| Full name: Rho guanine nucleotide exchange factor 16 | Alias Symbol: NBR|GEF16 | ||
| Type: protein-coding gene | Cytoband: 1p36.32 | ||
| Entrez ID: 27237 | HGNC ID: HGNC:15515 | Ensembl Gene: ENSG00000130762 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of ARHGEF16:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARHGEF16 | 27237 | 208009_s_at | 0.5921 | 0.2400 | |
| GSE20347 | ARHGEF16 | 27237 | 208009_s_at | 0.3752 | 0.0135 | |
| GSE23400 | ARHGEF16 | 27237 | 208009_s_at | 0.0774 | 0.2821 | |
| GSE26886 | ARHGEF16 | 27237 | 208009_s_at | 0.2543 | 0.2775 | |
| GSE29001 | ARHGEF16 | 27237 | 208009_s_at | 0.0705 | 0.8003 | |
| GSE38129 | ARHGEF16 | 27237 | 208009_s_at | 0.3497 | 0.0205 | |
| GSE45670 | ARHGEF16 | 27237 | 208009_s_at | 0.4544 | 0.0011 | |
| GSE53622 | ARHGEF16 | 27237 | 830 | -0.1344 | 0.4734 | |
| GSE53624 | ARHGEF16 | 27237 | 830 | -0.2857 | 0.0022 | |
| GSE63941 | ARHGEF16 | 27237 | 208009_s_at | 1.0979 | 0.0003 | |
| GSE77861 | ARHGEF16 | 27237 | 208009_s_at | 0.1175 | 0.6351 | |
| GSE97050 | ARHGEF16 | 27237 | A_23_P114670 | 0.0759 | 0.7597 | |
| SRP007169 | ARHGEF16 | 27237 | RNAseq | -0.6634 | 0.1903 | |
| SRP008496 | ARHGEF16 | 27237 | RNAseq | -0.7338 | 0.0468 | |
| SRP064894 | ARHGEF16 | 27237 | RNAseq | 0.2271 | 0.5934 | |
| SRP133303 | ARHGEF16 | 27237 | RNAseq | -0.1088 | 0.6973 | |
| SRP159526 | ARHGEF16 | 27237 | RNAseq | 0.0834 | 0.8098 | |
| SRP193095 | ARHGEF16 | 27237 | RNAseq | -0.0555 | 0.7809 | |
| SRP219564 | ARHGEF16 | 27237 | RNAseq | 0.5280 | 0.5474 | |
| TCGA | ARHGEF16 | 27237 | RNAseq | -0.0023 | 0.9860 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ARHGEF16 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARHGEF16:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARHGEF16 | 27237 | 4 | 6 | 20 | |
| GSE20123 | ARHGEF16 | 27237 | 4 | 5 | 21 | |
| GSE43470 | ARHGEF16 | 27237 | 3 | 5 | 35 | |
| GSE46452 | ARHGEF16 | 27237 | 7 | 1 | 51 | |
| GSE47630 | ARHGEF16 | 27237 | 8 | 4 | 28 | |
| GSE54993 | ARHGEF16 | 27237 | 3 | 2 | 65 | |
| GSE54994 | ARHGEF16 | 27237 | 14 | 3 | 36 | |
| GSE60625 | ARHGEF16 | 27237 | 0 | 0 | 11 | |
| GSE74703 | ARHGEF16 | 27237 | 3 | 3 | 30 | |
| GSE74704 | ARHGEF16 | 27237 | 4 | 0 | 16 | |
| TCGA | ARHGEF16 | 27237 | 14 | 20 | 62 |
Total number of gains: 64; Total number of losses: 49; Total Number of normals: 375.
Somatic mutations of ARHGEF16:
Generating mutation plots.
Highly correlated genes for ARHGEF16:
Showing top 20/604 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARHGEF16 | CDCA7 | 0.849245 | 3 | 0 | 3 |
| ARHGEF16 | GGN | 0.782828 | 3 | 0 | 3 |
| ARHGEF16 | CHD7 | 0.765009 | 3 | 0 | 3 |
| ARHGEF16 | SLC25A35 | 0.761835 | 3 | 0 | 3 |
| ARHGEF16 | TRAPPC1 | 0.756658 | 4 | 0 | 4 |
| ARHGEF16 | TMTC4 | 0.750799 | 3 | 0 | 3 |
| ARHGEF16 | GABRR1 | 0.742946 | 3 | 0 | 3 |
| ARHGEF16 | JMJD4 | 0.742789 | 3 | 0 | 3 |
| ARHGEF16 | NENF | 0.737827 | 3 | 0 | 3 |
| ARHGEF16 | ELOVL7 | 0.736662 | 3 | 0 | 3 |
| ARHGEF16 | SCML4 | 0.735846 | 3 | 0 | 3 |
| ARHGEF16 | RNF187 | 0.735062 | 3 | 0 | 3 |
| ARHGEF16 | PARVG | 0.733781 | 3 | 0 | 3 |
| ARHGEF16 | USP21 | 0.733015 | 4 | 0 | 3 |
| ARHGEF16 | PRKCSH | 0.726295 | 4 | 0 | 4 |
| ARHGEF16 | BCL9L | 0.723198 | 4 | 0 | 3 |
| ARHGEF16 | WDR81 | 0.721582 | 3 | 0 | 3 |
| ARHGEF16 | SNAI3 | 0.720994 | 3 | 0 | 3 |
| ARHGEF16 | RIMS2 | 0.716953 | 3 | 0 | 3 |
| ARHGEF16 | NUCB1 | 0.715651 | 5 | 0 | 4 |
For details and further investigation, click here
