 | 0.791876 | 3 | 0 | 3 |
| PLEKHF2 | EXOC2 | 0.782514 | 3 | 0 | 3 |
| PLEKHF2 | ARFGAP2 | 0.781304 | 3 | 0 | 3 |
| PLEKHF2 | ZNF41 | 0.777738 | 3 | 0 | 3 |
| PLEKHF2 | RALGPS2 | 0.774537 | 3 | 0 | 3 |
| PLEKHF2 | UGP2 | 0.769893 | 4 | 0 | 4 |
| PLEKHF2 | DNAJB14 | 0.765478 | 3 | 0 | 3 |
| PLEKHF2 | DLD | 0.764301 | 4 | 0 | 4 |
| PLEKHF2 | PURA | 0.759975 | 3 | 0 | 3 |
| PLEKHF2 | EIF4ENIF1 | 0.759948 | 3 | 0 | 3 |
| PLEKHF2 | HEATR5B | 0.75755 | 3 | 0 | 3 |
| PLEKHF2 | ZFP3 | 0.753949 | 3 | 0 | 3 |
| PLEKHF2 | PRKAB1 | 0.753401 | 3 | 0 | 3 |
| PLEKHF2 | ZSCAN12 | 0.742978 | 3 | 0 | 3 |
| PLEKHF2 | TMEM181 | 0.741723 | 3 | 0 | 3 |
| PLEKHF2 | TMEM161B | 0.740986 | 3 | 0 | 3 |
| PLEKHF2 | GPBP1 | 0.736309 | 3 | 0 | 3 |
| PLEKHF2 | TANC1 | 0.731089 | 3 | 0 | 3 |
For details and further investigation, click here
