| Full name: arrestin beta 2 | Alias Symbol: BARR2|DKFZp686L0365 | ||
| Type: protein-coding gene | Cytoband: 17p13.2 | ||
| Entrez ID: 409 | HGNC ID: HGNC:712 | Ensembl Gene: ENSG00000141480 | OMIM ID: 107941 |
| Drug and gene relationship at DGIdb | |||
ARRB2 involved pathways:
Expression of ARRB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARRB2 | 409 | 203388_at | 0.5669 | 0.1928 | |
| GSE20347 | ARRB2 | 409 | 203388_at | 0.4745 | 0.0000 | |
| GSE23400 | ARRB2 | 409 | 203388_at | 0.2502 | 0.0000 | |
| GSE26886 | ARRB2 | 409 | 203388_at | 0.2284 | 0.0629 | |
| GSE29001 | ARRB2 | 409 | 203388_at | -0.1378 | 0.4584 | |
| GSE38129 | ARRB2 | 409 | 203388_at | 0.3170 | 0.0004 | |
| GSE45670 | ARRB2 | 409 | 203388_at | 0.1190 | 0.3494 | |
| GSE53622 | ARRB2 | 409 | 80698 | -0.3506 | 0.0000 | |
| GSE53624 | ARRB2 | 409 | 80698 | -2.0260 | 0.0000 | |
| GSE63941 | ARRB2 | 409 | 203388_at | 2.5438 | 0.0007 | |
| GSE77861 | ARRB2 | 409 | 203388_at | 0.2588 | 0.1355 | |
| GSE97050 | ARRB2 | 409 | A_23_P158829 | 0.3770 | 0.3304 | |
| SRP007169 | ARRB2 | 409 | RNAseq | 1.7239 | 0.0034 | |
| SRP008496 | ARRB2 | 409 | RNAseq | 1.4337 | 0.0006 | |
| SRP064894 | ARRB2 | 409 | RNAseq | 0.9840 | 0.0000 | |
| SRP133303 | ARRB2 | 409 | RNAseq | 0.5228 | 0.0009 | |
| SRP159526 | ARRB2 | 409 | RNAseq | 0.5415 | 0.0520 | |
| SRP193095 | ARRB2 | 409 | RNAseq | 0.9100 | 0.0000 | |
| SRP219564 | ARRB2 | 409 | RNAseq | 1.0088 | 0.0320 | |
| TCGA | ARRB2 | 409 | RNAseq | -0.0833 | 0.1630 |
Upregulated datasets: 4; Downregulated datasets: 1.
Survival by ARRB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARRB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARRB2 | 409 | 5 | 2 | 23 | |
| GSE20123 | ARRB2 | 409 | 5 | 3 | 22 | |
| GSE43470 | ARRB2 | 409 | 1 | 6 | 36 | |
| GSE46452 | ARRB2 | 409 | 34 | 1 | 24 | |
| GSE47630 | ARRB2 | 409 | 7 | 1 | 32 | |
| GSE54993 | ARRB2 | 409 | 4 | 3 | 63 | |
| GSE54994 | ARRB2 | 409 | 5 | 9 | 39 | |
| GSE60625 | ARRB2 | 409 | 4 | 0 | 7 | |
| GSE74703 | ARRB2 | 409 | 1 | 3 | 32 | |
| GSE74704 | ARRB2 | 409 | 3 | 1 | 16 | |
| TCGA | ARRB2 | 409 | 19 | 21 | 56 |
Total number of gains: 88; Total number of losses: 50; Total Number of normals: 350.
Somatic mutations of ARRB2:
Generating mutation plots.
Highly correlated genes for ARRB2:
Showing top 20/293 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARRB2 | APLNR | 0.731814 | 4 | 0 | 4 |
| ARRB2 | RHOH | 0.702863 | 3 | 0 | 3 |
| ARRB2 | PDE1B | 0.694822 | 4 | 0 | 3 |
| ARRB2 | CXCL16 | 0.693539 | 4 | 0 | 4 |
| ARRB2 | UTS2R | 0.692271 | 3 | 0 | 3 |
| ARRB2 | NTNG1 | 0.68668 | 3 | 0 | 3 |
| ARRB2 | ZC3H12D | 0.666041 | 3 | 0 | 3 |
| ARRB2 | WAS | 0.664599 | 5 | 0 | 5 |
| ARRB2 | TNFAIP1 | 0.664144 | 3 | 0 | 3 |
| ARRB2 | SERPINF1 | 0.663463 | 3 | 0 | 3 |
| ARRB2 | FOXP3 | 0.661845 | 3 | 0 | 3 |
| ARRB2 | FYN | 0.660614 | 3 | 0 | 3 |
| ARRB2 | BCL9L | 0.658363 | 4 | 0 | 4 |
| ARRB2 | ARHGDIA | 0.657954 | 3 | 0 | 3 |
| ARRB2 | CDX1 | 0.657794 | 5 | 0 | 4 |
| ARRB2 | MEFV | 0.657525 | 4 | 0 | 3 |
| ARRB2 | ATOH1 | 0.657014 | 3 | 0 | 3 |
| ARRB2 | CD33 | 0.656804 | 4 | 0 | 4 |
| ARRB2 | C1orf162 | 0.655664 | 3 | 0 | 3 |
| ARRB2 | LPXN | 0.651344 | 4 | 0 | 3 |
For details and further investigation, click here
