| Full name: gamma-aminobutyric acid type A receptor rho1 subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6q15 | ||
| Entrez ID: 2569 | HGNC ID: HGNC:4090 | Ensembl Gene: ENSG00000146276 | OMIM ID: 137161 |
| Drug and gene relationship at DGIdb | |||
GABRR1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04727 | GABAergic synapse | |
| hsa05032 | Morphine addiction |
Expression of GABRR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GABRR1 | 2569 | 206525_at | 0.6264 | 0.5087 | |
| GSE20347 | GABRR1 | 2569 | 206525_at | 0.4747 | 0.0000 | |
| GSE23400 | GABRR1 | 2569 | 206525_at | 0.0680 | 0.0710 | |
| GSE26886 | GABRR1 | 2569 | 206525_at | 1.6780 | 0.0006 | |
| GSE29001 | GABRR1 | 2569 | 206525_at | 0.7269 | 0.0007 | |
| GSE38129 | GABRR1 | 2569 | 206525_at | 0.7553 | 0.0000 | |
| GSE45670 | GABRR1 | 2569 | 206525_at | 0.9196 | 0.0172 | |
| GSE53622 | GABRR1 | 2569 | 47686 | 1.3194 | 0.0000 | |
| GSE53624 | GABRR1 | 2569 | 34679 | 1.9251 | 0.0000 | |
| GSE63941 | GABRR1 | 2569 | 206525_at | 0.4830 | 0.4396 | |
| GSE77861 | GABRR1 | 2569 | 206525_at | 0.4425 | 0.0056 | |
| SRP007169 | GABRR1 | 2569 | RNAseq | 5.8133 | 0.0000 | |
| SRP133303 | GABRR1 | 2569 | RNAseq | 1.7206 | 0.0000 | |
| SRP159526 | GABRR1 | 2569 | RNAseq | 2.0628 | 0.0100 | |
| TCGA | GABRR1 | 2569 | RNAseq | 3.4677 | 0.0000 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by GABRR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GABRR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GABRR1 | 2569 | 1 | 4 | 25 | |
| GSE20123 | GABRR1 | 2569 | 1 | 3 | 26 | |
| GSE43470 | GABRR1 | 2569 | 3 | 1 | 39 | |
| GSE46452 | GABRR1 | 2569 | 2 | 11 | 46 | |
| GSE47630 | GABRR1 | 2569 | 8 | 6 | 26 | |
| GSE54993 | GABRR1 | 2569 | 3 | 2 | 65 | |
| GSE54994 | GABRR1 | 2569 | 8 | 8 | 37 | |
| GSE60625 | GABRR1 | 2569 | 0 | 1 | 10 | |
| GSE74703 | GABRR1 | 2569 | 3 | 1 | 32 | |
| GSE74704 | GABRR1 | 2569 | 0 | 2 | 18 | |
| TCGA | GABRR1 | 2569 | 7 | 21 | 68 |
Total number of gains: 36; Total number of losses: 60; Total Number of normals: 392.
Somatic mutations of GABRR1:
Generating mutation plots.
Highly correlated genes for GABRR1:
Showing top 20/561 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GABRR1 | ARHGEF16 | 0.742946 | 3 | 0 | 3 |
| GABRR1 | WDR81 | 0.731313 | 4 | 0 | 4 |
| GABRR1 | PRPSAP2 | 0.704297 | 3 | 0 | 3 |
| GABRR1 | FAXC | 0.702394 | 3 | 0 | 3 |
| GABRR1 | FOXO1 | 0.686769 | 3 | 0 | 3 |
| GABRR1 | UBE2Q1 | 0.669897 | 4 | 0 | 4 |
| GABRR1 | ANKRD23 | 0.665235 | 4 | 0 | 4 |
| GABRR1 | MAGEA11 | 0.664411 | 3 | 0 | 3 |
| GABRR1 | LHX4-AS1 | 0.663132 | 3 | 0 | 3 |
| GABRR1 | TRMT2A | 0.662712 | 3 | 0 | 3 |
| GABRR1 | TCF24 | 0.661808 | 6 | 0 | 6 |
| GABRR1 | ASAP1-IT1 | 0.656726 | 4 | 0 | 4 |
| GABRR1 | DPYSL3 | 0.654874 | 3 | 0 | 3 |
| GABRR1 | PTP4A3 | 0.654287 | 3 | 0 | 3 |
| GABRR1 | CXXC1 | 0.65397 | 3 | 0 | 3 |
| GABRR1 | EVL | 0.650539 | 4 | 0 | 3 |
| GABRR1 | SIPA1L3 | 0.649639 | 5 | 0 | 5 |
| GABRR1 | SETDB1 | 0.647461 | 5 | 0 | 4 |
| GABRR1 | RASEF | 0.646283 | 5 | 0 | 5 |
| GABRR1 | SPSB2 | 0.643291 | 3 | 0 | 3 |
For details and further investigation, click here
