| Full name: tribbles pseudokinase 1 | Alias Symbol: C8FW|GIG2|TRB1 | ||
| Type: protein-coding gene | Cytoband: 8q24.13 | ||
| Entrez ID: 10221 | HGNC ID: HGNC:16891 | Ensembl Gene: ENSG00000173334 | OMIM ID: 609461 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TRIB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRIB1 | 10221 | 202241_at | -0.0918 | 0.9345 | |
| GSE20347 | TRIB1 | 10221 | 202241_at | 0.2226 | 0.4129 | |
| GSE23400 | TRIB1 | 10221 | 202241_at | -0.1495 | 0.2635 | |
| GSE26886 | TRIB1 | 10221 | 202241_at | 0.2482 | 0.5011 | |
| GSE29001 | TRIB1 | 10221 | 202241_at | -0.2663 | 0.3974 | |
| GSE38129 | TRIB1 | 10221 | 202241_at | 0.0499 | 0.8649 | |
| GSE45670 | TRIB1 | 10221 | 202241_at | 0.3384 | 0.2940 | |
| GSE53622 | TRIB1 | 10221 | 85237 | -0.1286 | 0.3017 | |
| GSE53624 | TRIB1 | 10221 | 85237 | -0.2950 | 0.0001 | |
| GSE63941 | TRIB1 | 10221 | 202241_at | 0.0878 | 0.9363 | |
| GSE77861 | TRIB1 | 10221 | 202241_at | 0.8650 | 0.0114 | |
| GSE97050 | TRIB1 | 10221 | A_24_P252497 | 0.3780 | 0.4020 | |
| SRP007169 | TRIB1 | 10221 | RNAseq | -1.3231 | 0.0002 | |
| SRP008496 | TRIB1 | 10221 | RNAseq | -1.5628 | 0.0000 | |
| SRP064894 | TRIB1 | 10221 | RNAseq | -0.1580 | 0.5263 | |
| SRP133303 | TRIB1 | 10221 | RNAseq | 0.3105 | 0.2440 | |
| SRP159526 | TRIB1 | 10221 | RNAseq | 0.0029 | 0.9939 | |
| SRP193095 | TRIB1 | 10221 | RNAseq | 0.7623 | 0.0005 | |
| SRP219564 | TRIB1 | 10221 | RNAseq | 0.0263 | 0.9551 | |
| TCGA | TRIB1 | 10221 | RNAseq | -0.2251 | 0.0019 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by TRIB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRIB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRIB1 | 10221 | 18 | 0 | 12 | |
| GSE20123 | TRIB1 | 10221 | 19 | 0 | 11 | |
| GSE43470 | TRIB1 | 10221 | 22 | 0 | 21 | |
| GSE46452 | TRIB1 | 10221 | 28 | 0 | 31 | |
| GSE47630 | TRIB1 | 10221 | 24 | 0 | 16 | |
| GSE54993 | TRIB1 | 10221 | 0 | 21 | 49 | |
| GSE54994 | TRIB1 | 10221 | 37 | 1 | 15 | |
| GSE60625 | TRIB1 | 10221 | 0 | 4 | 7 | |
| GSE74703 | TRIB1 | 10221 | 19 | 0 | 17 | |
| GSE74704 | TRIB1 | 10221 | 13 | 0 | 7 | |
| TCGA | TRIB1 | 10221 | 69 | 1 | 26 |
Total number of gains: 249; Total number of losses: 27; Total Number of normals: 212.
Somatic mutations of TRIB1:
Generating mutation plots.
Highly correlated genes for TRIB1:
Showing top 20/266 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRIB1 | KIF13A | 0.8038 | 3 | 0 | 3 |
| TRIB1 | STX2 | 0.7913 | 3 | 0 | 3 |
| TRIB1 | MACF1 | 0.761588 | 3 | 0 | 3 |
| TRIB1 | PTGFRN | 0.754411 | 3 | 0 | 3 |
| TRIB1 | TEAD4 | 0.752522 | 3 | 0 | 3 |
| TRIB1 | DYNC1LI2 | 0.751765 | 3 | 0 | 3 |
| TRIB1 | MCAM | 0.748927 | 3 | 0 | 3 |
| TRIB1 | TMTC1 | 0.741582 | 3 | 0 | 3 |
| TRIB1 | BCL6 | 0.739148 | 3 | 0 | 3 |
| TRIB1 | ASAP2 | 0.73817 | 3 | 0 | 3 |
| TRIB1 | PUF60 | 0.737486 | 3 | 0 | 3 |
| TRIB1 | ABL2 | 0.736467 | 3 | 0 | 3 |
| TRIB1 | TOR1A | 0.732952 | 3 | 0 | 3 |
| TRIB1 | SLC39A1 | 0.725523 | 3 | 0 | 3 |
| TRIB1 | KIAA0895L | 0.72509 | 3 | 0 | 3 |
| TRIB1 | RHOQ | 0.724774 | 3 | 0 | 3 |
| TRIB1 | TRMT12 | 0.724594 | 3 | 0 | 3 |
| TRIB1 | RASD1 | 0.721092 | 3 | 0 | 3 |
| TRIB1 | GLI2 | 0.719036 | 3 | 0 | 3 |
| TRIB1 | ARHGEF10 | 0.718926 | 3 | 0 | 3 |
For details and further investigation, click here
