| Full name: glucosidase alpha, acid | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q25.3 | ||
| Entrez ID: 2548 | HGNC ID: HGNC:4065 | Ensembl Gene: ENSG00000171298 | OMIM ID: 606800 |
| Drug and gene relationship at DGIdb | |||
Expression of GAA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GAA | 2548 | 202812_at | 0.8939 | 0.1007 | |
| GSE20347 | GAA | 2548 | 202812_at | 0.8018 | 0.0000 | |
| GSE23400 | GAA | 2548 | 202812_at | 0.7570 | 0.0000 | |
| GSE26886 | GAA | 2548 | 202812_at | 0.9027 | 0.0000 | |
| GSE29001 | GAA | 2548 | 202812_at | 0.5691 | 0.0080 | |
| GSE38129 | GAA | 2548 | 202812_at | 0.8603 | 0.0000 | |
| GSE45670 | GAA | 2548 | 202812_at | 0.5437 | 0.0002 | |
| GSE53622 | GAA | 2548 | 47823 | 0.6236 | 0.0000 | |
| GSE53624 | GAA | 2548 | 47823 | 0.9059 | 0.0000 | |
| GSE63941 | GAA | 2548 | 202812_at | -0.3770 | 0.2068 | |
| GSE77861 | GAA | 2548 | 202812_at | 0.4911 | 0.0755 | |
| GSE97050 | GAA | 2548 | A_23_P153026 | 0.2488 | 0.3011 | |
| SRP007169 | GAA | 2548 | RNAseq | 2.2889 | 0.0000 | |
| SRP008496 | GAA | 2548 | RNAseq | 1.8430 | 0.0000 | |
| SRP064894 | GAA | 2548 | RNAseq | 1.6911 | 0.0000 | |
| SRP133303 | GAA | 2548 | RNAseq | 0.9250 | 0.0000 | |
| SRP159526 | GAA | 2548 | RNAseq | 1.5276 | 0.0000 | |
| SRP193095 | GAA | 2548 | RNAseq | 1.3118 | 0.0000 | |
| SRP219564 | GAA | 2548 | RNAseq | 1.0863 | 0.0426 | |
| TCGA | GAA | 2548 | RNAseq | 0.0830 | 0.3405 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by GAA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GAA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GAA | 2548 | 4 | 3 | 23 | |
| GSE20123 | GAA | 2548 | 4 | 3 | 23 | |
| GSE43470 | GAA | 2548 | 2 | 6 | 35 | |
| GSE46452 | GAA | 2548 | 34 | 0 | 25 | |
| GSE47630 | GAA | 2548 | 9 | 1 | 30 | |
| GSE54993 | GAA | 2548 | 2 | 5 | 63 | |
| GSE54994 | GAA | 2548 | 10 | 6 | 37 | |
| GSE60625 | GAA | 2548 | 6 | 0 | 5 | |
| GSE74703 | GAA | 2548 | 2 | 4 | 30 | |
| GSE74704 | GAA | 2548 | 4 | 3 | 13 | |
| TCGA | GAA | 2548 | 29 | 9 | 58 |
Total number of gains: 106; Total number of losses: 40; Total Number of normals: 342.
Somatic mutations of GAA:
Generating mutation plots.
Highly correlated genes for GAA:
Showing top 20/1444 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GAA | C15orf61 | 0.819543 | 3 | 0 | 3 |
| GAA | FLNB | 0.81244 | 3 | 0 | 3 |
| GAA | DHRSX | 0.773061 | 3 | 0 | 3 |
| GAA | ARL2 | 0.761784 | 3 | 0 | 3 |
| GAA | PMS1 | 0.743623 | 3 | 0 | 3 |
| GAA | TRIM35 | 0.742771 | 3 | 0 | 3 |
| GAA | MAN1A1 | 0.738907 | 3 | 0 | 3 |
| GAA | ARHGEF10 | 0.73117 | 4 | 0 | 4 |
| GAA | CHIC1 | 0.725352 | 3 | 0 | 3 |
| GAA | FAM89B | 0.713426 | 4 | 0 | 3 |
| GAA | ZNF319 | 0.708125 | 4 | 0 | 3 |
| GAA | PPP2R2D | 0.706353 | 3 | 0 | 3 |
| GAA | WDR59 | 0.706085 | 3 | 0 | 3 |
| GAA | CERS5 | 0.699919 | 5 | 0 | 4 |
| GAA | ZBTB37 | 0.699516 | 3 | 0 | 3 |
| GAA | DOCK11 | 0.698022 | 4 | 0 | 4 |
| GAA | SH3RF3 | 0.697174 | 3 | 0 | 3 |
| GAA | CCDC127 | 0.696556 | 3 | 0 | 3 |
| GAA | KCNS3 | 0.695218 | 11 | 0 | 11 |
| GAA | NSMCE2 | 0.693362 | 4 | 0 | 3 |
For details and further investigation, click here
