| Full name: C-X-C motif chemokine ligand 16 | Alias Symbol: SR-PSOX|CXCLG16|SRPSOX | ||
| Type: protein-coding gene | Cytoband: 17p13.2 | ||
| Entrez ID: 58191 | HGNC ID: HGNC:16642 | Ensembl Gene: ENSG00000161921 | OMIM ID: 605398 |
| Drug and gene relationship at DGIdb | |||
CXCL16 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway |
Expression of CXCL16:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CXCL16 | 58191 | 223454_at | 1.0820 | 0.0384 | |
| GSE26886 | CXCL16 | 58191 | 223454_at | -0.4402 | 0.2139 | |
| GSE45670 | CXCL16 | 58191 | 223454_at | 0.6845 | 0.0001 | |
| GSE53622 | CXCL16 | 58191 | 46892 | 0.6299 | 0.0000 | |
| GSE53624 | CXCL16 | 58191 | 46892 | 0.3303 | 0.0003 | |
| GSE63941 | CXCL16 | 58191 | 223454_at | 2.2528 | 0.0128 | |
| GSE77861 | CXCL16 | 58191 | 223454_at | 0.3884 | 0.2177 | |
| GSE97050 | CXCL16 | 58191 | A_23_P38505 | 0.7645 | 0.1156 | |
| SRP007169 | CXCL16 | 58191 | RNAseq | 0.5210 | 0.3054 | |
| SRP008496 | CXCL16 | 58191 | RNAseq | 0.3641 | 0.2386 | |
| SRP064894 | CXCL16 | 58191 | RNAseq | 0.6429 | 0.0005 | |
| SRP133303 | CXCL16 | 58191 | RNAseq | 0.7027 | 0.0000 | |
| SRP159526 | CXCL16 | 58191 | RNAseq | 0.5917 | 0.2145 | |
| SRP193095 | CXCL16 | 58191 | RNAseq | 0.5646 | 0.0058 | |
| SRP219564 | CXCL16 | 58191 | RNAseq | 0.9464 | 0.0564 | |
| TCGA | CXCL16 | 58191 | RNAseq | 0.1474 | 0.0100 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by CXCL16 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CXCL16:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CXCL16 | 58191 | 5 | 2 | 23 | |
| GSE20123 | CXCL16 | 58191 | 5 | 3 | 22 | |
| GSE43470 | CXCL16 | 58191 | 1 | 6 | 36 | |
| GSE46452 | CXCL16 | 58191 | 34 | 1 | 24 | |
| GSE47630 | CXCL16 | 58191 | 7 | 1 | 32 | |
| GSE54993 | CXCL16 | 58191 | 4 | 3 | 63 | |
| GSE54994 | CXCL16 | 58191 | 5 | 9 | 39 | |
| GSE60625 | CXCL16 | 58191 | 4 | 0 | 7 | |
| GSE74703 | CXCL16 | 58191 | 1 | 3 | 32 | |
| GSE74704 | CXCL16 | 58191 | 3 | 1 | 16 | |
| TCGA | CXCL16 | 58191 | 19 | 21 | 56 |
Total number of gains: 88; Total number of losses: 50; Total Number of normals: 350.
Somatic mutations of CXCL16:
Generating mutation plots.
Highly correlated genes for CXCL16:
Showing top 20/920 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CXCL16 | TMTC4 | 0.814806 | 3 | 0 | 3 |
| CXCL16 | YWHAE | 0.808457 | 3 | 0 | 3 |
| CXCL16 | CISD2 | 0.794065 | 3 | 0 | 3 |
| CXCL16 | MVP | 0.784826 | 3 | 0 | 3 |
| CXCL16 | XRN1 | 0.781016 | 3 | 0 | 3 |
| CXCL16 | WDR81 | 0.779338 | 3 | 0 | 3 |
| CXCL16 | DERL1 | 0.776221 | 3 | 0 | 3 |
| CXCL16 | PAICS | 0.771603 | 3 | 0 | 3 |
| CXCL16 | TNFAIP1 | 0.770019 | 4 | 0 | 4 |
| CXCL16 | ADAM15 | 0.763909 | 3 | 0 | 3 |
| CXCL16 | LGALS8 | 0.762566 | 3 | 0 | 3 |
| CXCL16 | CCT6A | 0.759854 | 3 | 0 | 3 |
| CXCL16 | CMTM4 | 0.75978 | 3 | 0 | 3 |
| CXCL16 | PRKCD | 0.759328 | 3 | 0 | 3 |
| CXCL16 | G3BP1 | 0.751239 | 3 | 0 | 3 |
| CXCL16 | NEK6 | 0.746424 | 3 | 0 | 3 |
| CXCL16 | POLR2K | 0.744852 | 3 | 0 | 3 |
| CXCL16 | SLC39A3 | 0.741392 | 3 | 0 | 3 |
| CXCL16 | SLC25A44 | 0.73992 | 4 | 0 | 4 |
| CXCL16 | TFAP2A | 0.738673 | 4 | 0 | 4 |
For details and further investigation, click here
