| Full name: ubiquitin specific peptidase 21 | Alias Symbol: USP16 | ||
| Type: protein-coding gene | Cytoband: 1q23.3 | ||
| Entrez ID: 27005 | HGNC ID: HGNC:12620 | Ensembl Gene: ENSG00000143258 | OMIM ID: 604729 |
| Drug and gene relationship at DGIdb | |||
Expression of USP21:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | USP21 | 27005 | 232219_x_at | 0.5789 | 0.1946 | |
| GSE20347 | USP21 | 27005 | 218367_x_at | 0.1304 | 0.3346 | |
| GSE23400 | USP21 | 27005 | 218367_x_at | 0.1741 | 0.0009 | |
| GSE26886 | USP21 | 27005 | 218367_x_at | -0.3358 | 0.2961 | |
| GSE29001 | USP21 | 27005 | 218367_x_at | 0.0259 | 0.9094 | |
| GSE38129 | USP21 | 27005 | 218367_x_at | 0.2408 | 0.0248 | |
| GSE45670 | USP21 | 27005 | 232219_x_at | 0.3203 | 0.0068 | |
| GSE53622 | USP21 | 27005 | 68658 | 0.3163 | 0.0000 | |
| GSE53624 | USP21 | 27005 | 68658 | 0.2574 | 0.0001 | |
| GSE63941 | USP21 | 27005 | 218367_x_at | 1.7931 | 0.0015 | |
| GSE77861 | USP21 | 27005 | 218367_x_at | 0.4520 | 0.0573 | |
| GSE97050 | USP21 | 27005 | A_24_P139620 | 0.0784 | 0.7921 | |
| SRP007169 | USP21 | 27005 | RNAseq | -0.3071 | 0.5012 | |
| SRP008496 | USP21 | 27005 | RNAseq | -0.3351 | 0.2460 | |
| SRP064894 | USP21 | 27005 | RNAseq | 0.0581 | 0.6693 | |
| SRP133303 | USP21 | 27005 | RNAseq | 0.0874 | 0.5914 | |
| SRP159526 | USP21 | 27005 | RNAseq | 0.8996 | 0.0335 | |
| SRP193095 | USP21 | 27005 | RNAseq | 0.1945 | 0.1076 | |
| SRP219564 | USP21 | 27005 | RNAseq | 0.3680 | 0.4220 | |
| TCGA | USP21 | 27005 | RNAseq | 0.0897 | 0.1205 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by USP21 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of USP21:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | USP21 | 27005 | 10 | 0 | 20 | |
| GSE20123 | USP21 | 27005 | 10 | 0 | 20 | |
| GSE43470 | USP21 | 27005 | 7 | 2 | 34 | |
| GSE46452 | USP21 | 27005 | 2 | 1 | 56 | |
| GSE47630 | USP21 | 27005 | 14 | 0 | 26 | |
| GSE54993 | USP21 | 27005 | 0 | 6 | 64 | |
| GSE54994 | USP21 | 27005 | 16 | 0 | 37 | |
| GSE60625 | USP21 | 27005 | 0 | 0 | 11 | |
| GSE74703 | USP21 | 27005 | 7 | 2 | 27 | |
| GSE74704 | USP21 | 27005 | 4 | 0 | 16 | |
| TCGA | USP21 | 27005 | 45 | 3 | 48 |
Total number of gains: 115; Total number of losses: 14; Total Number of normals: 359.
Somatic mutations of USP21:
Generating mutation plots.
Highly correlated genes for USP21:
Showing top 20/876 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| USP21 | ACBD6 | 0.831207 | 3 | 0 | 3 |
| USP21 | PPP1CC | 0.791026 | 3 | 0 | 3 |
| USP21 | C1orf115 | 0.787355 | 3 | 0 | 3 |
| USP21 | ANKRD46 | 0.768866 | 3 | 0 | 3 |
| USP21 | MRPL38 | 0.767546 | 3 | 0 | 3 |
| USP21 | SEMA4A | 0.764301 | 3 | 0 | 3 |
| USP21 | CCDC85C | 0.756581 | 3 | 0 | 3 |
| USP21 | EXD2 | 0.753544 | 3 | 0 | 3 |
| USP21 | SFMBT1 | 0.752146 | 3 | 0 | 3 |
| USP21 | STX16 | 0.742944 | 3 | 0 | 3 |
| USP21 | ADCK1 | 0.741693 | 3 | 0 | 3 |
| USP21 | CRTC2 | 0.741178 | 5 | 0 | 5 |
| USP21 | HOXD8 | 0.74008 | 3 | 0 | 3 |
| USP21 | RPL18 | 0.736315 | 3 | 0 | 3 |
| USP21 | PXN | 0.734898 | 3 | 0 | 3 |
| USP21 | ARHGEF16 | 0.733015 | 4 | 0 | 3 |
| USP21 | MCCC2 | 0.73238 | 3 | 0 | 3 |
| USP21 | DHRSX | 0.727128 | 3 | 0 | 3 |
| USP21 | RNF217 | 0.725761 | 3 | 0 | 3 |
| USP21 | IFNGR1 | 0.724128 | 3 | 0 | 3 |
For details and further investigation, click here
