| Full name: histone cell cycle regulator | Alias Symbol: DGCR1|TUP1 | ||
| Type: protein-coding gene | Cytoband: 22q11.21 | ||
| Entrez ID: 7290 | HGNC ID: HGNC:4916 | Ensembl Gene: ENSG00000100084 | OMIM ID: 600237 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of HIRA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HIRA | 7290 | 217427_s_at | 0.3302 | 0.4975 | |
| GSE20347 | HIRA | 7290 | 217427_s_at | -0.2270 | 0.2118 | |
| GSE23400 | HIRA | 7290 | 217427_s_at | 0.3689 | 0.0000 | |
| GSE26886 | HIRA | 7290 | 217427_s_at | 0.1690 | 0.5290 | |
| GSE29001 | HIRA | 7290 | 217427_s_at | 0.5400 | 0.1835 | |
| GSE38129 | HIRA | 7290 | 217427_s_at | 0.1493 | 0.6204 | |
| GSE45670 | HIRA | 7290 | 217427_s_at | 0.2826 | 0.0383 | |
| GSE53622 | HIRA | 7290 | 32872 | 0.1722 | 0.0386 | |
| GSE53624 | HIRA | 7290 | 32872 | 0.7815 | 0.0000 | |
| GSE63941 | HIRA | 7290 | 217427_s_at | 0.6207 | 0.2703 | |
| GSE77861 | HIRA | 7290 | 217427_s_at | 0.8853 | 0.0189 | |
| GSE97050 | HIRA | 7290 | A_23_P154938 | 0.0103 | 0.9709 | |
| SRP007169 | HIRA | 7290 | RNAseq | 1.1255 | 0.0133 | |
| SRP008496 | HIRA | 7290 | RNAseq | 1.1762 | 0.0000 | |
| SRP064894 | HIRA | 7290 | RNAseq | 0.3963 | 0.0218 | |
| SRP133303 | HIRA | 7290 | RNAseq | 0.2053 | 0.0716 | |
| SRP159526 | HIRA | 7290 | RNAseq | 0.2962 | 0.0608 | |
| SRP193095 | HIRA | 7290 | RNAseq | 0.3343 | 0.0044 | |
| SRP219564 | HIRA | 7290 | RNAseq | 0.0790 | 0.7582 | |
| TCGA | HIRA | 7290 | RNAseq | -0.0929 | 0.0562 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by HIRA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HIRA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HIRA | 7290 | 4 | 8 | 18 | |
| GSE20123 | HIRA | 7290 | 4 | 8 | 18 | |
| GSE43470 | HIRA | 7290 | 5 | 6 | 32 | |
| GSE46452 | HIRA | 7290 | 33 | 1 | 25 | |
| GSE47630 | HIRA | 7290 | 8 | 5 | 27 | |
| GSE54993 | HIRA | 7290 | 3 | 7 | 60 | |
| GSE54994 | HIRA | 7290 | 12 | 7 | 34 | |
| GSE60625 | HIRA | 7290 | 5 | 0 | 6 | |
| GSE74703 | HIRA | 7290 | 5 | 4 | 27 | |
| GSE74704 | HIRA | 7290 | 2 | 5 | 13 | |
| TCGA | HIRA | 7290 | 27 | 17 | 52 |
Total number of gains: 108; Total number of losses: 68; Total Number of normals: 312.
Somatic mutations of HIRA:
Generating mutation plots.
Highly correlated genes for HIRA:
Showing top 20/539 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HIRA | CAMKK2 | 0.799957 | 3 | 0 | 3 |
| HIRA | TIGD1 | 0.784965 | 3 | 0 | 3 |
| HIRA | SFSWAP | 0.750356 | 3 | 0 | 3 |
| HIRA | MRPL16 | 0.746244 | 3 | 0 | 3 |
| HIRA | ALS2 | 0.738652 | 3 | 0 | 3 |
| HIRA | HEATR6 | 0.738186 | 3 | 0 | 3 |
| HIRA | ARNT | 0.736993 | 3 | 0 | 3 |
| HIRA | CLCN7 | 0.728943 | 3 | 0 | 3 |
| HIRA | GPATCH2 | 0.722919 | 4 | 0 | 3 |
| HIRA | MED22 | 0.719731 | 3 | 0 | 3 |
| HIRA | VPS37C | 0.717926 | 3 | 0 | 3 |
| HIRA | ZNF280C | 0.71693 | 3 | 0 | 3 |
| HIRA | THEM4 | 0.714708 | 4 | 0 | 3 |
| HIRA | TRPM4 | 0.708638 | 3 | 0 | 3 |
| HIRA | CBFA2T2 | 0.706245 | 3 | 0 | 3 |
| HIRA | NTPCR | 0.706001 | 3 | 0 | 3 |
| HIRA | SMARCA5 | 0.705613 | 3 | 0 | 3 |
| HIRA | RFTN1 | 0.702214 | 3 | 0 | 3 |
| HIRA | LCMT1 | 0.697091 | 3 | 0 | 3 |
| HIRA | FBXL19 | 0.691021 | 3 | 0 | 3 |
For details and further investigation, click here
