| Full name: transient receptor potential cation channel subfamily M member 4 | Alias Symbol: FLJ20041 | ||
| Type: protein-coding gene | Cytoband: 19q13.3 | ||
| Entrez ID: 54795 | HGNC ID: HGNC:17993 | Ensembl Gene: ENSG00000130529 | OMIM ID: 606936 |
| Drug and gene relationship at DGIdb | |||
TRPM4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04911 | Insulin secretion |
Expression of TRPM4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRPM4 | 54795 | 219360_s_at | 0.6674 | 0.2888 | |
| GSE20347 | TRPM4 | 54795 | 219360_s_at | 0.1551 | 0.4711 | |
| GSE23400 | TRPM4 | 54795 | 219360_s_at | 0.0223 | 0.7939 | |
| GSE26886 | TRPM4 | 54795 | 219360_s_at | 0.3533 | 0.0696 | |
| GSE29001 | TRPM4 | 54795 | 219360_s_at | 0.1746 | 0.4518 | |
| GSE38129 | TRPM4 | 54795 | 219360_s_at | 0.0813 | 0.6351 | |
| GSE45670 | TRPM4 | 54795 | 219360_s_at | 0.3474 | 0.0441 | |
| GSE53622 | TRPM4 | 54795 | 87463 | 0.0419 | 0.8227 | |
| GSE53624 | TRPM4 | 54795 | 87463 | 0.3085 | 0.0055 | |
| GSE63941 | TRPM4 | 54795 | 219360_s_at | 0.1224 | 0.8177 | |
| GSE77861 | TRPM4 | 54795 | 219360_s_at | 0.4470 | 0.0671 | |
| GSE97050 | TRPM4 | 54795 | A_23_P153529 | -0.0186 | 0.9525 | |
| SRP007169 | TRPM4 | 54795 | RNAseq | 0.6315 | 0.2778 | |
| SRP064894 | TRPM4 | 54795 | RNAseq | 0.4051 | 0.0552 | |
| SRP133303 | TRPM4 | 54795 | RNAseq | 0.0842 | 0.7094 | |
| SRP159526 | TRPM4 | 54795 | RNAseq | -0.0003 | 0.9994 | |
| SRP193095 | TRPM4 | 54795 | RNAseq | 0.0786 | 0.7873 | |
| SRP219564 | TRPM4 | 54795 | RNAseq | 0.2553 | 0.4097 | |
| TCGA | TRPM4 | 54795 | RNAseq | -0.2603 | 0.0013 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TRPM4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRPM4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRPM4 | 54795 | 4 | 4 | 22 | |
| GSE20123 | TRPM4 | 54795 | 4 | 3 | 23 | |
| GSE43470 | TRPM4 | 54795 | 4 | 10 | 29 | |
| GSE46452 | TRPM4 | 54795 | 45 | 1 | 13 | |
| GSE47630 | TRPM4 | 54795 | 10 | 6 | 24 | |
| GSE54993 | TRPM4 | 54795 | 17 | 4 | 49 | |
| GSE54994 | TRPM4 | 54795 | 4 | 14 | 35 | |
| GSE60625 | TRPM4 | 54795 | 9 | 0 | 2 | |
| GSE74703 | TRPM4 | 54795 | 4 | 7 | 25 | |
| GSE74704 | TRPM4 | 54795 | 4 | 1 | 15 | |
| TCGA | TRPM4 | 54795 | 14 | 18 | 64 |
Total number of gains: 119; Total number of losses: 68; Total Number of normals: 301.
Somatic mutations of TRPM4:
Generating mutation plots.
Highly correlated genes for TRPM4:
Showing top 20/473 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRPM4 | C3orf33 | 0.822254 | 3 | 0 | 3 |
| TRPM4 | RAD18 | 0.774346 | 3 | 0 | 3 |
| TRPM4 | C1orf226 | 0.767425 | 3 | 0 | 3 |
| TRPM4 | ARL13B | 0.753708 | 3 | 0 | 3 |
| TRPM4 | U2AF1 | 0.752911 | 3 | 0 | 3 |
| TRPM4 | NASP | 0.752774 | 3 | 0 | 3 |
| TRPM4 | MOB3C | 0.749382 | 3 | 0 | 3 |
| TRPM4 | NPHP1 | 0.744514 | 3 | 0 | 3 |
| TRPM4 | NUDT11 | 0.741217 | 3 | 0 | 3 |
| TRPM4 | IRF2BPL | 0.736763 | 3 | 0 | 3 |
| TRPM4 | ANP32B | 0.729861 | 3 | 0 | 3 |
| TRPM4 | MGAT2 | 0.727777 | 3 | 0 | 3 |
| TRPM4 | CENPBD1 | 0.726483 | 3 | 0 | 3 |
| TRPM4 | ZNF558 | 0.716447 | 4 | 0 | 3 |
| TRPM4 | RAVER1 | 0.714756 | 3 | 0 | 3 |
| TRPM4 | YLPM1 | 0.713445 | 3 | 0 | 3 |
| TRPM4 | EHMT2 | 0.713341 | 3 | 0 | 3 |
| TRPM4 | ABCF2 | 0.709932 | 4 | 0 | 3 |
| TRPM4 | HMGB1 | 0.709105 | 3 | 0 | 3 |
| TRPM4 | HIRA | 0.708638 | 3 | 0 | 3 |
For details and further investigation, click here
