| Full name: Rho guanine nucleotide exchange factor 10 | Alias Symbol: KIAA0294|Gef10 | ||
| Type: protein-coding gene | Cytoband: 8p23.3 | ||
| Entrez ID: 9639 | HGNC ID: HGNC:14103 | Ensembl Gene: ENSG00000104728 | OMIM ID: 608136 |
| Drug and gene relationship at DGIdb | |||
Expression of ARHGEF10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARHGEF10 | 9639 | 216620_s_at | -0.5783 | 0.3219 | |
| GSE20347 | ARHGEF10 | 9639 | 216620_s_at | 0.6003 | 0.0094 | |
| GSE23400 | ARHGEF10 | 9639 | 216620_s_at | 0.0880 | 0.4106 | |
| GSE26886 | ARHGEF10 | 9639 | 216620_s_at | 1.2712 | 0.0001 | |
| GSE29001 | ARHGEF10 | 9639 | 216620_s_at | 0.5232 | 0.0393 | |
| GSE38129 | ARHGEF10 | 9639 | 216620_s_at | 0.0252 | 0.9428 | |
| GSE45670 | ARHGEF10 | 9639 | 216620_s_at | -0.5123 | 0.1628 | |
| GSE53622 | ARHGEF10 | 9639 | 94892 | 0.0767 | 0.6012 | |
| GSE53624 | ARHGEF10 | 9639 | 94892 | 0.3410 | 0.0023 | |
| GSE63941 | ARHGEF10 | 9639 | 216620_s_at | -0.8451 | 0.3276 | |
| GSE77861 | ARHGEF10 | 9639 | 216620_s_at | 1.0480 | 0.0941 | |
| GSE97050 | ARHGEF10 | 9639 | A_23_P216282 | -0.2822 | 0.4780 | |
| SRP007169 | ARHGEF10 | 9639 | RNAseq | 3.4374 | 0.0000 | |
| SRP008496 | ARHGEF10 | 9639 | RNAseq | 3.1949 | 0.0000 | |
| SRP064894 | ARHGEF10 | 9639 | RNAseq | 0.3602 | 0.1394 | |
| SRP133303 | ARHGEF10 | 9639 | RNAseq | -0.0490 | 0.8922 | |
| SRP159526 | ARHGEF10 | 9639 | RNAseq | 0.4447 | 0.3348 | |
| SRP193095 | ARHGEF10 | 9639 | RNAseq | 1.0454 | 0.0000 | |
| SRP219564 | ARHGEF10 | 9639 | RNAseq | -0.0052 | 0.9909 | |
| TCGA | ARHGEF10 | 9639 | RNAseq | -0.3937 | 0.0008 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by ARHGEF10 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARHGEF10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARHGEF10 | 9639 | 5 | 13 | 12 | |
| GSE20123 | ARHGEF10 | 9639 | 5 | 13 | 12 | |
| GSE43470 | ARHGEF10 | 9639 | 5 | 9 | 29 | |
| GSE46452 | ARHGEF10 | 9639 | 12 | 14 | 33 | |
| GSE47630 | ARHGEF10 | 9639 | 10 | 8 | 22 | |
| GSE54993 | ARHGEF10 | 9639 | 4 | 14 | 52 | |
| GSE54994 | ARHGEF10 | 9639 | 10 | 18 | 25 | |
| GSE60625 | ARHGEF10 | 9639 | 3 | 0 | 8 | |
| GSE74703 | ARHGEF10 | 9639 | 5 | 7 | 24 | |
| GSE74704 | ARHGEF10 | 9639 | 4 | 8 | 8 | |
| TCGA | ARHGEF10 | 9639 | 14 | 41 | 41 |
Total number of gains: 77; Total number of losses: 145; Total Number of normals: 266.
Somatic mutations of ARHGEF10:
Generating mutation plots.
Highly correlated genes for ARHGEF10:
Showing top 20/1069 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARHGEF10 | DOCK11 | 0.782805 | 5 | 0 | 5 |
| ARHGEF10 | MYADM | 0.771225 | 5 | 0 | 5 |
| ARHGEF10 | FNIP2 | 0.761101 | 3 | 0 | 3 |
| ARHGEF10 | C11orf96 | 0.749961 | 4 | 0 | 4 |
| ARHGEF10 | KIAA1324L | 0.747595 | 3 | 0 | 3 |
| ARHGEF10 | SLC6A6 | 0.735215 | 3 | 0 | 3 |
| ARHGEF10 | GAA | 0.73117 | 4 | 0 | 4 |
| ARHGEF10 | ARHGEF25 | 0.720805 | 3 | 0 | 3 |
| ARHGEF10 | SGCE | 0.719817 | 10 | 0 | 10 |
| ARHGEF10 | TRIB1 | 0.718926 | 3 | 0 | 3 |
| ARHGEF10 | MCAM | 0.712229 | 10 | 0 | 9 |
| ARHGEF10 | ANO6 | 0.709732 | 7 | 0 | 6 |
| ARHGEF10 | R3HDM2 | 0.707638 | 3 | 0 | 3 |
| ARHGEF10 | ICAM5 | 0.706311 | 3 | 0 | 3 |
| ARHGEF10 | ZNF703 | 0.699409 | 3 | 0 | 3 |
| ARHGEF10 | RAB23 | 0.698608 | 9 | 0 | 8 |
| ARHGEF10 | PMP22 | 0.697999 | 11 | 0 | 10 |
| ARHGEF10 | USP28 | 0.696971 | 4 | 0 | 3 |
| ARHGEF10 | NPTX1 | 0.696753 | 3 | 0 | 3 |
| ARHGEF10 | RILP | 0.69591 | 3 | 0 | 3 |
For details and further investigation, click here
