| Full name: MAPK interacting serine/threonine kinase 1 | Alias Symbol: MNK1 | ||
| Type: protein-coding gene | Cytoband: 1p33 | ||
| Entrez ID: 8569 | HGNC ID: HGNC:7110 | Ensembl Gene: ENSG00000079277 | OMIM ID: 606724 |
| Drug and gene relationship at DGIdb | |||
MKNK1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04066 | HIF-1 signaling pathway | |
| hsa04910 | Insulin signaling pathway |
Expression of MKNK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MKNK1 | 8569 | 209467_s_at | 0.2218 | 0.5155 | |
| GSE20347 | MKNK1 | 8569 | 209467_s_at | 0.1610 | 0.1669 | |
| GSE23400 | MKNK1 | 8569 | 209467_s_at | 0.1808 | 0.0006 | |
| GSE26886 | MKNK1 | 8569 | 209467_s_at | -0.0582 | 0.8086 | |
| GSE29001 | MKNK1 | 8569 | 209467_s_at | 0.0382 | 0.9029 | |
| GSE38129 | MKNK1 | 8569 | 209467_s_at | 0.1485 | 0.1367 | |
| GSE45670 | MKNK1 | 8569 | 209467_s_at | 0.1542 | 0.2548 | |
| GSE53622 | MKNK1 | 8569 | 29048 | 0.2869 | 0.0007 | |
| GSE53624 | MKNK1 | 8569 | 105651 | 0.3298 | 0.0000 | |
| GSE63941 | MKNK1 | 8569 | 209467_s_at | 0.2243 | 0.5937 | |
| GSE77861 | MKNK1 | 8569 | 209467_s_at | 0.5413 | 0.1344 | |
| GSE97050 | MKNK1 | 8569 | A_23_P200126 | 0.0754 | 0.7247 | |
| SRP007169 | MKNK1 | 8569 | RNAseq | 0.0886 | 0.8353 | |
| SRP008496 | MKNK1 | 8569 | RNAseq | 0.1195 | 0.6596 | |
| SRP064894 | MKNK1 | 8569 | RNAseq | 0.2622 | 0.0049 | |
| SRP133303 | MKNK1 | 8569 | RNAseq | 0.1672 | 0.1905 | |
| SRP159526 | MKNK1 | 8569 | RNAseq | 0.3532 | 0.3827 | |
| SRP193095 | MKNK1 | 8569 | RNAseq | 0.4642 | 0.0006 | |
| SRP219564 | MKNK1 | 8569 | RNAseq | 0.0370 | 0.9021 | |
| TCGA | MKNK1 | 8569 | RNAseq | -0.0540 | 0.2839 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MKNK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MKNK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MKNK1 | 8569 | 4 | 3 | 23 | |
| GSE20123 | MKNK1 | 8569 | 4 | 2 | 24 | |
| GSE43470 | MKNK1 | 8569 | 5 | 1 | 37 | |
| GSE46452 | MKNK1 | 8569 | 2 | 1 | 56 | |
| GSE47630 | MKNK1 | 8569 | 8 | 4 | 28 | |
| GSE54993 | MKNK1 | 8569 | 0 | 1 | 69 | |
| GSE54994 | MKNK1 | 8569 | 11 | 2 | 40 | |
| GSE60625 | MKNK1 | 8569 | 0 | 0 | 11 | |
| GSE74703 | MKNK1 | 8569 | 4 | 1 | 31 | |
| GSE74704 | MKNK1 | 8569 | 2 | 0 | 18 | |
| TCGA | MKNK1 | 8569 | 10 | 17 | 69 |
Total number of gains: 50; Total number of losses: 32; Total Number of normals: 406.
Somatic mutations of MKNK1:
Generating mutation plots.
Highly correlated genes for MKNK1:
Showing top 20/390 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MKNK1 | LIPG | 0.777401 | 3 | 0 | 3 |
| MKNK1 | MAP4K4 | 0.776405 | 3 | 0 | 3 |
| MKNK1 | FAM192A | 0.775382 | 3 | 0 | 3 |
| MKNK1 | BABAM1 | 0.774984 | 3 | 0 | 3 |
| MKNK1 | FBXO39 | 0.765977 | 3 | 0 | 3 |
| MKNK1 | PPP1R35 | 0.765602 | 3 | 0 | 3 |
| MKNK1 | DYNLRB1 | 0.737055 | 3 | 0 | 3 |
| MKNK1 | PLXNB2 | 0.728188 | 3 | 0 | 3 |
| MKNK1 | IAH1 | 0.723595 | 3 | 0 | 3 |
| MKNK1 | SPPL2A | 0.71357 | 3 | 0 | 3 |
| MKNK1 | CBX1 | 0.712637 | 3 | 0 | 3 |
| MKNK1 | NOC2L | 0.712307 | 3 | 0 | 3 |
| MKNK1 | UBE2Q2 | 0.709795 | 3 | 0 | 3 |
| MKNK1 | CENPH | 0.707482 | 3 | 0 | 3 |
| MKNK1 | EIF4A3 | 0.706606 | 4 | 0 | 4 |
| MKNK1 | MPG | 0.706417 | 4 | 0 | 3 |
| MKNK1 | COPA | 0.705053 | 4 | 0 | 3 |
| MKNK1 | ASF1A | 0.704748 | 3 | 0 | 3 |
| MKNK1 | CD109 | 0.696731 | 3 | 0 | 3 |
| MKNK1 | FIBP | 0.694185 | 3 | 0 | 3 |
For details and further investigation, click here
