| Full name: SRY-box transcription factor 12 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 20p13 | ||
| Entrez ID: 6666 | HGNC ID: HGNC:11198 | Ensembl Gene: ENSG00000177732 | OMIM ID: 601947 |
| Drug and gene relationship at DGIdb | |||
Expression of SOX12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SOX12 | 6666 | 204432_at | 0.9667 | 0.2512 | |
| GSE20347 | SOX12 | 6666 | 204432_at | 0.8487 | 0.0000 | |
| GSE23400 | SOX12 | 6666 | 204432_at | 0.3151 | 0.0000 | |
| GSE26886 | SOX12 | 6666 | 204432_at | 1.1305 | 0.0000 | |
| GSE29001 | SOX12 | 6666 | 204432_at | 0.6558 | 0.0042 | |
| GSE38129 | SOX12 | 6666 | 204432_at | 1.1063 | 0.0000 | |
| GSE45670 | SOX12 | 6666 | 204432_at | 0.7420 | 0.0058 | |
| GSE53622 | SOX12 | 6666 | 51235 | 0.4100 | 0.0000 | |
| GSE53624 | SOX12 | 6666 | 51235 | -0.0449 | 0.6769 | |
| GSE63941 | SOX12 | 6666 | 204432_at | -0.3289 | 0.5370 | |
| GSE77861 | SOX12 | 6666 | 204432_at | 0.4878 | 0.0355 | |
| GSE97050 | SOX12 | 6666 | A_24_P156267 | -0.0702 | 0.8333 | |
| SRP007169 | SOX12 | 6666 | RNAseq | 1.2068 | 0.0330 | |
| SRP064894 | SOX12 | 6666 | RNAseq | 1.2150 | 0.0000 | |
| SRP133303 | SOX12 | 6666 | RNAseq | 0.7181 | 0.0016 | |
| SRP159526 | SOX12 | 6666 | RNAseq | 1.8474 | 0.0000 | |
| SRP193095 | SOX12 | 6666 | RNAseq | 1.0097 | 0.0000 | |
| SRP219564 | SOX12 | 6666 | RNAseq | 0.9217 | 0.1016 | |
| TCGA | SOX12 | 6666 | RNAseq | 0.3170 | 0.0001 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by SOX12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SOX12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SOX12 | 6666 | 12 | 4 | 14 | |
| GSE20123 | SOX12 | 6666 | 13 | 4 | 13 | |
| GSE43470 | SOX12 | 6666 | 11 | 1 | 31 | |
| GSE46452 | SOX12 | 6666 | 26 | 1 | 32 | |
| GSE47630 | SOX12 | 6666 | 19 | 4 | 17 | |
| GSE54993 | SOX12 | 6666 | 2 | 15 | 53 | |
| GSE54994 | SOX12 | 6666 | 24 | 2 | 27 | |
| GSE60625 | SOX12 | 6666 | 0 | 0 | 11 | |
| GSE74703 | SOX12 | 6666 | 10 | 1 | 25 | |
| GSE74704 | SOX12 | 6666 | 8 | 2 | 10 | |
| TCGA | SOX12 | 6666 | 41 | 11 | 44 |
Total number of gains: 166; Total number of losses: 45; Total Number of normals: 277.
Somatic mutations of SOX12:
Generating mutation plots.
Highly correlated genes for SOX12:
Showing top 20/470 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SOX12 | ADAP1 | 0.744421 | 3 | 0 | 3 |
| SOX12 | TOX2 | 0.733813 | 3 | 0 | 3 |
| SOX12 | TMC8 | 0.724545 | 3 | 0 | 3 |
| SOX12 | ARHGEF1 | 0.709711 | 3 | 0 | 3 |
| SOX12 | APCDD1L | 0.707891 | 3 | 0 | 3 |
| SOX12 | ELMO3 | 0.696728 | 3 | 0 | 3 |
| SOX12 | KATNAL2 | 0.680899 | 3 | 0 | 3 |
| SOX12 | SLC4A11 | 0.67609 | 4 | 0 | 4 |
| SOX12 | CMBL | 0.671881 | 3 | 0 | 3 |
| SOX12 | C19orf44 | 0.669933 | 3 | 0 | 3 |
| SOX12 | RUNX1-IT1 | 0.666703 | 4 | 0 | 3 |
| SOX12 | ADCK5 | 0.664948 | 4 | 0 | 3 |
| SOX12 | SHROOM1 | 0.655774 | 3 | 0 | 3 |
| SOX12 | FBLN7 | 0.655548 | 3 | 0 | 3 |
| SOX12 | OR7A5 | 0.655361 | 3 | 0 | 3 |
| SOX12 | MRGBP | 0.653841 | 9 | 0 | 8 |
| SOX12 | YEATS2 | 0.649475 | 10 | 0 | 10 |
| SOX12 | C20orf141 | 0.64747 | 4 | 0 | 4 |
| SOX12 | IPO9 | 0.646323 | 8 | 0 | 8 |
| SOX12 | RIN1 | 0.64531 | 5 | 0 | 4 |
For details and further investigation, click here
