| Full name: ubiquitin specific peptidase 28 | Alias Symbol: KIAA1515 | ||
| Type: protein-coding gene | Cytoband: 11q23.2 | ||
| Entrez ID: 57646 | HGNC ID: HGNC:12625 | Ensembl Gene: ENSG00000048028 | OMIM ID: 610748 |
| Drug and gene relationship at DGIdb | |||
Expression of USP28:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | USP28 | 57646 | 230623_x_at | -0.0107 | 0.9779 | |
| GSE26886 | USP28 | 57646 | 230623_x_at | 1.1437 | 0.0000 | |
| GSE45670 | USP28 | 57646 | 231837_at | 0.2292 | 0.3220 | |
| GSE53622 | USP28 | 57646 | 10084 | 0.4035 | 0.0000 | |
| GSE53624 | USP28 | 57646 | 10084 | 0.3870 | 0.0000 | |
| GSE63941 | USP28 | 57646 | 230623_x_at | 1.1849 | 0.0145 | |
| GSE77861 | USP28 | 57646 | 230623_x_at | 0.4292 | 0.3015 | |
| GSE97050 | USP28 | 57646 | A_33_P3672482 | -0.0306 | 0.9345 | |
| SRP007169 | USP28 | 57646 | RNAseq | 0.8206 | 0.0775 | |
| SRP008496 | USP28 | 57646 | RNAseq | 0.8454 | 0.0006 | |
| SRP064894 | USP28 | 57646 | RNAseq | 0.1467 | 0.4372 | |
| SRP133303 | USP28 | 57646 | RNAseq | 0.3033 | 0.0412 | |
| SRP159526 | USP28 | 57646 | RNAseq | 0.2699 | 0.4356 | |
| SRP193095 | USP28 | 57646 | RNAseq | 0.1871 | 0.0833 | |
| SRP219564 | USP28 | 57646 | RNAseq | -0.0921 | 0.8025 | |
| TCGA | USP28 | 57646 | RNAseq | 0.0035 | 0.9483 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by USP28 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of USP28:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | USP28 | 57646 | 0 | 13 | 17 | |
| GSE20123 | USP28 | 57646 | 0 | 13 | 17 | |
| GSE43470 | USP28 | 57646 | 2 | 7 | 34 | |
| GSE46452 | USP28 | 57646 | 3 | 26 | 30 | |
| GSE47630 | USP28 | 57646 | 2 | 19 | 19 | |
| GSE54993 | USP28 | 57646 | 10 | 0 | 60 | |
| GSE54994 | USP28 | 57646 | 5 | 19 | 29 | |
| GSE60625 | USP28 | 57646 | 0 | 3 | 8 | |
| GSE74703 | USP28 | 57646 | 1 | 5 | 30 | |
| GSE74704 | USP28 | 57646 | 0 | 9 | 11 | |
| TCGA | USP28 | 57646 | 5 | 49 | 42 |
Total number of gains: 28; Total number of losses: 163; Total Number of normals: 297.
Somatic mutations of USP28:
Generating mutation plots.
Highly correlated genes for USP28:
Showing top 20/642 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| USP28 | ZNF251 | 0.811527 | 3 | 0 | 3 |
| USP28 | POMZP3 | 0.782941 | 3 | 0 | 3 |
| USP28 | KRTCAP2 | 0.763034 | 3 | 0 | 3 |
| USP28 | ZNF202 | 0.751 | 3 | 0 | 3 |
| USP28 | SRI | 0.747667 | 3 | 0 | 3 |
| USP28 | NFIB | 0.747134 | 3 | 0 | 3 |
| USP28 | FXR1 | 0.74507 | 3 | 0 | 3 |
| USP28 | TRAP1 | 0.741635 | 3 | 0 | 3 |
| USP28 | NPRL3 | 0.736251 | 3 | 0 | 3 |
| USP28 | PARVB | 0.734678 | 3 | 0 | 3 |
| USP28 | MCMBP | 0.731352 | 3 | 0 | 3 |
| USP28 | DNAJC11 | 0.726175 | 3 | 0 | 3 |
| USP28 | PIK3R3 | 0.725406 | 3 | 0 | 3 |
| USP28 | FAR2 | 0.7244 | 4 | 0 | 4 |
| USP28 | ZXDA | 0.718589 | 4 | 0 | 4 |
| USP28 | ZCCHC8 | 0.717345 | 3 | 0 | 3 |
| USP28 | TRIM47 | 0.717309 | 3 | 0 | 3 |
| USP28 | GLB1L2 | 0.714851 | 3 | 0 | 3 |
| USP28 | PPRC1 | 0.714433 | 3 | 0 | 3 |
| USP28 | ZNF704 | 0.714277 | 4 | 0 | 4 |
For details and further investigation, click here
