| Full name: mucolipin 1 | Alias Symbol: TRPML1|ML4|MLIV|MST080|MSTP080|TRPM-L1 | ||
| Type: protein-coding gene | Cytoband: 19p13.2 | ||
| Entrez ID: 57192 | HGNC ID: HGNC:13356 | Ensembl Gene: ENSG00000090674 | OMIM ID: 605248 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MCOLN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MCOLN1 | 57192 | 219952_s_at | 0.2446 | 0.4280 | |
| GSE20347 | MCOLN1 | 57192 | 219952_s_at | -0.1326 | 0.1855 | |
| GSE23400 | MCOLN1 | 57192 | 219952_s_at | 0.0279 | 0.5243 | |
| GSE26886 | MCOLN1 | 57192 | 219952_s_at | 0.1578 | 0.3083 | |
| GSE29001 | MCOLN1 | 57192 | 219952_s_at | -0.2137 | 0.4386 | |
| GSE38129 | MCOLN1 | 57192 | 219952_s_at | 0.0875 | 0.6606 | |
| GSE45670 | MCOLN1 | 57192 | 219952_s_at | 0.1333 | 0.4051 | |
| GSE53622 | MCOLN1 | 57192 | 102721 | 0.1351 | 0.0693 | |
| GSE53624 | MCOLN1 | 57192 | 102721 | 0.3414 | 0.0000 | |
| GSE63941 | MCOLN1 | 57192 | 219952_s_at | -0.4241 | 0.2875 | |
| GSE77861 | MCOLN1 | 57192 | 219952_s_at | -0.0372 | 0.8564 | |
| GSE97050 | MCOLN1 | 57192 | A_23_P27571 | -0.0394 | 0.8994 | |
| SRP007169 | MCOLN1 | 57192 | RNAseq | -1.2361 | 0.0089 | |
| SRP008496 | MCOLN1 | 57192 | RNAseq | -1.1508 | 0.0000 | |
| SRP064894 | MCOLN1 | 57192 | RNAseq | 0.5697 | 0.0135 | |
| SRP133303 | MCOLN1 | 57192 | RNAseq | 0.1595 | 0.3129 | |
| SRP159526 | MCOLN1 | 57192 | RNAseq | 0.2297 | 0.3588 | |
| SRP193095 | MCOLN1 | 57192 | RNAseq | -0.1214 | 0.4193 | |
| SRP219564 | MCOLN1 | 57192 | RNAseq | 0.5267 | 0.0979 | |
| TCGA | MCOLN1 | 57192 | RNAseq | 0.0346 | 0.5482 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by MCOLN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MCOLN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MCOLN1 | 57192 | 5 | 3 | 22 | |
| GSE20123 | MCOLN1 | 57192 | 4 | 2 | 24 | |
| GSE43470 | MCOLN1 | 57192 | 2 | 6 | 35 | |
| GSE46452 | MCOLN1 | 57192 | 47 | 1 | 11 | |
| GSE47630 | MCOLN1 | 57192 | 5 | 7 | 28 | |
| GSE54993 | MCOLN1 | 57192 | 16 | 3 | 51 | |
| GSE54994 | MCOLN1 | 57192 | 6 | 13 | 34 | |
| GSE60625 | MCOLN1 | 57192 | 9 | 0 | 2 | |
| GSE74703 | MCOLN1 | 57192 | 2 | 4 | 30 | |
| GSE74704 | MCOLN1 | 57192 | 1 | 2 | 17 | |
| TCGA | MCOLN1 | 57192 | 9 | 20 | 67 |
Total number of gains: 106; Total number of losses: 61; Total Number of normals: 321.
Somatic mutations of MCOLN1:
Generating mutation plots.
Highly correlated genes for MCOLN1:
Showing top 20/195 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MCOLN1 | C1orf122 | 0.818132 | 3 | 0 | 3 |
| MCOLN1 | ARPC4 | 0.815691 | 3 | 0 | 3 |
| MCOLN1 | PSMB6 | 0.804724 | 3 | 0 | 3 |
| MCOLN1 | ARFGAP2 | 0.798628 | 3 | 0 | 3 |
| MCOLN1 | KEAP1 | 0.789999 | 3 | 0 | 3 |
| MCOLN1 | ZNF668 | 0.789298 | 3 | 0 | 3 |
| MCOLN1 | USP36 | 0.767047 | 3 | 0 | 3 |
| MCOLN1 | CNNM3 | 0.760271 | 3 | 0 | 3 |
| MCOLN1 | MED26 | 0.754271 | 3 | 0 | 3 |
| MCOLN1 | COMMD7 | 0.753038 | 3 | 0 | 3 |
| MCOLN1 | MRPS18A | 0.748895 | 3 | 0 | 3 |
| MCOLN1 | UQCRFS1 | 0.748084 | 3 | 0 | 3 |
| MCOLN1 | WDR70 | 0.747534 | 3 | 0 | 3 |
| MCOLN1 | TAF15 | 0.745714 | 3 | 0 | 3 |
| MCOLN1 | FAM111A | 0.74048 | 3 | 0 | 3 |
| MCOLN1 | LSM7 | 0.731527 | 3 | 0 | 3 |
| MCOLN1 | FAM118B | 0.730636 | 3 | 0 | 3 |
| MCOLN1 | HNRNPAB | 0.723021 | 3 | 0 | 3 |
| MCOLN1 | HNRNPM | 0.719718 | 4 | 0 | 4 |
| MCOLN1 | UBE2M | 0.718417 | 5 | 0 | 5 |
For details and further investigation, click here
