| Full name: Rho GDP dissociation inhibitor alpha | Alias Symbol: RHOGDI | ||
| Type: protein-coding gene | Cytoband: 17q25.3 | ||
| Entrez ID: 396 | HGNC ID: HGNC:678 | Ensembl Gene: ENSG00000141522 | OMIM ID: 601925 |
| Drug and gene relationship at DGIdb | |||
ARHGDIA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04722 | Neurotrophin signaling pathway | |
| hsa04962 | Vasopressin-regulated water reabsorption |
Expression of ARHGDIA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARHGDIA | 396 | 211716_x_at | 0.3844 | 0.3303 | |
| GSE20347 | ARHGDIA | 396 | 211716_x_at | -0.2552 | 0.0446 | |
| GSE23400 | ARHGDIA | 396 | 211716_x_at | 0.0234 | 0.7568 | |
| GSE26886 | ARHGDIA | 396 | 211716_x_at | 0.0609 | 0.8263 | |
| GSE29001 | ARHGDIA | 396 | 201168_x_at | -0.2127 | 0.4702 | |
| GSE38129 | ARHGDIA | 396 | 211716_x_at | -0.1361 | 0.1797 | |
| GSE45670 | ARHGDIA | 396 | 201168_x_at | 0.2036 | 0.0110 | |
| GSE53622 | ARHGDIA | 396 | 28646 | -0.1405 | 0.0433 | |
| GSE53624 | ARHGDIA | 396 | 28646 | 0.0609 | 0.4437 | |
| GSE63941 | ARHGDIA | 396 | 211716_x_at | 0.5298 | 0.1286 | |
| GSE77861 | ARHGDIA | 396 | 211716_x_at | 0.0795 | 0.8262 | |
| GSE97050 | ARHGDIA | 396 | A_23_P207766 | 0.7963 | 0.0631 | |
| SRP007169 | ARHGDIA | 396 | RNAseq | -0.4716 | 0.2430 | |
| SRP008496 | ARHGDIA | 396 | RNAseq | -0.5912 | 0.0500 | |
| SRP064894 | ARHGDIA | 396 | RNAseq | 0.2628 | 0.2753 | |
| SRP133303 | ARHGDIA | 396 | RNAseq | 0.1237 | 0.4889 | |
| SRP159526 | ARHGDIA | 396 | RNAseq | -0.0406 | 0.8907 | |
| SRP193095 | ARHGDIA | 396 | RNAseq | -0.1278 | 0.3842 | |
| SRP219564 | ARHGDIA | 396 | RNAseq | 0.1316 | 0.7135 | |
| TCGA | ARHGDIA | 396 | RNAseq | 0.0508 | 0.2358 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ARHGDIA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARHGDIA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARHGDIA | 396 | 4 | 4 | 22 | |
| GSE20123 | ARHGDIA | 396 | 4 | 4 | 22 | |
| GSE43470 | ARHGDIA | 396 | 3 | 5 | 35 | |
| GSE46452 | ARHGDIA | 396 | 34 | 0 | 25 | |
| GSE47630 | ARHGDIA | 396 | 9 | 2 | 29 | |
| GSE54993 | ARHGDIA | 396 | 2 | 5 | 63 | |
| GSE54994 | ARHGDIA | 396 | 10 | 6 | 37 | |
| GSE60625 | ARHGDIA | 396 | 6 | 0 | 5 | |
| GSE74703 | ARHGDIA | 396 | 3 | 3 | 30 | |
| GSE74704 | ARHGDIA | 396 | 4 | 3 | 13 | |
| TCGA | ARHGDIA | 396 | 25 | 12 | 59 |
Total number of gains: 104; Total number of losses: 44; Total Number of normals: 340.
Somatic mutations of ARHGDIA:
Generating mutation plots.
Highly correlated genes for ARHGDIA:
Showing top 20/447 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARHGDIA | SEC61A1 | 0.765575 | 3 | 0 | 3 |
| ARHGDIA | LIPE | 0.752097 | 3 | 0 | 3 |
| ARHGDIA | SLC12A9 | 0.742268 | 4 | 0 | 4 |
| ARHGDIA | LDLRAP1 | 0.726093 | 3 | 0 | 3 |
| ARHGDIA | LSM4 | 0.716062 | 3 | 0 | 3 |
| ARHGDIA | HGS | 0.69652 | 10 | 0 | 9 |
| ARHGDIA | NOVA2 | 0.688083 | 4 | 0 | 4 |
| ARHGDIA | DEPDC5 | 0.683612 | 3 | 0 | 3 |
| ARHGDIA | EHMT2 | 0.683567 | 3 | 0 | 3 |
| ARHGDIA | MKI67 | 0.681961 | 3 | 0 | 3 |
| ARHGDIA | CALR | 0.679232 | 5 | 0 | 4 |
| ARHGDIA | GLIS3 | 0.67899 | 3 | 0 | 3 |
| ARHGDIA | ARHGEF11 | 0.672582 | 4 | 0 | 4 |
| ARHGDIA | MLLT1 | 0.67189 | 3 | 0 | 3 |
| ARHGDIA | AGMAT | 0.671018 | 3 | 0 | 3 |
| ARHGDIA | RAB11B | 0.669024 | 5 | 0 | 4 |
| ARHGDIA | ACOT7 | 0.662289 | 3 | 0 | 3 |
| ARHGDIA | ARRB2 | 0.657954 | 3 | 0 | 3 |
| ARHGDIA | ZNF385A | 0.655017 | 5 | 0 | 3 |
| ARHGDIA | SLC25A35 | 0.654301 | 3 | 0 | 3 |
For details and further investigation, click here
