| Full name: anti-silencing function 1A histone chaperone | Alias Symbol: DKFZP547E2110|CIA | ||
| Type: protein-coding gene | Cytoband: 6q22.31 | ||
| Entrez ID: 25842 | HGNC ID: HGNC:20995 | Ensembl Gene: ENSG00000111875 | OMIM ID: 609189 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of ASF1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ASF1A | 25842 | 203428_s_at | 0.4107 | 0.2400 | |
| GSE20347 | ASF1A | 25842 | 203427_at | 0.1606 | 0.4614 | |
| GSE23400 | ASF1A | 25842 | 203427_at | 0.4560 | 0.0001 | |
| GSE26886 | ASF1A | 25842 | 203427_at | -0.1134 | 0.7276 | |
| GSE29001 | ASF1A | 25842 | 203428_s_at | 0.6548 | 0.1120 | |
| GSE38129 | ASF1A | 25842 | 203427_at | 0.0907 | 0.6052 | |
| GSE45670 | ASF1A | 25842 | 203427_at | -0.0195 | 0.9405 | |
| GSE63941 | ASF1A | 25842 | 203428_s_at | 0.8739 | 0.1190 | |
| GSE77861 | ASF1A | 25842 | 203427_at | 0.2109 | 0.6659 | |
| GSE97050 | ASF1A | 25842 | A_24_P112087 | -0.2665 | 0.4102 | |
| SRP007169 | ASF1A | 25842 | RNAseq | 0.7834 | 0.1003 | |
| SRP008496 | ASF1A | 25842 | RNAseq | 0.8435 | 0.0090 | |
| SRP064894 | ASF1A | 25842 | RNAseq | -0.0173 | 0.9300 | |
| SRP133303 | ASF1A | 25842 | RNAseq | 0.1112 | 0.5159 | |
| SRP159526 | ASF1A | 25842 | RNAseq | 0.6963 | 0.0028 | |
| SRP193095 | ASF1A | 25842 | RNAseq | 0.0898 | 0.5372 | |
| SRP219564 | ASF1A | 25842 | RNAseq | -0.1491 | 0.6525 | |
| TCGA | ASF1A | 25842 | RNAseq | 0.0598 | 0.3755 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ASF1A expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ASF1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ASF1A | 25842 | 1 | 4 | 25 | |
| GSE20123 | ASF1A | 25842 | 1 | 3 | 26 | |
| GSE43470 | ASF1A | 25842 | 4 | 1 | 38 | |
| GSE46452 | ASF1A | 25842 | 2 | 11 | 46 | |
| GSE47630 | ASF1A | 25842 | 9 | 4 | 27 | |
| GSE54993 | ASF1A | 25842 | 3 | 2 | 65 | |
| GSE54994 | ASF1A | 25842 | 8 | 8 | 37 | |
| GSE60625 | ASF1A | 25842 | 0 | 1 | 10 | |
| GSE74703 | ASF1A | 25842 | 3 | 1 | 32 | |
| GSE74704 | ASF1A | 25842 | 0 | 1 | 19 | |
| TCGA | ASF1A | 25842 | 10 | 20 | 66 |
Total number of gains: 41; Total number of losses: 56; Total Number of normals: 391.
Somatic mutations of ASF1A:
Generating mutation plots.
Highly correlated genes for ASF1A:
Showing top 20/393 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ASF1A | QSER1 | 0.777437 | 3 | 0 | 3 |
| ASF1A | MPP6 | 0.776393 | 3 | 0 | 3 |
| ASF1A | CYBA | 0.75299 | 3 | 0 | 3 |
| ASF1A | FIBP | 0.748165 | 3 | 0 | 3 |
| ASF1A | TACO1 | 0.747683 | 3 | 0 | 3 |
| ASF1A | SCAMP3 | 0.743871 | 3 | 0 | 3 |
| ASF1A | CFDP1 | 0.728052 | 4 | 0 | 4 |
| ASF1A | FAM98A | 0.724541 | 3 | 0 | 3 |
| ASF1A | POLB | 0.720099 | 3 | 0 | 3 |
| ASF1A | GLA | 0.716521 | 4 | 0 | 3 |
| ASF1A | KDM5B | 0.716427 | 3 | 0 | 3 |
| ASF1A | CDCA3 | 0.71407 | 3 | 0 | 3 |
| ASF1A | ZNF627 | 0.712393 | 3 | 0 | 3 |
| ASF1A | MOGS | 0.711818 | 3 | 0 | 3 |
| ASF1A | MKNK1 | 0.704748 | 3 | 0 | 3 |
| ASF1A | PHIP | 0.703537 | 3 | 0 | 3 |
| ASF1A | XPNPEP3 | 0.70104 | 3 | 0 | 3 |
| ASF1A | KATNA1 | 0.700426 | 4 | 0 | 3 |
| ASF1A | NDUFV1 | 0.698562 | 3 | 0 | 3 |
| ASF1A | KCNE3 | 0.69729 | 3 | 0 | 3 |
For details and further investigation, click here
