FYN

 

Full name: FYN proto-oncogene, Src family tyrosine kinase Alias Symbol: SYN|SLK|MGC45350
Type: protein-coding gene Cytoband: 6q21
Entrez ID: 2534 HGNC ID: HGNC:4037 Ensembl Gene: ENSG00000010810 OMIM ID: 137025
Drug and gene relationship at DGIdb

 

FYN involved pathways:

KEGG pathway Description View
hsa04071Sphingolipid signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04360Axon guidance
hsa04380Osteoclast differentiation
hsa04510Focal adhesion
hsa04520Adherens junction
hsa04611Platelet activation
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04725Cholinergic synapse
hsa05020Prion diseases
hsa05162Measles

 

Expression of FYN:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FYN 2534 210105_s_at -0.0256 0.9812
GSE20347 FYN 2534 210105_s_at 0.4157 0.0585
GSE23400 FYN 2534 210105_s_at 0.2683 0.0491
GSE26886 FYN 2534 210105_s_at 1.4876 0.0017
GSE29001 FYN 2534 210105_s_at 0.4940 0.2130
GSE38129 FYN 2534 210105_s_at 0.0219 0.9397
GSE45670 FYN 2534 210105_s_at -0.8235 0.0352
GSE53622 FYN 2534 4974 0.3387 0.0049
GSE53624 FYN 2534 4974 0.2798 0.0173
GSE63941 FYN 2534 210105_s_at -2.0108 0.1454
GSE77861 FYN 2534 210105_s_at 1.1439 0.0060
GSE97050 FYN 2534 A_23_P502142 0.4404 0.1466
SRP007169 FYN 2534 RNAseq 1.5438 0.0131
SRP008496 FYN 2534 RNAseq 1.3403 0.0051
SRP064894 FYN 2534 RNAseq 0.4195 0.0832
SRP133303 FYN 2534 RNAseq 0.1452 0.4570
SRP159526 FYN 2534 RNAseq -0.0461 0.8773
SRP193095 FYN 2534 RNAseq 0.8365 0.0006
SRP219564 FYN 2534 RNAseq 0.2995 0.3379
TCGA FYN 2534 RNAseq -0.2017 0.0178

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by FYN expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FYN:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FYN 2534 2 4 24
GSE20123 FYN 2534 2 3 25
GSE43470 FYN 2534 3 1 39
GSE46452 FYN 2534 2 11 46
GSE47630 FYN 2534 9 4 27
GSE54993 FYN 2534 3 2 65
GSE54994 FYN 2534 8 8 37
GSE60625 FYN 2534 0 2 9
GSE74703 FYN 2534 2 1 33
GSE74704 FYN 2534 0 1 19
TCGA FYN 2534 6 23 67

Total number of gains: 37; Total number of losses: 60; Total Number of normals: 391.  

 

Somatic mutations of FYN:

 

Generating mutation plots.

 

Highly correlated genes for FYN:

 

Showing top 20/1145 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FYNSSRP10.823053303
FYNDNAH140.795064303
FYNDGUOK0.793311303
FYNBRAT10.792987303
FYNRTKN0.792048303
FYNMSTO10.790417303
FYNZNF4960.774068303
FYNSSBP40.768493404
FYNALKBH60.760278303
FYNSTK30.757861303
FYNPFDN20.755241303
FYNPET1170.752525303
FYNXPR10.752379303
FYNCERKL0.746629303
FYNNXT10.74372303
FYNPSMD30.740981303
FYNNUF20.738786303
FYNLRRC590.737496303
FYNTRMT60.737494303
FYNSYTL20.732048505

For details and further investigation, click here