| Full name: apelin receptor | Alias Symbol: FLJ90771|APJ|APJR | ||
| Type: protein-coding gene | Cytoband: 11q12.1 | ||
| Entrez ID: 187 | HGNC ID: HGNC:339 | Ensembl Gene: ENSG00000134817 | OMIM ID: 600052 |
| Drug and gene relationship at DGIdb | |||
Expression of APLNR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APLNR | 187 | 213592_at | 0.7942 | 0.2781 | |
| GSE20347 | APLNR | 187 | 213592_at | 0.2398 | 0.0416 | |
| GSE23400 | APLNR | 187 | 213592_at | 0.1456 | 0.0041 | |
| GSE26886 | APLNR | 187 | 213592_at | 0.1911 | 0.3295 | |
| GSE29001 | APLNR | 187 | 213592_at | 0.3337 | 0.3649 | |
| GSE38129 | APLNR | 187 | 213592_at | 0.1537 | 0.5518 | |
| GSE45670 | APLNR | 187 | 213592_at | 0.2527 | 0.6124 | |
| GSE53622 | APLNR | 187 | 85740 | 0.3144 | 0.0316 | |
| GSE53624 | APLNR | 187 | 48001 | 0.1565 | 0.3739 | |
| GSE63941 | APLNR | 187 | 213592_at | 0.0262 | 0.8667 | |
| GSE77861 | APLNR | 187 | 213592_at | 0.3520 | 0.0707 | |
| GSE97050 | APLNR | 187 | A_23_P318860 | 1.1335 | 0.1221 | |
| SRP007169 | APLNR | 187 | RNAseq | 1.9801 | 0.0061 | |
| SRP064894 | APLNR | 187 | RNAseq | 2.8462 | 0.0000 | |
| SRP133303 | APLNR | 187 | RNAseq | 0.0709 | 0.8328 | |
| SRP159526 | APLNR | 187 | RNAseq | 0.9903 | 0.0606 | |
| SRP219564 | APLNR | 187 | RNAseq | 1.3418 | 0.1357 | |
| TCGA | APLNR | 187 | RNAseq | 0.0279 | 0.8652 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by APLNR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APLNR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APLNR | 187 | 2 | 3 | 25 | |
| GSE20123 | APLNR | 187 | 2 | 3 | 25 | |
| GSE43470 | APLNR | 187 | 1 | 5 | 37 | |
| GSE46452 | APLNR | 187 | 9 | 4 | 46 | |
| GSE47630 | APLNR | 187 | 3 | 9 | 28 | |
| GSE54993 | APLNR | 187 | 3 | 0 | 67 | |
| GSE54994 | APLNR | 187 | 5 | 6 | 42 | |
| GSE60625 | APLNR | 187 | 0 | 3 | 8 | |
| GSE74703 | APLNR | 187 | 1 | 3 | 32 | |
| GSE74704 | APLNR | 187 | 2 | 3 | 15 | |
| TCGA | APLNR | 187 | 14 | 10 | 72 |
Total number of gains: 42; Total number of losses: 49; Total Number of normals: 397.
Somatic mutations of APLNR:
Generating mutation plots.
Highly correlated genes for APLNR:
Showing top 20/622 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APLNR | PPP1R18 | 0.741988 | 3 | 0 | 3 |
| APLNR | SENP3 | 0.741459 | 3 | 0 | 3 |
| APLNR | ARRB2 | 0.731814 | 4 | 0 | 4 |
| APLNR | GANAB | 0.711756 | 3 | 0 | 3 |
| APLNR | PHLDB2 | 0.699156 | 4 | 0 | 4 |
| APLNR | TIE1 | 0.692527 | 9 | 0 | 7 |
| APLNR | RBM14 | 0.684584 | 4 | 0 | 4 |
| APLNR | RRBP1 | 0.683826 | 3 | 0 | 3 |
| APLNR | POLA2 | 0.681537 | 3 | 0 | 3 |
| APLNR | PPP1R35 | 0.680153 | 3 | 0 | 3 |
| APLNR | ENG | 0.675277 | 12 | 0 | 10 |
| APLNR | TAGLN2 | 0.667647 | 4 | 0 | 3 |
| APLNR | UBFD1 | 0.666676 | 4 | 0 | 3 |
| APLNR | UBE2E3 | 0.664178 | 3 | 0 | 3 |
| APLNR | SLC39A1 | 0.662554 | 4 | 0 | 3 |
| APLNR | PDCD1LG2 | 0.662116 | 4 | 0 | 3 |
| APLNR | SLC30A7 | 0.662077 | 3 | 0 | 3 |
| APLNR | XPR1 | 0.660687 | 4 | 0 | 3 |
| APLNR | CIC | 0.658954 | 3 | 0 | 3 |
| APLNR | TRRAP | 0.658885 | 3 | 0 | 3 |
For details and further investigation, click here
