| Full name: regulating synaptic membrane exocytosis 2 | Alias Symbol: KIAA0751|RIM2|OBOE | ||
| Type: protein-coding gene | Cytoband: 8q22.3 | ||
| Entrez ID: 9699 | HGNC ID: HGNC:17283 | Ensembl Gene: ENSG00000176406 | OMIM ID: 606630 |
| Drug and gene relationship at DGIdb | |||
RIMS2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04911 | Insulin secretion |
Expression of RIMS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RIMS2 | 9699 | 206137_at | 0.9718 | 0.4278 | |
| GSE20347 | RIMS2 | 9699 | 206137_at | 0.5389 | 0.0001 | |
| GSE23400 | RIMS2 | 9699 | 206137_at | 0.2148 | 0.0006 | |
| GSE26886 | RIMS2 | 9699 | 206137_at | 0.5302 | 0.0035 | |
| GSE29001 | RIMS2 | 9699 | 206137_at | 0.4917 | 0.0535 | |
| GSE38129 | RIMS2 | 9699 | 206137_at | 0.4384 | 0.0092 | |
| GSE45670 | RIMS2 | 9699 | 206137_at | 0.7372 | 0.0154 | |
| GSE53622 | RIMS2 | 9699 | 65094 | 1.5164 | 0.0000 | |
| GSE53624 | RIMS2 | 9699 | 65094 | 0.8067 | 0.0000 | |
| GSE63941 | RIMS2 | 9699 | 206137_at | 1.5547 | 0.0412 | |
| GSE77861 | RIMS2 | 9699 | 206137_at | 0.6178 | 0.0946 | |
| SRP007169 | RIMS2 | 9699 | RNAseq | 0.7334 | 0.3909 | |
| SRP064894 | RIMS2 | 9699 | RNAseq | 3.3746 | 0.0000 | |
| SRP133303 | RIMS2 | 9699 | RNAseq | 2.4343 | 0.0000 | |
| SRP159526 | RIMS2 | 9699 | RNAseq | 2.6706 | 0.0001 | |
| SRP193095 | RIMS2 | 9699 | RNAseq | 2.3601 | 0.0000 | |
| SRP219564 | RIMS2 | 9699 | RNAseq | 2.5378 | 0.0049 | |
| TCGA | RIMS2 | 9699 | RNAseq | 1.1552 | 0.0001 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by RIMS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RIMS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RIMS2 | 9699 | 16 | 0 | 14 | |
| GSE20123 | RIMS2 | 9699 | 17 | 0 | 13 | |
| GSE43470 | RIMS2 | 9699 | 22 | 0 | 21 | |
| GSE46452 | RIMS2 | 9699 | 24 | 0 | 35 | |
| GSE47630 | RIMS2 | 9699 | 24 | 0 | 16 | |
| GSE54993 | RIMS2 | 9699 | 0 | 20 | 50 | |
| GSE54994 | RIMS2 | 9699 | 37 | 1 | 15 | |
| GSE60625 | RIMS2 | 9699 | 0 | 4 | 7 | |
| GSE74703 | RIMS2 | 9699 | 19 | 0 | 17 | |
| GSE74704 | RIMS2 | 9699 | 11 | 0 | 9 | |
| TCGA | RIMS2 | 9699 | 60 | 3 | 33 |
Total number of gains: 230; Total number of losses: 28; Total Number of normals: 230.
Somatic mutations of RIMS2:
Generating mutation plots.
Highly correlated genes for RIMS2:
Showing top 20/304 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RIMS2 | ARHGEF16 | 0.716953 | 3 | 0 | 3 |
| RIMS2 | MAN1B1 | 0.692203 | 4 | 0 | 3 |
| RIMS2 | TRIM47 | 0.673632 | 3 | 0 | 3 |
| RIMS2 | ZNF706 | 0.663847 | 3 | 0 | 3 |
| RIMS2 | RHPN2 | 0.660391 | 3 | 0 | 3 |
| RIMS2 | SP4 | 0.65522 | 3 | 0 | 3 |
| RIMS2 | DGKD | 0.654236 | 5 | 0 | 3 |
| RIMS2 | ZMYND15 | 0.64801 | 4 | 0 | 3 |
| RIMS2 | IGSF8 | 0.641109 | 4 | 0 | 3 |
| RIMS2 | PVR | 0.640417 | 3 | 0 | 3 |
| RIMS2 | LENG8 | 0.634075 | 4 | 0 | 3 |
| RIMS2 | CAPN12 | 0.631824 | 5 | 0 | 4 |
| RIMS2 | FBXO27 | 0.630826 | 4 | 0 | 3 |
| RIMS2 | ADAP1 | 0.630247 | 4 | 0 | 3 |
| RIMS2 | PDE7A | 0.629593 | 4 | 0 | 3 |
| RIMS2 | BSDC1 | 0.627731 | 4 | 0 | 3 |
| RIMS2 | GATAD2B | 0.62563 | 4 | 0 | 3 |
| RIMS2 | IGSF9 | 0.622114 | 4 | 0 | 4 |
| RIMS2 | MARK4 | 0.617144 | 4 | 0 | 3 |
| RIMS2 | KSR2 | 0.615222 | 4 | 0 | 3 |
For details and further investigation, click here
